ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶£¨Í¨Ñ¶Ô±¸ß•F£©¸ßѪѹÊÇÎÒ¹ú×î³£¼ûµÄÂýÐÔ²¡£¬£¬£¬¸ßѪѹѪ¹ÜÖØ¹¹ÊÇÓÕµ¼ÄÔ×äÖеȲ¢·¢Ö¢Ö÷ÒªÓ°ÏìÒòËØ¡£¡£¡£ÑªÇåµÍÂÈÇéÐÎÓëÐÄѪ¹Ü¼²²¡Ô¤ºó¾ßÓÐÇ×½üÏà¹ØÐÔ£¬£¬£¬¿ÉÒÔ×÷ΪԤ²âÐÄѪ¹Ü¼²²¡²¡ËÀÂʵÄÌØÊâµÄ×ÔÁ¦Ô¤²âÒòËØ¡£¡£¡£µ«ÑªÇåµÍÂÈÇéÐÎÓë¸ßѪѹÄÔѪ¹ÜÖØ¹¹Ö®¼ä¹ØÏµ¼°»úÖÆÉв»Ã÷È·¡£¡£¡£
¿ËÈÕ£¬£¬£¬ngµç×ÓÓÎÏ·ÖÐɽҽѧԺ¹ØÓÀÔ´¡¢Íõ¹ÚÀÙ½ÌÊÚÍŶӹØÓÚ¸ßѪѹÄÔѪ¹ÜÖØ¹¹µÄÑо¿È¡µÃÐÂÏ£Íû£¬£¬£¬Ñо¿Ð§¹ûÓÚ2022Äê2ÔÂ11ÈÕÒÔÑо¿³¤ÎÄ£¨Article£©ÐÎʽ½ÒÏþÓÚÐÄѪ¹ÜÁìÓòȨÍþÆÚ¿¯Hypertension£¬£¬£¬ÌâΪ¡°Low Chloride¨CRegulated ClC-5 Contributes to Arterial Smooth Muscle Cell Proliferation and Cerebrovascular Remodeling¡±£¬£¬£¬Õ¹ÏÖÁËѪ¹Üƽ»¬¼¡Ï¸°ûCl-ͨµÀ/תÔËÌåClC-5ÊÇÅþÁ¬µÍÂÈÇéÐÎÓëÄÔѪ¹ÜÖØ¹¹²¡Àíת±äµÄÊàŦ£¬£¬£¬ClC-5ͨ¹ý¸ÐÊܵÍÂȴ̼¤¡¢½éµ¼Cl-ÍâÁ÷£¬£¬£¬´Ó¶øÔö½øÄÔѪ¹ÜÖØ¹¹µÄ±¬·¢¡£¡£¡£
ÔÚÕâÏîÑо¿ÊÂÇéÖУ¬£¬£¬Ñо¿ÍŶÓÊ×ÏÈ·¢Ã÷µÍÂȴ̼¤¿ÉÓÕ·¢ÍâÏòÇ¿ÕûÁ÷ÐÔCl-µçÁ÷£¬£¬£¬ÆäµçÁ÷ÌØÕ÷ÓëClC-5½éµ¼µÄµçÁ÷ÌØÕ÷ÀàËÆ¡£¡£¡£Ñо¿Õ߼̶øÔÚ¸ßѪѹ¶¯ÎïÄÔ»ùµ×¶¯ÂöÖз¢Ã÷ClC-5µÄ±í´ï¼°Í¨µÀ»îÐÔ¾ùÓëѪѹÔö¸ß³ÉÕýÏà¹ØÐÔ¡£¡£¡£ClC-5»ùÒòÇóýµÄ¸ßѪѹСÊóÌåÏÖΪÄÔѪ¹ÜÖØ¹¹³Ì¶ÈÏÔ׿õÇᣬ£¬£¬´ËÀú³ÌÓëÓ°ÏìѪ¹Üƽ»¬¼¡Ï¸°ûÔöÖ³Ïà¹Ø¡£¡£¡£»£»úÖÆÉÏ£¬£¬£¬µÍÂÈÇéÐÎÔö½øÁËѪ¹Üƽ»¬¼¡Ï¸°ûClC-5¿ª·Å¼°°ûÄÚCl-ÍâÁ÷Àú³Ì£¬£¬£¬Ëæ×ŰûÄÚCl-Ũ¶È½µµÍ£¬£¬£¬Cl-ÃôллøWNK1¼¤»î²¢ÓÕµ¼AKTÁ×Ëữ£¬£¬£¬×îÖÕÓÕµ¼Ï¸°ûÖÜÆÚÐźÅתµ¼¼°Ï¸°ûÔöÖ³¡£¡£¡£
±¾Ñо¿Ê×´Î֤ʵClC-5ÊǵÍÂÈÇéÐÎ×÷ÓÃÓÚÐÄѪ¹Ü¼²²¡²¡ÀíÀú³ÌµÄÖ÷Òª°Ðµã·Ö×Ó£¬£¬£¬ÅúעѪ¹Üƽ»¬¼¡ClC-5ÊÇ·ÀÖθßѪѹѪ¹ÜÖØ¹¹µÄае㡣¡£¡£ÏÖÔÚ¿¹¸ßѪѹҩÎï½öÄܲ¿·Ö½µµÍÄÔ×äÖз¢²¡ÂÊ£¬£¬£¬µ«²»¿ÉÍêÈ«Äæ×ªÄÔѪ¹ÜÖØ¹¹µÄ±¬·¢£¬£¬£¬±¾Ñо¿Ð§¹ûÏÔʾClC-5С·Ö×ÓÒÖÖÆ¼Á»òµ¥¿Ë¡¿¹ÌåµÄÑз¢¿ÉÄܳÉΪ·ÀÖθßѪѹÄÔѪ¹ÜÖØ¹¹µÄÐÂÕ½ÂÔ¡£¡£¡£

µÍÂÈÇéÐÎͨ¹ý¼¤»îClC-5¼°ÏÂÓÎWNK1/AKTͨ·Ôö½øÄÔѪ¹Üƽ»¬¼¡Ï¸°ûÔöÖ³¼°ÄÔѪ¹ÜÖØ¹¹
ngµç×ÓÓÎÏ·ÖÐɽҽѧԺ¹ØÓÀÔ´½ÌÊÚ¡¢Íõ¹ÚÀÙ½ÌÊں͹㶫ʡÈËÃñÒ½ÔºÐÄѪ¹Ü²¡Ñо¿ËùÕűó½ÌÊÚΪ¸ÃÂÛÎĵÄͨѶ×÷Õߣ¬£¬£¬ngµç×ÓÓÎÏ·Á¥ÊôµÚÁùÒ½Ôº¸ß•F¸±Ö÷ÈÎҩʦ¡¢ngµç×ÓÓÎÏ·ÖÐɽҽѧԺÂíÏÔן±½ÌÊÚ¡¢ngµç×ÓÓÎÏ·ÖÐɽҽѧԺ˶ʿÑо¿Éú¬·ïæÃΪ¸ÃÂÛÎĵĵÚÒ»×÷Õß¡£¡£¡£¸ÃÊÂÇé»ñµÃÁ˹ú¼Ò×ÔÈ»¿ÆÑ§»ù½ðÖØµãÏîÄ¿¡¢ÃæÉÏÏîÄ¿µÄÖ§³Ö¡£¡£¡£
ÂÛÎÄÁ´½Ó£ºhttps://www.ahajournals.org/doi/abs/10.1161/HYPERTENSIONAHA.121.18472