ngµç×ÓÓÎÏ·ÐÂÎÅÍøѶ£¨Í¨Ñ¶Ô±¼òÎÄÑî¡¢´÷Ï£°²£©ÔÚÖÚ¶àµÄ¹¦Ð§¾úȺÖУ¬¹ãΪÈËÖªµÄÊdz¦µÀÒæÉú¾ú£¬¿ÉÊÇÔÚ³¦µÀ΢Éú̬ÀïÍ·£¬³ýÁËϸ¾úÖ®Í⣬ÉÐÓдó×ڵIJ¡¶¾ºÍÕæ¾ú£¬ÔÚijЩ³Ì¶ÈÉÏ£¬ËüÃÇÔÚ·à±ã΢ÉúÎïÒÆÖ²£¨FMT£©ÖÎÁƳ¦µÀ΢Éú̬ÔÓÂÒµÄЧ¹ûÖУ¬Í¬ÑùÊÎÑÝÁËÖÁ¹ØÖ÷ÒªµÄ½ÇÉ«¡£¡£¡£

¿ËÈÕ£¬ngµç×ÓÓÎÏ·Á¥ÊôµÚÁùÒ½ÔºÊܹú¼ÊÖøÃûÆÚ¿¯The Lancet×Ó¿¯The Lancet Gastroenterology & Hepatology Ñû¸å£¬ÒÔҽԺΪµÚÒ»µ¥Î»ÔÚÏß½ÒÏþÌâΪ¡°Roles of the gut virome and mycobiome in faecal microbiota transplantation¡±µÄ×ÛÊö£¬ÏêϸÐðÊöÁ˳¦µÀ²¡¶¾ºÍÕæ¾úÔÚ·à±ã΢ÉúÎïÒÆÖ²£¨FMT£©ÖÎÁƲî±ð¼²²¡ÖеÄ×÷Óᣡ£¡£ngµç×ÓÓÎÏ·Á¥ÊôµÚÁùÒ½Ôº×óÌÎÑо¿Ô±¡¢À¼Æ½½ÌÊÚºÍÎâС½£Ö÷ÈÎҽʦΪÅäºÏͨѶ×÷Õߣ¬Ï¤Äá´óѧSiu Lam¡¢ngµç×ÓÓÎÏ·Á¥ÊôµÚÁùÒ½Ôº°×СÎ䲩ʿ¡¢°®¶ûÀ¼¹úÁ¢¿Æ¿Ë´óѧAndrey ShkoporovºÍ¸çÂ×±ÈÑÇ´óѧHeekuk ParkΪÅäÏàÖúÕß¡£¡£¡£

×óÌνéÉܵ½£¬ÈËÌå¶àÖÖ¼²²¡Èç¼èÄÑËó¾úѬȾ¡¢·ÊÅÖÖ¢¡¢2 ÐÍÌÇÄò²¡¡¢»µËÀÐÔС³¦½á³¦Ñס¢Ñ×Ö¢ÐÔ³¦²¡µÈ£¬×ÅʵÓ볦µÀ΢Éú̬ÔÓÂÒÇ×½üÏà¹Ø¡£¡£¡£Ç°ÎÄËùÌáµ½µÄFMT¾ÍÊÇÒ»ÖÖͨ¹ýÒÆÖ²¿µ½¡¹©ÌåµÄ·à±ã΢ÉúÎïÖƱ¸ÒºÖÁ»¼Õß³¦µÀÖУ¬ÒÔµÖ´ïÖØÖû¼Õß³¦µÀ΢Éú̬¡¢ÖÎÁƼ²²¡µÄÄ¿µÄ¡£¡£¡£³¦µÀ΢Éú̬ÖУ¬³ýÁËϸ¾úÖ®Í⣬»¹º¬Óдó×ڵIJ¡¶¾ºÍÕæ¾ú£¬Ò²»®·Ö±»Í³³ÆΪ³¦µÀ²¡¶¾ÈººÍÕæ¾úȺ¡£¡£¡£²¡¶¾×éºÍÕæ¾ú×é¶Ô FMT ÖÎÁÆÀֳɵÄÓ°ÏìÖ±µ½×î½ü²Å»ñµÃÖØÊÓ¡£¡£¡£

