ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶£¨Í¨Ñ¶Ô±ÐÜÀöÄÈ£©·ÅÉäÐÔÖ±³¦²¡£¡£¨RP£©ÊÇÅèÇ»¶ñÐÔÖ×Áö£¨ÈçǰÏßÏÙ¡¢¡¢¡¢Ö±³¦ºÍ×Ó¹¬Ö×ÁöµÈ£©·ÅÉäÖÎÁƺóµÄ³£¼û¸±×÷Ó㬣¬·¢²¡Âʸߣ¬£¬¶øÁÙ´²ÉÏȱ·¦ÓÐÓõÄÖÎÁÆÒªÁì¡£¡£·øÉä»áµ¼Ö³¦µÀ¾úȺµÄʧµ÷£¬£¬È»¶ø£¬£¬RPÖмÓÈëËÞÖ÷-΢ÉúÎïȺÏ໥×÷ÓõĹ²´úл²úÆ·ºÍµ÷ÀíÍøÂçÌØÕ÷ÉÐδÆÊÎö¡£¡£
ÉúÃü¿ÆÑ§Ñ§ÔºÂ½Ó¾ü½ÌÊÚÍŶÓÓëÁ¥ÊôÁùÔºÍõ»Ô½ÌÊÚÍŶÓʹÓÃRPСÊóÄ£×ӺͶà×éѧսÂÔÀ´±íÕ÷³¦µÀ¾úȺ¼°Æä´úлÎïÓëËÞÖ÷ÃâÒßϵͳµÄÏ໥×÷Ó㬣¬ÒÔÕ¹ÏÖ³¦µÀ¾úȺͨ¹ýÆä¹²´úл²úÆ·¼ÓÈë·øÉä±£»£»£»¤µÄ»úÖÆ¡£¡£´úл×éѧЧ¹ûÏÔʾ£¬£¬RPСÊóºÍ·ÅÉäÖÎÁÆ»¼Õߵķà±ãºÍѪÇåÖ㦵À¹²´úлÎï3-ôÇ»ù¶¡Ëᣨ3HB£©Å¨¶ÈÏÔÖø½µµÍ£¬£¬ÇÒÓë´ÙÑ×Òò×ÓIL6µÄ±í´ïˮƽ¸ºÏà¹Ø£»£»£»ÔÚ´Ë»ù´¡ÉÏ£¬£¬Ñо¿ÍŶӽøÒ»²½ÆÊÎöÁË3HBÔÚ³¦µÀÑ×Ö¢ºÍ×éÖ¯ËðÉËÖÐʩչµÄ·øÉä±£»£»£»¤×÷Óü°Æä»úÖÆ£¬£¬¼´3HBͨ¹ýϵ÷RPСÊóÖÐGÂѰ׿ÁªÊÜÌå43£¨GPR43£©½éµ¼µÄIL6±í´ï£¬£¬ÏÔÖø¸ÄÉÆ·øÉäÓÕµ¼µÄËðÉË¡£¡£±ðµÄ£¬£¬Î¢ÉúÎï×éÆÊÎöÏÔʾ£¬£¬Óëδ¾ÖÎÁƵıÈÕÕ×éÏà±È£¬£¬·øÉä»áµ¼ÖÂRPСÊóºÍ·ÅÉäÖÎÁÆ»¼Õß³¦µÀÖÐDZÔÚÒæÉú¾úAkkermansia muciniphilaƷòÏÔÖøïÔÌ£»£»£»Ð¡Êó¹àθA. muciniphilaÏÔÖøÔöÌí3HBŨ¶È£¬£¬Ïµ÷GPR43ºÍIL6µÄ±í´ï£¬£¬²¢¸ÄÉÆ·øÉäËðÉË¡£¡£ÒÔÉÏЧ¹ûÅú×¢£¬£¬·øÉäÓÕµ¼µÄ³¦µÀ¾úȺºÍ´úлʧµ÷ÓëRPµÄ·¢²¡»úÖÆÓйأ¬£¬°ÐÏò¡°³¦µÀ-ÃâÒß¡±ÖáµÄ;¾¶¿ÉÏÔÖø¸ÄÉÆ·øÉäºó×éÖ¯ËðÉË¡£¡£¸ÃÑо¿ÎªÁÙ´²¼õÇá·øÉäÓÕµ¼µÄËðÉËÌṩÁËеÄÔ¤·ÀºÍÖÎÁÆÕ½ÂÔ¡£¡£

¸ÃÑо¿ÓÚ2024Äê5ÔÂ14ÈÕÒÔ¡°Gut Microbiota-Derived 3-Hydroxybutyrate Blocks GPR43-Mediated IL6 Signaling to Ameliorate Radiation Proctopathy¡± ΪÌâÔÚAdvanced ScienceÉϽÒÏþ£¬£¬ngµç×ÓÓÎÏ·ÉúÃü¿ÆÑ§Ñ§Ôº¸ðÕñ»Í¸±Ñо¿Ô±Îª¸ÃÎÄÕµĵÚÒ»×÷Õߣ¬£¬Â½Ó¾ü½ÌÊÚ¡¢¡¢¡¢Íõ»³Ã÷¸±½ÌÊÚºÍÍõ»Ô½ÌÊÚΪ¸ÃÎÄÕµÄÅäºÏͨѶ×÷Õß¡£¡£º£ÏàÖúÍŶӵijÉÔ±¶Ô¸ÃÎÄÕÂ×ö³öÁËТ˳¡£¡£
ÔÎÄÁ´½Ó£º£ºhttp://doi.org/10.1002/advs.202306217