ngµç×ÓÓÎÏ·ÐÂÎÅÍøѶ£¨Í¨Ñ¶Ô±ÕŻ۶«£©¿ËÈÕ£¬ngµç×ÓÓÎÏ·Á¥ÊôµÚ°ËÒ½ÔºÕŻ۶«½ÌÊÚÍŶÓÔÚÇéÐκͿµ½¡¹ú¼Ê×ÅÃûѧÊõÆÚ¿¯Environment International£¨ÇéÐοÆѧÓëÉú̬ѧ´óÀàÒ»Çø£¬IF 10.3£©ÉϽÒÏþÁËÌâΪ¡°BaP/BPDE suppresses homologous recombination repair in human trophoblast cells to induce miscarriage: the roles of lnc-HZ08¡±µÄÔ´´ÐÔʵÑéÑо¿Ð§¹û¡£¡£ÕâÏîÑо¿·¢Ã÷ÇéÐÎÎÛȾÎïBaP/BPDEͨ¹ýÉϵ÷lnc-HZ08¶øÒÖÖÆ×ÌÑøϸ°ûÖÐDNAË«Á´¶ÏÁÑ£¨DSB£©µÄͬԴÖØ×飨HR£©ÐÞ¸´£¬½ø¶øÒý·¢Á÷²ú¡£¡£
Ô½À´Ô½¶àµÄÑо¿ÏÔʾ£¬±½²¢[a]ÜÅ£¨BaP£©¼°Æä´úл²úÆ·±½²¢[a]ÜÅ-7,8-¶þÇâ¶þÑõ-9,10-»·Ñõ»¯ÎBPDE£©Ì»Â¶»áµ¼ÖÂ×ÌÑøϸ°û¹¦Ð§ÕÏ°¶øÒý·¢Á÷²ú¡£¡£DNAË«Á´¶ÏÁÑ£¨DSB£©µÄͬԴÖØ×飨HR£©ÐÞ¸´ÔÚά³ÖÒÅ´«ÎȹÌÐÔºÍϸ°ûÕý³£¹¦Ð§ÖÐÆð×ÅÖÁ¹ØÖ÷ÒªµÄ×÷Óᣡ£È»¶ø£¬BaP/BPDEÊÇ·ñ¿ÉÄÜÒÖÖÆÈË×ÌÑøϸ°ûÖÐHRÐÞ¸´¶øÒý·¢Á÷²ú£¬¼°ÆäDZÔڵıí¹ÛÒÅ´«µ÷¿Ø»úÖÆÍêÈ«²»ÇåÎú¡£¡£
±¾Ñо¿·¢Ã÷BaP/BPDEͨ¹ýÉϵ÷lnc-HZ08¶øÒÖÖÆ×ÌÑø²ãϸ°ûÖÐDSBµÄHRÐÞ¸´£¬½ø¶øÒý·¢Á÷²ú¡£¡£ÔÚ»úÖÆÉÏ£¬lnc-HZ08ͨ¹ýÈýÌõ;¾¶ÒÖÖÆ×ÌÑø²ãϸ°ûÖÐDSBµÄHRÐÞ¸´ £º£º¢Ùϵ÷FOXA1µÄ±í´ïˮƽ£¬´Ó¶øÒÖÖÆFOXA1½éµ¼µÄBRCA1ºÍCtIPµÄmRNAת¼£»£»£»¢Úͨ¹ýlnc-HZ08µÄµÚÒ»¸öƬ¶ÏÓëCtIP¾ºÕùÐÔÁ¬Ïµ£¬´Ó¶øÏ÷ÈõBRCA1ºÍCtIPÂÑ°×µÄÏ໥×÷Ó㻣»£»¢ÛÒÖÖÆBRCA1½éµ¼µÄCtIP·ºËØ»¯¡£¡£ÔÚBaP̻¶µÄСÊóÁ÷²úÄ£×ÓÖУ¬Ôö²¹Ctip¿ÉÒÔÓÐÓõػָ´£¨¼´ÔöÌí£©HRÐÞ¸´Ð§Âʲ¢¼õÇáÁ÷²ú¡£¡£±¾Ñо¿²»µ«Õ¹ÏÖÁËBaP/BPDE̻¶¡¢HRÐÞ¸´ÕÏ°Óë²»Ã÷²¡ÒòÁ÷²úÖ®¼äµÄÏà¹ØÐÔºÍÒò¹û¹Øϵ£¬»¹Õ¹ÏÖÁËlnc-HZ08µ÷¿ØµÄBRCA1/CtIP½éµ¼µÄHRÐÞ¸´µÄлúÖÆ£¬ÎªBaP/BPDEÒý·¢µÄ²»Ã÷ÔÒòÁ÷²úµÄ·¢²¡»úÖƺÍÖÎÁÆÌṩÁËеÄDZÔÚÖÎÁưе㡣¡£
³ÂάÄÈ¡¢Âí³ÉÁú¡¢ÍõÂüÁ¦¡¢»ÆÐÄӱΪ¸ÃÂÛÎĵÄÅäºÏµÚÒ»×÷Õߣ¬ÄÏ·½Ò½¿Æ´óѧÁ¥ÊôÉîÛÚ¸¾Ó×±£½¡ÔºÕÔµÂÅô¡¢ngµç×ÓÓÎÏ·Á¥ÊôµÚ°ËÒ½ÔºÕŻ۶«Îª¸ÃÂÛÎĵÄÅäºÏͨѶ×÷Õß¡£¡£ngµç×ÓÓÎÏ·Á¥ÊôµÚ°ËҽԺΪµÚÒ»×÷Õߺ͵ÚһͨѶµ¥Î»¡£¡£
±¾ÂÛÎÄÊܵ½¹ú¼Ò×ÔÈ»¿Æѧ»ù½ðÃæÉÏÏîÄ¿¡¢¹ã¶«Ê¡ÔÁÉîÇøÓòÁªºÏ»ù½ðÖصãÏîÄ¿¡¢ÉîÛÚÊÐҽѧÑо¿×¨Ïî×ʽðÏîÄ¿¡¢ÉîÛÚÊпƴ´Î¯»ù´¡Ñо¿ÃæÉÏÏîÄ¿¡¢¸£ÌïÇøÎÀÉú¹«ÒæÐÔ¿ÆÑÐÏîÄ¿ºÍÖÐÑë¸ßУ»£»£»ù±¾¿ÆÑÐÓªÒµ¾·ÑµÈ»ù½ðµÄ×ÊÖú¡£¡£
ÂÛÎÄÁ´½Ó £º£ºhttps://doi.org/10.1016/j.envint.2024.108975
µØµã:¹ãÖÝÊÐиÛÎ÷·135ºÅ Óʱà:510275
µç»°: 020-84112828
ngµç×ÓÓÎÏ·°æȨËùÓÐ COPYRIGHT?1999-2022 , SUN YAT-SEN UNIVERSITY