ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶£¨Í¨Ñ¶Ô±ÐÜÀöÄÈ£©ÔÚ³ÉÊìµÄ¶àϸ°ûÉúÎïÌåÄÚ£¬£¬¾ßÓÐÌØ¶¨¹¦Ð§µÄϸ°ûȺͨ³£Ô´×ÔÓÚÒ»×é׿ÏÈϸ°û¡£¡£¡£Ï¸°ûȺÌåµÄÆ×ϵ¶àÑùÐÔÊÇÓÉÕâÐ©×æÏ¸°ûµÄÊýÄ¿¾öÒéµÄ£¬£¬Òò´ËÔ¤¼Æ×æÏÈϸ°ûȺÌåÊýÄ¿ÊÇ·¢ÓýÉúÎïѧµÄÖ÷ÒªÑо¿ÎÊÌâÖ®Ò»¡£¡£¡£¶ø¹Å°åµÄÑо¿ÊÖ¶ÎÖ÷ÒªÒÀÀµÓÚ×éÖ¯ÌØÒìÐÔµÄÆô¶¯×ӽ鵼±¨¸æ»ùÒòµÄ±í´ï£¬£¬½ø¶ø¶ÔÄ¿µÄϸ°ûȺÌå¾ÙÐмÆÊý¡£¡£¡£ÕâÒ»ÀàÑо¿ÊֶεĿɿ¿ÐԸ߶ÈÒÀÀµÓÚÆô¶¯×ÓµÄÑ¡Ôñ£¬£¬ÆäÖУ¬£¬Æô¶¯×ÓµÄ×éÖ¯ÌØÒìÐÔÓëʱ¿Õ±í´ï¶¯Ì¬¶¼»áʹԤ¼ÆÐ§¹û±¬·¢Îó²î¡£¡£¡£
2024Äê2ÔÂ20ÈÕ£¬£¬ngµç×ÓÓÎÏ·ÉúÃü¿ÆÑ§Ñ§ÔººØÐÛÀ׿ÎÌâ×éÔÚNature MethodsÉϽÒÏþÁËһƪÌâΪA statistical method for quantifying progenitor cells reveals incipient cell fate commitmentsµÄÑо¿ÎÄÕ¡£¡£¡£¸ÃÑо¿»ùÓÚ½üÄêÀ´Öð½¥³ÉÊìµÄϸ°ûÆ×ϵ׷×ÙÊÖÒÕ¹¹½¨µÄ·¢Óýϸ°ûÆ×ϵÊ÷ (developmental cell phylogeny)£¬£¬Á¬ÏµÈºÌåÒÅ´«Ñ§µÄ¾µäËÝ׿ÀíÂÛ (coalescent theory) Í·ÄÔ£¬£¬½¨ÉèÁËÒ»ÖÖÔ¤¼Æ×æÏÈϸ°ûȺÌå¾ÞϸµÄͳ¼ÆÒªÁìTarCA (targeting coalescent analysis)£¬£¬ÒÔ´ËÀ´Ñо¿ÅßÌ¥·¢ÓýÀú³ÌÖÐϸ°ûȺÌåµÄ¶¯Ì¬×ª±ä¡£¡£¡£
¸ø¶¨Ò»¿Å°üÀ¨¶àÖÖϸ°ûÀàÐ͵Äϸ°ûÆ×ϵÊ÷£¬£¬ËüµÄ×îºó½Úµã´ú±íÁ˱»²ÉÑùµÄϸ°û£¬£¬¶øÖÐÐĽڵãÔòÌåÏÖ׿ÏÈϸ°û¡£¡£¡£ÈôÊÇÒ»ÆäÖÐÐĽڵãµÄËùÓÐ×Ó´úϸ°û¾ùΪÏàͬµÄϸ°ûÀàÐÍ£¬£¬Ñо¿Ö°Ô±½«Æä½ç˵Ϊϸ°ûÀàÐÍÌØÒìµÄµ¥Ïµ·ÖÖ§ (monophyletic clade)¡£¡£¡£Ëæºó£¬£¬Ñо¿Ö°Ô±Æ¾Ö¤µ¥Ïµ·ÖÖ§µÄ¾ÞϸÂþÑÜÅÌËã³öËæ»úÁ½¸öϸ°û¾ùÀ´×Ôͳһµ¥Ïµ·ÖÖ§µÄ¸ÅÂÊ£¬£¬¶ø¸ÃÀàÐÍϸ°ûµÄ׿ÏÈϸ°ûȺÌåÊýÄ¿¼´Îª¸Ã¸ÅÂʵĵ¹Êý£¨Í¼1£©¡£¡£¡£

