ngµç×ÓÓÎÏ·

05

¿ÆÑÐÏ£Íû

Çñΰ¡¢ ¡¢²Ìε¡¢ ¡¢ÊæÑÂÇåÍŶÓÕ¹ÏÖ×ÔÉíÃâÒßÄÔÑ×ѪÄÔÆÁÕÏÆÆËðлúÖÆ

¸å¼þȪԴ£º£ºÁ¥ÊôµÚÈýÒ½Ôº ±à¼­£º£ºÎâÁ¢¼á ÉóºË£º£ºËïÒ«±ó É󶨣º£º»ÆÑÞ ÔĶÁÁ¿£º£º

ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶£¨Í¨Ñ¶Ô±ÊæÑÂÇ壩¿ËÈÕ £¬£¬Á¥ÊôµÚÈýÒ½ÔºÄÔ²¡ÖÐÐÄÇñΰ¡¢ ¡¢²Ìε¡¢ ¡¢ÊæÑÂÇåÍŶӽ«ÁÙ´²ÊÓ²ìÓë·Ö×Ó»úÖÆÑо¿ÏàÁ¬Ïµ £¬£¬ÆÊÎöÁËÍâÖÜËèϵµ¥ºËϸ°ûÔÚ×ÔÉíÃâÒßÄÔÑ×µÄ×÷ÓûúÖÆ £¬£¬·¢Ã÷µ¥ºËϸ°ûÇý¶¯µÄIRF7ͨ·ÊÇ¿¹NMDARÄÔÑ×ÖÐѪÄÔÆÁÕϲ¡ÀíÀú³ÌµÄ½¹µã¡£Ïà¹ØÑо¿Ð§¹û½ÒÏþÓÚ¹ú¼Ê×ÅÃûÃâÒßѧÆÚ¿¯Brain, Behavior, and Immunity¡£

¿¹N-¼×»ù-D-Ì춬°±ËáÊÜÌ壨NMDAR£©ÄÔÑ×ÊÇÒ»ÖÖÑÏÖØµÄ×ÔÉíÃâÒßÐÔÉñ¾­ÏµÍ³¼²²¡ £¬£¬Ò²ÊÇ×ÔÉíÃâÒßÄÔÑ×ÖÐ×î³£¼ûµÄÒ»ÖÖÀàÐÍ¡£¸Ã²¡µÄ²¡Òò¼°·¢²¡»úÖÆÉв»ÍêÈ«ÇåÎú £¬£¬ÏÖ½×¶ÎÖ÷ÒªÓèÃâÒßµ÷ÀíÖÎÁÆ £¬£¬È±·¦Õë¶ÔÐÔÖÎÁÆÊֶΡ£²¿·Ö»¼ÕßÔ¤ºó¼«²î £¬£¬²»µ«¸ø»¼ÕßÉúÑÄÊÂÇéÔì³ÉÑÏÖØµÄÓ°Ïì £¬£¬Í¬Ê±Ò²¸ø»¼Õß¼ÒÍ¥ºÍÉç»á´øÀ´Á˼«Öصļ縺¡£Òò´Ë £¬£¬¾Û½¹¿¹NMDARÄÔÑ׵ķ¢²¡»úÖÆ £¬£¬Ñ°ÕÒеÄÖÎÁưеãÓÈΪÆÈÇС£

ѪÄÔÆÁÕÏ£¨blood-brain barrier £¬£¬BBB£©ÆÆËðÊÇ¿¹NMDARÄÔÑ×·¢²¡µÄÒªº¦ÒòËØÖ®Ò» £¬£¬ÆäÖе¥ºËϸ°ûÔÚÔö½øBBBÆÆËðÀú³ÌÖÐÆðÁËÖ÷Òª×÷Óà £¬£¬µ«Ïêϸ»úÖÆ²»Ïê¡£Òò´Ë £¬£¬ÉîÈë̽ÌÖ¿¹NMDARÄÔÑ×µÄBBBÆÆËð»úÖÆ £¬£¬¹ØÓÚÆÊÎö¼²²¡µÄ·¢²¡»úÖÆ £¬£¬²¢¿ª·¢¾«×¼ÖÎÁưеã¾ßÓÐÖ÷ÒªÒâÒå

¸ÃÑо¿²»µ«ÉÁ˶Ô×ÔÉíÃâÒßÄÔÑ×±¬·¢¿ªÕ¹µÄÃ÷È· £¬£¬¸üΪδÀ´¿ª·¢°ÐÏòIRF7ͨ·µÄ¾«×¼Õï¶ÏºÍÐÂÐÍÖÎÁÆÕ½ÂÔµÓÚ¨Á˼áʵµÄÀíÂÛ»ù´¡ £¬£¬¾ßÓÐÖ÷ÒªµÄÁÙ´²×ª»¯Ô¶¾°¡£

Á¥ÊôµÚÈýÒ½ÔºÄÔ²¡ÖÐÐÄÀîÆô»Û˶ʿÑо¿Éú¡¢ ¡¢Ð¤Àö¸±Ö÷ÈÎҽʦ¡¢ ¡¢À·¼¸±Ö÷ÈÎҽʦ¡¢ ¡¢»Æ¬r˶ʿÑо¿ÉúΪ¸ÃÂÛÎÄÅäºÏµÚÒ»×÷Õß £¬£¬ÄÔ²¡ÖÐÐÄÇñΰ½ÌÊÚ¡¢ ¡¢²Ìε¸±Ñо¿Ô±¡¢ ¡¢ÊæÑÂÇåÖ÷ÈÎҽʦΪÅäºÏͨѶ×÷Õß¡£¸ÃÑо¿»ñµÃÁË»ªÄÏũҵ´óѧËï¼á¡¢ ¡¢½­Î÷ÖÐÒ½Ò©´óѧÅí¸»»ªµÈר¼ÒµÄÖ§³Ö¡£

Ô­ÎÄÁ´½Ó https://doi.org/10.1016/j.bbi.2025.07.026


¡¾ÍøÕ¾µØÍ¼¡¿