ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶£¨Í¨Ñ¶Ô±¶¡ÌΣ©ÈËÌå¾úȺÓë¶àÖÖ¼²²¡Ç×½üÏà¹Ø£¬£¬£¬¾«×¼µ÷¿Ø¾úȺÒѾ³ÉΪ΢ÉúÎï×éѧµÄÈÈÃÅ¿ÆÑ§ÎÊÌ⡣Ȼ¶ø£¬£¬£¬ÈËÌå¾úȺ¶àÑùÐԸߡ¢ÈËȺÒìÖÊÐÔ´ó¡¢×é³ÉºÍ¹¦Ð§µÄ¶¯Ì¬Öش󣬣¬£¬ÊµÏÖ¾úȺ¾«×¼µ÷¿ØÌôÕ½ÖØ´ó£»ÕâÆäÖÐÆÊÎö΢ÉúÎïȺÂä×é×°»úÖÆÖÁ¹ØÖ÷Òª¡£Ï¸¾úȺÌå¸ÐÓ¦(Bacterial quorum sensing, QS)×÷Ϊϸ¾ú½»Á÷ÐÅÏ¢ºÍÏ໥×÷ÓõÄÖ÷Òª»úÖÆ£¬£¬£¬¾ßÓÐÆÕ±éÐÔ¡¢ÌØÒìÐԺ͵÷¿ØÄÜÁ¦£»µ«Ï¸¾úQSÊÇ·ñÔõÑùµ÷¿ØÈËÀà΢ÉúÎïȺÂäµÄ×é×°Àú³ÌÉв»ÇåÎú¡£
Õë¶ÔÕâÒ»Ö÷ÒªÎÊÌ⣬£¬£¬ngµç×ÓÓÎÏ·ÖÐɽҽѧԺ¶¡ÌοÎÌâ×éÓÚ2023Äê11ÔÂ6ÈÕ ÔÚMicrobiomeÔÓÖ¾ÉÏÔÚÏß½ÒÏþÁËÌâΪ¡°Bacterial quorum sensing orchestrates longitudinal interactions to shape microbiota assembly¡±µÄÑо¿ÂÛÎÄ¡£¸ÃÑо¿ÖÐʹÓÃÔÚÌåÍâ´î½¨µÄÓÅ»¯µÄ¿ÚÇ»ÉúÎﱻĤ£¨oral biofilm microbiota£¬£¬£¬OBM£©µÄ×éװƽ̨£¬£¬£¬ÕæÊµÄ£Äâ²¢×·×ÙÁË¿ÚÇ»ÉúÎﱻĤ¾úȺOBMµÄ×é×°È«Àú³Ì¡£Á¬ÏµÌåÍâÄ£×Ó×÷Óý£¬£¬£¬ºê»ùÒò×é²âÐò£¬£¬£¬¸ßͨÁ¿Êý¾ÝÆÊÎöÒÔ¼°ÐźÅ×ÌÈÅʵÑ飬£¬£¬¸ÃÑо¿·¢Ã÷OBMµÄ×é×°Àú³ÌÖУ¬£¬£¬ÒÀ´Î´¦ÓÚÓÅÊÆÖ°Î»µÄ½¹µã¾úStreptococcus, Veillonella-Megasphaera groupºÍPrevotella-Fusobacteria group£¬£¬£¬Í¨¹ýʱÐòÐÔµÄQSÍøÂç¾ÙÐÐÐÅÏ¢½»Á÷ʵÏÖ¾úÖּ以×÷£¬£¬£¬Íƶ¯¾úȺ½á¹¹µÄÐò¹áÑÝÌæ¡£