ͼ1 Ô¤¼Æ×æÏÈϸ°ûÊýÄ¿µÄ¹Å°åÒªÁìÓëTarCA
ͨ¹ýÅÌËã»úÄ£ÄâÊý¾Ý£¬£¬¸ÃÑо¿·¢Ã÷£¬£¬Óë¶Ôµ¥Ïµ·ÖÖ§¾ÙÐÐÖ±½Ó¼ÆÊýµÄÒªÁìÏà±È£¬£¬TarCA¶Ô²ÉÑùÂÊÒªÇó¸üµÍ£¬£¬²¢ÇÒÔÚʵÑéÔëÒô±£´æÊ±ÈÔÄܹ»¿ìËÙÊÕÁ²¡£¡£¡£ÕâÊÇÓÉÓÚÔÚTarCAËã·¨ÖУ¬£¬×Ó´úϸ°ûÊýÄ¿½ÏÉÙµÄ׿ÏÈϸ°ûÈ¨ÖØ½ÏµÍ£¬£¬´Ó¶øTarCAÄÜÎȹ̵ØÔ¤¼Æ³ö¶Ô×Ó´úϸ°ûȺÌå×ö³öÖ÷ҪТ˳µÄ׿ÏÈϸ°ûÊýÄ¿¡£¡£¡£Ëæºó£¬£¬Ñо¿Ö°Ô±ÔÚÏ߳桢¡¢¹ûÓ¬ÓëСÊóµÄϸ°ûÆ×ϵÊý¾ÝÖУ¬£¬ÑéÖ¤ÁËTarCAÔÚ´¦ÀíÕæÊµÉúÎïѧÊý¾ÝÖеĿɿ¿ÐÔ¡£¡£¡£ÒÔСÊóΪÀý£¬£¬Ñо¿Ö°Ô±·¢Ã÷²î±ð×éÖ¯µÄ׿ÏÈϸ°ûȺÌåÊýÄ¿ÔÚ¸öÌå¼ä¸ß¶ÈÒ»Ö¡£¡£¡£ÁíÍ⣬£¬³ý²ÉÑù»ñµÃµÄÖÕĩϸ°ûÀàÐÍÍ⣬£¬TarCA»¹ÄܶԷ¢Óý³õÆÚµÄÅßÌ¥½á¹¹£¨ÈçÈýÅ߲㼰ÅßÍâ×éÖ¯µÈ£©µÄ׿ÏÈϸ°ûȺÌåÊýÄ¿¾ÙÐÐÔ¤¼Æ£¬£¬½øÒ»²½Ö¤ÊµÎúTarCAµÄ¿É¿¿ÐÔÓë·ºÓÃÐÔ¡£¡£¡£
×îºó£¬£¬Ñо¿Ö°Ô±»¹½«TarCAÍØÕ¹ÖÁÔçÆÚϸ°ûÔËÆø¾öÒéÀú³ÌµÄÑо¿ÖС£¡£¡£ÔÚϸ°ûÔËÆø¾öÒéµÄ³õÆÚ£¬£¬ÈºÌåÄÚ²¿½öÓÐС²¿·ÖÇý¶¯»ùÒòµÄ±í´ï±¬·¢ÁËת±ä£¬£¬ÔÚȫת¼×éˮƽÒÀÈ»¼á³ÖÎȹ̣»Ëæ×Åϸ°ûÔËÆø¾öÒéµÄ¾ÙÐУ¬£¬Ï¸°ûȺÌåÄÚÖð½¥±¬·¢È«×ªÂ¼×éˮƽµÄ±í´ï²î±ð¡£¡£¡£ÔõÑùÔÚ»ùÒòˮƽ£¬£¬¶ø·Çȫת¼×éˮƽ£¬£¬¶Ô»ùÒò±í´ïÔÚϸ°ûȺÌåÖеÄÒìÖÊÐÔ¾ÙÐмì²â£¬£¬ÊÇÑо¿ÔçÆÚϸ°ûÔËÆø¾öÒéÀú³ÌµÄÒªº¦ÄÑÌ⣨ͼ2£©¡£¡£¡£Îª´Ë£¬£¬¸ÃÑо¿Ê¹ÓÃTarCAËã·¨¶Ô»ùÒò±í´ïˮƽÔÚϸ°ûÆ×ϵÊ÷ÉϵÄÒìÖÊÐÔ¾ÙÐÐÁËÆÀ¹À£¬£¬Ê¶±ð³öÁ˱í´ïˮƽÓëϸ°ûÆÆËéÀúÊ·ÊÂÎñżÁªµÄ»ùÒò£¨lineage-specific