ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶£¨¿µ¾þÃù£©Á¥ÊôµÚÒ»Ò½ÔºÂÀÍò¸ï½ÌÊÚÍŶÓÁªºÏÕÅåó½ÌÊÚÍŶÓϵͳÐÔ»æÖƽºÖÊÁö¹¦Ð§ÐÔÔöÇ¿×Ó»¥×÷ͼÆ×£¬£¬ÆÊÎö·çÏÕSNPÇý¶¯µÄ´ÙÖ×Áö»úÖÆ£¬£¬Ïà¹ØÑо¿Ð§¹û½ÒÏþÓÚ¡¶Nature Cell Biology¡·£¨×ÔÈ»-ϸ°ûÉúÎïѧ£©¡£
Éñ¾½ºÖÊÁö£¨Glioma£©ÊÇÇÖÏ®ÐÔÇ¿µÄÖÐÊàÉñ¾ÏµÍ³Ö×Áö£¬£¬ÎåÄêÉúÑÄÂÊȱ·¦10%¡£Ö»¹ÜÈ«»ùÒò×鹨ÁªÑо¿£¨GWAS£©ÒÑ·¢Ã÷¶à¸öÓë·çÏÕÏà¹ØµÄ·Ç±àÂëÇøÓòµÄµ¥ºËÜÕËá¶à̬ÐÔ£¨SNP£©£¬£¬ÆäÖ²¡»úÀíÈÔ²»ÇåÎú¡£
¸ÃÑо¿Í¨¹ýÁ¬Ïµ¸ßͨÁ¿CRISPRiÓëH3K27ac HiChIPÊÖÒÕ£¬£¬ÏµÍ³»æÖƽºÖÊÁöÔöÇ¿×Ó»¥×÷ÍøÂ磬£¬¾«×¼Åä¶Ô´ÙÖ×ÁöÔöÇ¿×ÓÓëÔ¶¶Ë°Ð»ùÒò¡£ÍŶӷ¢Ã÷´ó¶¼Òѱ¨µÀ·çÏÕSNPλÓÚÔöÇ¿×Ó¡£ÒÔrs2297440ΪÀý£¬£¬¸ÃλµãËùÔÚÔöÇ¿×ÓËäλÓÚRTEL1ÄÚº¬×ÓÇøÓò£¬£¬È´Í¨¹ýÈýάȾɫÖÊÓëSOX18Ï໥×÷ÓÃÇý¶¯Æä±í´ï£»£»ÇóýÔöÇ¿×Ó»ò½«·çÏÕµÈλ»ùÒòµ¥¼î»ù±à¼Îª·Ç·çÏÕÐÎʽ£¬£¬¾ù½µµÍÔöÇ¿×Ó»¥×÷ÓëÖ×Áöϸ°ûÔöÖ³¡£»£»úÖÆÉÏ£¬£¬×ªÂ¼Òò×ÓMEIS1Æ«ºÃÁ¬Ïµ·çÏÕµÈλ»ùÒò²¢Éϵ÷SOX18£¬£¬Ðγɡ°rs2297440¨CMEIS1¨CSOX18¡±´ÙÖ×Áö»úÖÆ¡£
±¾Ñо¿ÌṩÁ˽ºÖÊÁöÔöÇ¿×ÓÅþÁ¬×é×ÊÔ´£¬£¬ÆÊÎö·Ç±àÂë±äÒìÔõÑùÖØËÜÔ¶³Ìµ÷¿Ø²¢Íƶ¯Ö×ÁöÏ£Íû£¬£¬Îª¾«×¼ÖÎÁÆÌṩDZÔڰе㡣

Á¥ÊôµÚÒ»Ò½ÔºÂÀÍò¸ï½ÌÊÚ¡¢ÕÅåó½ÌÊÚºÍËÕ¹âËɸ±½ÌÊÚΪ¸ÃÂÛÎĵÄͨѶ×÷Õߣ¬£¬Á¥ÊôµÚÒ»Ò½Ôº²©Ê¿ºó±Ï½ø·½¡¢ÄªÎ°Åô¡¢ÄÏ¿ª´óѧÒѽáÒµ²©Ê¿ÉúÁõÂúΪ¸ÃÂÛÎÄÅäºÏµÚÒ»×÷Õß¡£
ÂÛÎÄÁ´½Ó£ºhttps://www.nature.com/articles/s41556-025-01737-3