½üÄêÀ´µÄÑо¿·¢Ã÷£¬³¦µÀ²¡¶¾ÈººÍÕæ¾úȺÔÚÈËÌ念½¡ºÍ¼²²¡µÄ±¬·¢¿ªÕ¹ÖÐÊÎÑÝÁËÖ÷Òª½ÇÉ«£¬ÓÈÆäÊÇÔÚFMT΢ÉúÎïÒÆÖ²¶¨Ö²ºÍÁÆЧÖÐÆä×÷ÓÃÈÕÒæÏÔ×Å¡£¡£¡£¸Ã×ÛÊöÏêϸÐðÊöÁ˳¦µÀ²¡¶¾ÈººÍÕæ¾úȺÔÚFMTÖÎÁƲî±ð¼²²¡ÖÐÊÎÑݵIJî±ð½ÇÉ«¡£¡£¡£Í¬Ê±£¬ÎÄÕÂÒ²ÐðÊöÁ˲¡¶¾ÈººÍÕæ¾úȺµÄÒÆÖ²¶ÔËÞÖ÷´øÀ´Àû±×²î±ðµÄÓ°Ïì¡£¡£¡£ÆäÖУ¬ÊɾúÌ壨ϸ¾ú²¡¶¾£©µÄÒÆÖ²ºÍÄîÖé¾ú£¨Õæ¾ú£©µÄÒÆÖ²ÔÚFMTÖÎÁÆÖÐÊÎÑÝÁËÓÈÆäÖ÷ÒªµÄ½ÇÉ«¡£¡£¡£

ͼ1£º£º³¦µÀ²¡¶¾ÈºµÄ×é³ÉºÍ¹¦Ð§ (A)ÈËÀ೦µÀ²¡¶¾ÈºµÄ×é³ÉºÍÓ°ÏìÒò×Ó (B)³¦µÀ²¡¶¾ÈºÔÚËÞÖ÷ÖеĹ¦Ð§

¾Ý½éÉÜ£¬ÈËÀ೦µÀ²¡¶¾×éÖ÷Òª°üÀ¨Ô­ºË²¡¶¾£¨Ö÷ÒªÊÇÊɾúÌ壩ºÍÕæºË²¡¶¾¡£¡£¡£ÆäÖУ¬ÊɾúÌåÔÚ賦µÀ¾ßÓÐÓÐÎÂ˳ÐͺÍÁѽâÐͽ»ÌæµÄÉúÃüÖÜÆÚ£¬¿ÉÒÔͨ¹ýÕûºÏºÍÁѽâµÄ·½Ê½Ó°Ï쳦µÀϸ¾úµÄ×é³É¡£¡£¡£¿µ½¡µÄÈËÀ೦µÀ²¡¶¾×éÓÉÎÂ˳ÐÍÊɾúÌå¿ØÖÆ£¬ÔÚËÞÖ÷Ñ×֢ʱ´úÆä¿ÉÒÔ´ÓÎÂ˳Ð͸´ÖÆת±äΪÁѽâÐ͸´ÖÆ¡£¡£¡£ÓÉÓÚ³¦µÀ²¡¶¾×éÖÐÊɾúÌå¶ÔÕæºË²¡¶¾Õ¼ÓÐÓÅÊƼ°ÆäÔÚµ÷Àíϸ¾ú×é×é³ÉÖеÄÖ±½Ó×÷Óú͹¦Ð§£¬ÊɾúÌåÒ»Ö±ÊÇ´ó´ó¶¼ÈËÀ೦µÀ²¡¶¾×éÑо¿¹Ø×¢µÄ½¹µã¡£¡£¡£FMTµÄ²¡¶¾ÒÔ¼°Ï¸¾úÒÆÖ²Òѱ»Ö¤ÊµÓë¶àÖÖ¼²²¡µÄÁÆЧÏà¹Ø£¬°üÀ¨¼èÄÑËó¾úѬȾ¡¢Ñ×Ö¢ÐÔ³¦²¡ºÍÔìѪ¸Éϸ°ûÒÆÖ²ºóÒÆÖ²ÎËÞÖ÷²¡¡£¡£¡£2019 ÄêÒÔÀ´£¬ÒѾ­ÓÐһЩʹÓÃÎÞ¾ú·à±ãÂËÒººÍ·à±ã²¡¶¾ÒÆÖ²µÄÑо¿À´ÐðÊö³¦µÀ²¡¶¾×éÔÚ¼²²¡ÖÎÁÆÖеÄ×÷Ó㬰üÀ¨·ÊÅÖÖ¢¡¢2 ÐÍÌÇÄò²¡¡¢»µËÀÐÔС³¦½á³¦Ñ׺Ϳ¹ÉúËغó΢ÉúÎïȺʧµ÷µÈ¡£¡£¡£

