ngµç×ÓÓÎÏ·ÐÂÎÅÍøѶ£¨Í¨Ñ¶Ô±ÊæÑÂÇ壩¿ËÈÕ£¬£¬£¬Á¥ÊôµÚÈýÒ½ÔºÄÔ²¡ÖÐÐÄÉñ¾ÃâÒßÍŶÓÔÚÉñ¾²¡Ñ§Æì½¢ÆÚ¿¯Annals of Neurology£¨ÖпÆÔºÒ»ÇøTop£¬£¬£¬IF=11.2£©½ÒÏþÁËÌâΪ ¡°Autoimmune glial fibrillary acidic protein astrocytopathy is associated with HLA-A*3303 and HLA-DPB1*0501¡±µÄÑо¿ÂÛÎÄ¡£¡£¸ÃÑо¿ÓÉÁ¥ÊôµÚÈýÒ½ÔºÄÔ²¡ÖÐÐÄÉñ¾ÃâÒßÍŶÓÁªºÏµÂ¹úBorstelÑо¿ÖÐÐļ°º£Äϸ¾Å®¶ùͯҽѧÖÐÐĵȺ£ÄÚÍâ16¼Òµ¥Î»ÅäºÏÍê³É¡£¡£ÄÔ²¡ÖÐÐÄÊæÑÂÇåΪÂÛÎĵÚÒ»×÷Õߣ»£»£»Á¥ÊôµÚÈýÒ½Ôº¿Í×ù½ÌÊÚ¡¢µÂ¹úBorstelÑо¿ÖÐÐÄÓàлª£¬£¬£¬ÄÔ²¡ÖÐÐÄÇñΰΪÂÛÎÄÅäºÏͨѶ×÷Õß¡£¡£
×ÔÉíÃâÒßÐÔ½ºÖÊÏËάËáÐÔÂÑ°×ÐÇÐνºÖÊϸ°û²¡£¡£¨GFAP-A£©ÊÇÒ»ÖÖÐÂÐ͵ÄÉñ¾ÏµÍ³×ÔÉíÃâÒß²¡£¬£¬£¬ÁÙ´²ÌåÏÖΪÄÔĤ¡¢ÄÔʵÖÊ¡¢¼¹Ëè¡¢ÊÓÉñ¾¡¢ÖÜΧÉñ¾ÊÜÀÛ¡£¡£GFAP-AÊôÓÚÓÐÊý²¡£¬£¬£¬ºÃ·¢ÓÚÇà׳Ä꣬£¬£¬ÁÙ´²ÒìÖÊÐÔÇ¿£¬£¬£¬»úÖƲ»ÇåÎú£¬£¬£¬¼«Ò×ÎóÕïÇÒÔ¤ºó²î£¬£¬£¬¸ø¼ÒÍ¥ºÍÉç»á´øÀ´¼«Öؼ縺¡£¡£Òò´Ë£¬£¬£¬ÆÊÎö¸Ã²¡·¢²¡²¡ÒòÓë»úÖÆÉõΪҪº¦¡£¡£
±¾Ñо¿ÔÚ¹ú¼ÊÉÏÂÊÏȶÔGFAP-A¼²²¡HLA»ùÒò¾ÙÐÐÅжÏÆÊÎö£¬£¬£¬·¢Ã÷GFAP-A·¢²¡Ò׸ÐÐÔÏà¹ØµÄ»ùÒò£º£ºHLA-A*3303ºÍHLA-DBP1*0501¡£¡£ÁíÍ⣬£¬£¬³ýÁ˺ͼ²²¡µÄÒ׸ÐÐÔÏà¹ØÍ⣬£¬£¬HLA-A*3303»¹ºÍÁÙ´²Ö¸±êÏÔÖøÏà¹Ø£¬£¬£¬ÌáÐÑÕâÒ»HLA- IÀà·Ö×Ӻͼ²²¡µÄÑÏÖس̶ȺÍ/»ò¶ÔÖÎÁƵķ´Ó³Ïà¹Ø¡£¡£
ͨ¹ý¶ÔHLA»ùÒò·ÖÐÍ·¢Ã÷£¬£¬£¬GFAP-A¼²²¡Ò׸ÐÐÔºÍHLA-A*3303 (OR = 2.02, 95% CI = 1.32 ¨C 3.06, P = 0.00072, Padj. = 0.046) ÒÔ¼°HLA-DBP1*0501 (OR = 0.51, 95% CI = 0.36 ¨C 0.71, P = 0.000048, Padj. = 0.0062) ÏÔÖøÏà¹Ø¡£¡£
½øÒ»²½ÆÊÎö·¢Ã÷£¬£¬£¬ºÍ²»Ð¯´øHLA-A*3303µÄGFAP-A»¼ÕßÏà±È£¬£¬£¬Ð¯´øHLA-A*3303µÄGFAP-A»¼ÕßÁÙ´²Ö¸±êÒ²±£´æÏÔÖø²î±ð£¬£¬£¬ÀýÈçסԺʱ³¤¸ü³¤£¬£¬£¬ÑªÌÇˮƽ¸ü¸ßµÈ£¨Í¼1£©¡£¡£