×÷ÕßʹÓûìÏýÍÙÒº¡¢ÓÅ»¯µÄ×÷Óý»ùºÍÑáÑõÊÂÇéվģÄâÈËÌå¿ÚÇ»ö¸ÏÂÕæÕæÏàÐΣ¬£¬£¬ÔÚÌåÍâ´î½¨ÉèÁËÓÅ»¯µÄÌåÍâ¿ÚÇ»ÉúÎïĤ΢ÉúÎïȺ×é×°(OBMA)Ä£×Ó£¬£¬£¬»¹ÔÁËOBMµÄÌØÕ÷×é×°Àú³Ì£¬£¬£¬»ñµÃÁËOBMʱÐò×é×°Àú³ÌÖеĺê»ùÒò×é¡£

ͼһ£º£º£º×ÔÖ÷Éè¼Æ´î½¨µÄ¿ÚÇ»¾úȺ×é×°ÌåÍâÄ£×ÓOBMA
×÷Õß¹¹½¨ÁËϸ¾úȺÌå¸ÐÓ¦£¨QS£©Í¨Â·ÖÐÐźźϳɺÍÐźŸÐÓ¦ÂѰ×ÐòÁвο¼¿â£¬£¬£¬²¢½«ÆäÓëʱÐòOBMºê»ùÒò×é¾ÙÐÐͬԴ±È¶Ô£¬£¬£¬´ÓÖз¢Ã÷ÁË2291¸öQSͬԴÂѰף¬£¬£¬Éæ¼°21ÌõQSͨ·£»ÕâЩQSͨ·´ó¶àÔÚOBMÖÐÊÇÊ״η¢Ã÷£¬£¬£¬²¢ÔÚOBM×é×°Àú³ÌÖгÊÏÖʱÐò¸»¼¯Ìص㡣¾ÓɶԻñµÃµÄQSͬԴÂѰ׾ÙÐÐÎïÖÖ¹éÀàÆÊÎö£¬£¬£¬×÷Õß·¢Ã÷OBMÖеÄQSͨ·Ö÷ҪȪԴ×Ô¾úȺ×é×°Àú³ÌÖÐʱÐò¸»¼¯µÄÓÅÊÆÎïÖÖ£¬£¬£¬°üÀ¨Á´Çò¾ú¡¢Î¤ÈÙÊÏÇò¾ú-¾ÞÇòÐ;ú¡¢ÆÕÀ×ÎÖ¾ú-Ëó¸Ë¾ú£¬£¬£¬ÕâЩ¾ú×÷Ϊ½¹µãÊàŦ¹¹½¨ÁËOBM×齨Àú³ÌÖеĽ¹µãQS×ÝÏòÍ¨Ñ¶ÍøÂ磻½øÒ»²½Á¬ÏµÉÏÊö½¹µãÎïÖֵĸ»¼¯Ê±¼ä¡¢QSÐźźϳɺ͸ÐÓ¦ÂѰ×Öֱ𼰸»¼¯Ê±¼ä£¬£¬£¬×÷Õß·¢Ã÷QSÐźÅÔÚ¾úÈºÍ¨Ñ¶ÍøÂçÖÐÊÇË«Ïòת´ïµÄ£¬£¬£¬²¢¶Ô¾úȺ×é×°Àú³ÌÖеÄȺÂä½á¹¹¶¨Ïòת»»¾ßÓÐÒªº¦×÷Óá£

¿ÚÇ»¾úȺ×é×°Àú³ÌÖн¹µã¾úÖÖͨ¹ýQSÐźŷÖ×Ó¾ÙÐÐË«Ïòµ÷¿Ø
ΪÁËÑéÖ¤×ÝÏòQSÍøÂçÔÚ×°ÅäÀú³ÌÖе͍ÏòËÜÔìÄÜÁ¦£¬£¬£¬×÷ÕßʹÓÃQS×ÌÈÅʵÑé¶Ô¾úȺÖеÄAI-2Í¨Ñ¶ÍøÂç¾ÙÐÐÁË×è¶Ï¸ÉÔ¤£¬£¬£¬·¢Ã÷×ÌÈÅ´ãÃð¾úȺÄÚµÄAI-2ÐźÅÍøÂçºó£¬£¬£¬OBMµÄ×é×°·ºÆðÁËÑÓ³Ù²¢ÇÒ×é×°³ÉÊìµÄ±»Ä¤¸üΪųÈõ£»ÆäÖÐÔçÆÚ¶¨Ö²µÄ½¹µã¾úÁ´Çò¾úµÄÔöÖ³ÑÓÉ죬£¬£¬¶øÍíÆÚ¶¨Ö²µÄ½¹µã¾úÆÕÀ×ÎÖ¾úºÍËó¸Ë¾úµÄÔöÖ³Ôò±»ÒÖÖÆ¡£