ͼ2 ³¦µÀÕæ¾úȺµÄ×é³ÉºÍ¹¦Ð§ (A)ÈËÀ೦µÀÕæ¾úȺµÄ×é³ÉºÍÓ°ÏìÒò×Ó (B)³¦µÀÕæ¾úȺÔÚËÞÖ÷ÖеĹ¦Ð§

ÁíÒ»·½Ã棬ÈËÌå賦µÀº¬Óи»ºñµÄÕæ¾ú£¬Í³³ÆΪ³¦µÀÕæ¾úȺ¡£¡£¡£º£ºê»ùÒò×é²âÐòÏÔʾÕæ¾úÔ¼Õ¼³¦µÀ΢ÉúÎïȺµÄ 0.1%¡£¡£¡£Ñо¿Åú×¢£¬³¦µÀº¬ÓÐÁè¼Ý 50ÖÖÕæ¾úÊô£¬ÆäÖÐÄîÖé¾úÊô¡¢½Íĸ¾úÊô¡¢Ö¦æß¾úÊôºÍÂíÀ­É«¾úÊô×ºñ¡£¡£¡£³¦µÀ³£×¤Õæ¾úÓ볦µÀϸ¾ú¾ßÓй²ÉúºÍÞ׿¹ÐÔ£¬ÅäºÏÀ´ËÜÔìËÞÖ÷ÃâÒßÁ¦¡£¡£¡£³¦µÀÕæ¾úÒѾ­±»Ö¤ÊµÓë΢ÉúÎï×é×°ºÍÃâÒß·¢ÓýÓÐÒò¹û¹Øϵ¡£¡£¡£Ô½À´Ô½¶àµÄÖ¤¾ÝÅú×¢³¦µÀÕæ¾úȺ¿ÉÒÔÇ¿ÁÒµØÓ°ÏìËÞÖ÷ÃâÒßϵͳ£¬ÕâÖÖÏ໥×÷ÓÃÓëϸ¾ú»îÐÔÏà¹Ø¡£¡£¡£³¦µÀÕæ¾úȺʧµ÷ÔÚÖÖÖÖ¼²²¡µÄ·¢²¡»úÖÆÖÐÆðÖ÷ÒªµÄ×÷Óᣡ£¡£ÕâÅú×¢°ÐÏò³¦µÀÕæ¾úȺÊÇÒ»ÖÖºÜÓÐÔ¶¾°µÄÖÎÁÆÒªÁì¡£¡£¡£

×óÌÎÌåÏÖ£¬FMTÖÎÁƼ²²¡µÄÖ÷Òª¹¦Ð§ÊÇÒÀÀµÖØ´óµÄÈËÌåϸ¾úȺ-²¡¶¾Èº-Õæ¾úȺ-ËÞÖ÷ÃâÒß»¥×÷À´ÊµÏÖ¡£¡£¡£ÔÚδÀ´µÄ»ù´¡Ñо¿ºÍת»¯Ñо¿ÖУ¬½«»á½øÒ»²½Õ¹ÏÖÕæ¾úºÍ²¡¶¾ÔÚ¼²²¡ÖÎÁÆÖеÄ×÷Ó㬲¢ÓÉ´ËÖ¸µ¼½øÒ»²½µÄÁÙ´²×ª»¯¡£¡£¡£

ÂÛÎÄÁ´½Ó£º£ºhttps://www.thelancet.com/journals/langas/article/PIIS2468-1253(21)00303-4/fulltext