upregulated genes, LUGs£©¡£¡£¡£ÒÔСÊóÔçÆÚÅßÌ¥µÄ³¦¹Üϸ°ûΪÀý£¬£¬Ñо¿Ö°Ô±É¸Ñ¡³öÁË155¸öLUGs£¬£¬ÆäÖаüÀ¨ÖÚ¶à±ê¼Çǰ¡¢¡¢ÖС¢¡¢ºó³¦µÄÃ÷ÐÇ»ùÒò¡£¡£¡£Æ¾Ö¤LUGsÔÚ²î±ðϸ°ûÖеıí´ïÇéÐΣ¬£¬Ñо¿Ö°Ô±½øÒ»²½¹¹½¨³öСÊ󳦹ÜÏòÏÂÓÎÆ÷¹Ù·Ö»¯Àú³ÌµÄ²ã¼¶Ä£×Ó¡£¡£¡£¸ÃÄ£×ÓÖ¸³ö£¬£¬ÒÈÏÙ¡¢¡¢Ð¡³¦Óë½á³¦¼ä±£´æ¹²ÏíµÄ׿ÏÈ״̬£¬£¬ÓëÌåÍⶨÏò·Ö»¯ÊµÑéЧ¹ûÒ»Ö¡£¡£¡£

ͼ2 ½ç˵ϸ°ûÔËÆø·ÖÅäÀú³ÌÖеÄLUGs
×ܵÄÀ´Ëµ£¬£¬¸ÃÑо¿¿ª·¢µÄTarCAËã·¨¿É¶Ôí§Òâϸ°ûȺÌåÔ¤¼Æ×æÏÈϸ°ûÊýÄ¿£¬£¬¶øÎÞÐèÊÂÏÈ»ñµÃ×æÏ¸°ûµÄÏÈÑéÐÅÏ¢£¬£¬Ò²ÄÜÍÆËãÉÙÊýϸ°ûÖеÄÇý¶¯»ùÒò£¬£¬ÒÔ´ËÀ´Ô¤²âÔçÆÚϸ°ûÔËÆøµÄ·Ö»¯ÇãÏò¡£¡£¡£ÕâЩ·¢Ã÷˵Ã÷TarCAÄÜÔö½ø°üÀ¨ÈËÀàÔÚÄÚµÄËùÓÐÖØ´óÉúÎï×éÖ¯µÄÆ×ϵ¶àÑùÐÔµÄÁ¿»¯£¬£¬¶ÔÆä½¨É趨Á¿Ä£×ÓÖÁ¹ØÖ÷Òª£¬£¬¿ÉÒÔ×ÊÖúÈËÃǽâ¾ö¸öÌå·¢Óý¿ÉËÜÐÔºÍÐàÂõÏà¹ØµÄ×éÖ¯¹¦Ð§ÍË»¯µÄÎÊÌâ¡£¡£¡£ÕâÏîÊÂÇéÊǾµä½ø»¯ÉúÎïѧÓëÏÖ´úϸ°û·¢ÓýÉúÎïѧÈںϵÄÒ»¸ö¹æ·¶¡£¡£¡£
ngµç×ÓÓÎÏ·ÉúÃü¿ÆÑ§Ñ§ÔººØÐÛÀ×½ÌÊÚΪ¸ÃÂÛÎĵÄͨѶ×÷Õߣ¬£¬¿ÎÌâ×鲩ʿºóµËÉÆ¿¡Ó벩ʿ½áÒµÉú¹¨êÏΪÅäºÏµÚÒ»×÷Õß¡£¡£¡£¸ÃÑо¿»ñµÃÁ˹ú¼ÒÖØµãÑз¢ÍýÏëÓë¹ú¼Ò×ÔÈ»¿ÆÑ§»ù½ðµÄ×ÊÖú¡£¡£¡£
ÂÛÎÄÁ´½Ó£º£º£ºhttps://www.nature.com/articles/s41592-024-02189-7
TarCAËã·¨¹¤¾ßÁ´½Ó£º£º£ºhttps://github.com/shadowdeng1994/TarCA