ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶£¨Í¨Ñ¶Ô±Ò¶Ð¡Ý¼¡¢ÁÖΰ½Ü£©°¢¶û´Äº£Ä¬²¡£¡£¡£¨AD£©ÊÇÍíÄê³Õ´ô×î³£¼ûÐÎʽ£¬ÆäÌØµãÊÇÈÏÖª¹¦Ð§µÄ¾ÙÐÐÐԺͲ»¿ÉÄæ×ªÐÔµÄË¥ÍË¡£¡£¡£¾Ýͳ¼Æ£¬È«Çòƽ¾ùÿ3Ãë¾ÍÐÂÔöÒ»ÃûAD»¼Õߣ¬ÎÒ¹úAD»¼ÕßÊýÄ¿¸ß´ï980Íò¡£¡£¡£Ëæ×ÅÎÒ¹úÉú³ÝÀÏÁ仯Ç÷ÊÆ¼Ó¾ç£¬¿ª·¢ÓÐÓ÷½°¸Ô¤·ÀºÍÖÎÁÆAD±äµÃÓÈΪ½ôÆÈ¡£¡£¡£
½üÄêµÄÑо¿ÌáÐÑ£¬ÄÔѪ¹Ü¹¦Ð§ÕϰÊÇAD²¡ÀíÀú³ÌÖеÄÒ»¸öÖ÷ÒªÔçÆÚÊÂÎñ¡£¡£¡£Ñª¹ÜÄÚÆ¤Éú³¤Òò×ÓA£¨VEGFA£©ÔÚµ÷ÀíѪ¹ÜµÄ¶àÖÖÐÄÀí¹¦Ð§ºÍ²¡Àíת±äÖÐʩչ×ÅÒªº¦×÷Ó㬵«VEGFAÊÇ·ñ¼ÓÈëADÔçÆÚ²¡ÀíÏ£ÍûÉв»ÇåÎú¡£¡£¡£¿ËÈÕ£¬ngµç×ÓÓÎÏ·ÖÐɽҽѧԺҶСݼÍŶӡ¢ËïÒÝÏɼÍÄîÒ½ÔºÁÖΰ½ÜÍŶӺÍÌÆÑÇ÷ÍŶÓÁªºÏÔÚTranslational NeurodegenerationÆÚ¿¯½ÒÏþÌâΪ¡°Blockage of VEGF function by bevacizumab alleviates early-stage cerebrovascular dysfunction and improves cognitive function in a mouse model of Alzheimer¡¯s disease¡±µÄÑо¿ÂÛÎÄ¡£¡£¡£
¸ÃÂÛÎı¨µÀÁËÔÚÁÙ´²°©Ö¢ÖÎÁÆÖÐÓÃÓÚ¿¹Ñª¹ÜÌìÉúµÄµ¥¿Ë¡¿¹VEGFA¿¹Ìå±´·¥µ¥¿¹£¬¿ÉÏÔÖø¸ÄÉÆÔçÆÚADÄ£×ÓСÊóµÄ³¤Ê±³ÌÓ°Ïó£¬ïÔ̺£ÂíÄÔÇøºÍƤ²ãµí·ÛÑù°ß¿é³Á»ý£¬²¢ÒÖÖÆ½ºÖÊϸ°ûµÄ»î»¯¡£¡£¡£Ñо¿Ö°Ô±½øÒ»²½·¢Ã÷£¬ÔÚÔçÆÚADÄ£×ÓСÊóÖУ¬VEGFAÊÜÌåÂѰ׵ıí´ïˮƽ¾ßÓÐÐÔ±ð²î±ðÐÔת±ä£¬¶ø±´·¥µ¥¿¹¿ÉÒÔͨ¹ýÐÔ±ð²î±ðÐÔµ÷ÀíVEGFAÊÜÌåµÄ±í´ïˮƽ£¬Éϵ÷ÓëÄÔѪ¹Ü¹¦Ð§Ïà¹ØµÄ»ùÒò±í´ïºÍÐźÅͨ·£¬¸ÄÉÆÑªÄÔÆÁÕÏ£¬ÔöÇ¿ÄÔѪ¹Ü·´Ó³ÐÔ£¬²¢ïÔÌÖÐÐÔÁ£Ï¸°ûÔÚÄÔëϸѪ¹ÜÖеÄÖÍÁô¡£¡£¡£ÕâЩЧ¹ûÌáÐÑ£¬¡°ÀÏÒ©ÐÂÓᱵı´·¥µ¥¿¹ÔÚ¼õ»ºÔçÆÚADÀú³ÌÖоßÓнÏÇ¿µÄDZÁ¦£¬Ö¸³öÐÞ¸´ÄÔѪ¹Ü¹¦Ð§¿É×÷Ϊ¸ÉÔ¤ADÈÏÖªËðÉ˵ÄÖ÷Òª°ÐµãºÍÐÂÕ½ÂÔ¡£¡£¡£

Ñо¿Ê¾Òâͼ
ÖÐɽҽѧԺ2023Äê½áÒµµÄ²©Ê¿Ñо¿ÉúÕÅÃô¡¢ËïÒÝÏɼÍÄîÒ½Ôº2021¼¶²©Ê¿Ñо¿ÉúÕÅչΪÂÛÎĵÄÅäºÏµÚÒ»×÷Õß¡£¡£¡£ÁÖΰ½Ü½ÌÊÚ¡¢Ò¶Ð¡Ý¼½ÌÊÚºÍÌÆÑÇ÷½ÌÊÚΪÂÛÎĵÄÅäºÏͨѶ×÷Õß¡£¡£¡£
ÂÛÎÄÁ´½Ó£ºhttps://doi.org/10.1186/s40035-023-00388-4