ͼ1 HLA-A*33ÓëÁÙ´²Ö¸±êסԺʱ¼äÒÔ¼°ÑªÌÇˮƽµÄ¹Øϵ
×îºó£¬£¬£¬Ñо¿Ö°Ô±Ô¤²âÁËGFAPÂÑ°×ÖÐÓëHLA-A*3303ºÍDPB1*0501ÕâÁ½¸ö¼²²¡Ïà¹ØHLA·Ö×ÓÁ¬ÏµµÄëĶΣ¬£¬£¬²¢ÇÒ¶ÔÕâЩëĶÎÓëÏìÓ¦µÄHLA·Ö×ÓµÄÏ໥×÷ÓþÙÐÐÁËÈýά½á¹¹µÄÄ£ÄâÆÊÎö£¨Í¼2£©¡£¡£
ͼ2 HLA-GFAPÂÑ°×Ï໥×÷ÓõÄÈýά½á¹¹Ä£Äâ
±¾Ñо¿ÌáÐÑ×ÔÉí·´Ó³ÐÔTϸ°û (ÓÈÆäÊÇCD8+ T ϸ°û) ¼ÓÈëÁËGFAP-A¼²²¡µÄ±¬·¢ºÍÏ£Íû¡£¡£Òò´Ë£¬£¬£¬¸ÃÑо¿Ê×´ÎÕ¹ÏÖHLAµÈÒÅ´«ÒòËØÔÚGFAP-A·¢²¡ÖеÄ×÷Ó㬣¬£¬²»µ«ÎªGFAP-AÒÅ´«ÃâÒßÑо¿µÓÚ¨»ù´¡£¬£¬£¬»¹ÎªÁÙ´²¾«×¼ÖÎÁÆGFAP-AÌṩÐÂ˼Ð÷¡£¡£
½üÄêÀ´£¬£¬£¬ÄÔ²¡ÖÐÐÄÇñΰ¡¢ÊæÑÂÇå¿ÎÌâ×éÒ»Ö±ÖÂÁ¦ÓÚ×ÔÉíÃâÒßÐÔÄÔÑ×ÕâÒ»ÀàÓÐÊý²¡ÁÙ´²Óë»ù´¡Ñо¿¡£¡£ÁªºÏº£ÄÚÙÉÐУ¬£¬£¬½¨ÉèÁÙ´²ÐÐÁУ¬£¬£¬¿ÎÌâ×é´ÓÒÅ´«²¡Òòѧ¡¢»úÖÆ¡¢Õï¶Ï±ê¼ÇÎïµÈ¶àά¶È¾ÙÐÐÉîÈë̽ÌÖ£¬£¬£¬È¡µÃÁËһϵÁÐÔ´´ÐÔÑо¿Ð§¹û£º£ºÊ״η¢Ã÷ÁË×ÔÉíÃâÒßÄÔÑ×˯ÃßÏà¹ØµÄÄÔµçÉúÎï±ê¼ÇÎNeurology£¬£¬£¬2024£¬£¬£¬ÒÑÎüÊÕ£©£»£»£»Ê״ι¹½¨NMDARÄÔÑ×µÄÈËÔ´»¯Ð¡ÊóÄ£×Ó£¨Journal of Neuroinflammation£¬£¬£¬2023£©£»£»£»Ê״ᨵÀNMDARÄÔÑ×Ò׸лùÒòHLA_DRB1*16:02£¨Journal of Neurology, Neurosurgery, and Psychiatry£¬£¬£¬2019£©µÈ¡£¡£Î´À´£¬£¬£¬Á¥ÊôµÚÈýÒ½ÔºÄÔ²¡ÖÐÐĽ«¼ÌÐøÒÀÍйú¼ÒÉñ¾ÇøÓòÒ½ÁÆÖÐÐÄ£¨ÖÐÄÏÇø£©µÄ½¨É裬£¬£¬È«Á¦Ê©Õ¹Éñ¾ÃâÒßÍŶӵÄÑÇר¿ÆÓÅÊÆ£¬£¬£¬Æð¾¢Ó뺣ÄÚ¡¢ÍâÑóÙÉÐÐÏàÖúÑо¿£¬£¬£¬Ôö½øÕïÁÆˮƽÌáÉý£¬£¬£¬¸üºÃÖª×ãÈËÃñȺÖÚ¿µ½¡ÐèÇ󡣡£
ÔÎÄÁ´½Ó: https://doi.org/10.1002/ana.26899
µØµã:¹ãÖÝÊÐиÛÎ÷·135ºÅ Óʱà:510275
µç»°: 020-84112828
ngµç×ÓÓÎÏ·°æȨËùÓÐ COPYRIGHT?1999-2022 , SUN YAT-SEN UNIVERSITY