¸ÃÑо¿Õ¹ÏÖÁËÈËÀà¿ÚÇ»ÉúÎﱻĤ¾úȺÀú³ÌÖеÄ×ÝÏòʱÐòȺÌå¸ÐÓ¦£¨QS£©ÍøÂ磬£¬£¬²¢Í¨¹ýʵÑéÑéÖ¤ÁËQSÍøÂçÔÚÔ¤²âºÍʹÓþúȺװÅäÀú³ÌÖеÄÓÐÓÃÐÔ¡£¸ÃÊÂÇéΪչÏÖ×ÔÈ»ÖØ´ó΢ÉúÎïȺȺ¼¯µÄDZÔÚ»úÖÆÌṩÁËеÄÊӽǣ¬£¬£¬²¢ÎªÍ¨¹ý¸ÉÔ¤QSÍøÂç×îÖÕ׼ȷʹÓÃÈËÀà¾úȺÌṩÁËÖ÷ÒªµÄÀíÂÛ»ù´¡¡£
ngµç×ÓÓÎÏ·ÖÐɽҽѧԺ¶¡ÌοÎÌâ×鲩ʿºóËÕӱΪÂÛÎĵĵÚÒ»×÷Õß¡£¶¡ÌνÌÊÚΪÂÛÎĵÄͨѶ×÷Õß¡£¸ÃÏîÄ¿Êܵ½Á˹ú¼Ò×ÔÈ»¿ÆÑ§»ù½ð¡¢Öйú²©Ê¿ºó¿ÆÑ§»ù½ðºÍ¹ã¶«Ê¡»ù´¡ºÍÓ¦Óûù´¡Ñо¿»ù½ðµÄ×ÊÖú¡£
ÉÔÔçǰ£¬£¬£¬¶¡ÌνÌÊÚÍŶӻ¹ÔÚGut MicrobesÔÓÖ¾½ÒÏþ×ÛÊö¡°Targeting microbial quorum sensing: the next frontier to hinder bacterial driven gastrointestinal infections¡±£¨µÚÒ»×÷ÕßΪËÕÓ±²©Ê¿ºó£©£¬£¬£¬ÖÜÈ«×ÛÊöÁËQS»úÖÆÔÚ²¡Ô¾úÇý¶¯Î¸³¦µÀѬȾµÄ½ÇÉ«ºÍ×÷Ó㬣¬£¬Ã¶¾ÙÁËÔÚ賦µÀ¾úȺÖз¢Ã÷µÄQSÐźÅÒÔ¼°ËüÃǼÓÈëµ÷¿Ø¾úȺÐÄÀí´úл¹¦Ð§µÄʵÀý¡£
¸ÃÂÛÎÄÌÖÂÛÁ˲¡Ô¾úÔõÑùͨ¹ýQSÆÆËð賦µÀ΢ÉúÎïȺÂ䯽ºâ£¬£¬£¬¾úȺÔõÑùͨ¹ýQS»úÖÆ´Ì¼¤ËÞÖ÷Òý·¢Ñ×Ö¢¼°Ö×Áö×ªÒÆÒÔ¼°ËÞÖ÷¶ÔÖ²¡¾úȺQSͨѶµÄ»ØÊÖÕ½ÂÔ¡£¸Ã×ÛÊöÌÖÂÛÁË»ùÓÚ¾úȺQSÑз¢ÐÂÐ;úȺÁÆ·¨µÄؽ´ý½â¾öµÄÌôÕ½£¬£¬£¬²¢Õ¹ÍûÁËÕâÏîÊÂÇéµÄÖØ´óÔ¶¾°ºÍ¼ÛÖµ¡£
ÂÛÎÄÁ´½Ó£º£º£º
https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-023-01699-4
https://pubmed.ncbi.nlm.nih.gov/37680117/