ngµç×ÓÓÎÏ·

05

¿ÆÑÐÏ£Íû

½ÕýÆëÍŶӷ¢Ã÷FOXP3+¾ÞÊÉϸ°û¿ÉÒÖÖÆ¼±ÐÔȱѪÐÔÄÔ×äÖÐÓÕµ¼µÄÉñ¾­Ñ×Ö¢

¸å¼þȪԴ£º £ºÁ¥ÊôµÚÈýÒ½Ôº ±à¼­£º £ºÀîͯÖÛ¡¢Íõ¶¬Ã· ÉóºË£º £ºÏÄçø ÔĶÁÁ¿£º £º

ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶£¨Í¨Ñ¶Ô±²Ìε¡¢ºúÃÎÑÕ£©¿ËÈÕ£¬£¬ngµç×ÓÓÎÏ·Á¥ÊôµÚÈýÒ½ÔºÄÔ²¡ÖÐÐÄÉñ¾­ÄÚ¿ÆÂ½ÕýÆëÍŶÓÔÚ¹ú¼Ê×ÅÃûÆÚ¿¯Autophagy£¨IF13.391£©½ÒÏþÁËÌâΪ¡°FOXP3+ macrophage represses acute ischemic stroke-induced neural inflammation¡±µÄ×îÐÂÔ­´´ÐÔÑо¿¡£¡£¡£Ñо¿·¢Ã÷£¬£¬FOXP3+¾ÞÊÉϸ°û¿ÉÒÔÒÖÖÆ¼±ÐÔȱѪÐÔÄÔ×äÖÐÓÕµ¼µÄÉñ¾­Ñ×Ö¢¡£¡£¡£

¼±ÐÔȱѪÐÔÄÔ×äÖÐ(Acute ischemic stroke, AIS)ÊÇÒ»Ö־߱¸¸ßÖ²ÐÓë¸ßÖÂËÀÂʵÄÑÏÖØ¼²²¡£¬£¬²¢ÇÒÔÚÌìϹæÄ£ÄÚÆÕ±éÂþÑÜ¡£¡£¡£¸Ã¼²²¡µÄ²¡ÀíÀú³Ì¿É¸ÅÀ¨Îª£¬£¬ÄÔѪÁ÷µÄͻȻÖÐÖ¹²¢µ¼ÖÂÉñ¾­ÔªéæÃü£¬£¬ÆäÒýÆðµÄÑ×Ö¢»á½øÒ»²½¼Ó¾çȱѪ°ë°µ´ø²¡±ä¹æÄ£µÄÀ©´ó£¬£¬¼ÓÖØ»¼ÕߵIJ¡Çé¡£¡£¡£Òò´Ë£¬£¬ÓÐÒ»ÖÖÁÙ´²¿´·¨ÒÔΪ£¬£¬Í¨¹ýÊÊʱÓÐÓõØÒÖÖÆÄÔ×äÖкóÉñ¾­Ñ×Ö¢£¬£¬Îª×éÖ¯ÐÞ¸´ºÍÔÙÉúÌṩÓÐÀûµÄÇéÐΣ¬£¬¾ß±¸ÓÐʵ¼ùÒâÒåµÄÁÙ´²¼ÛÖµ¡£¡£¡£

ÔÚ΢¹Û²ãÃæ£¬£¬¾ÞÊÉϸ°ûÔÚAISÏà¹Ø²¡ÀíÐÄÀíÀú³ÌÖÐʩչ×ÅÒªº¦×÷Ó㬣¬Æä×÷Ϊ¿ìËÙ·´Ó³µÄÃâÒßϸ°û´ó×Ú½þÈóÄÔ×äÖв¡Ôî¡£¡£¡£Í¬Ê±£¬£¬ÔÚAISÖУ¬£¬¸Ãϸ°û¿Éͨ¹ý°ûÔá×÷ÓÃ(effercytosis)À´É¨³ýËðÉ˵Äϸ°û»òË鯬£¬£¬ÖÕֹϸ°ûéæÃüÒýÆðµÄÉñ¾­Ñ×Ö¢£¬£¬´Ó¶øÔö½øÄÚÎÈ̬µÄ»Ö¸´¡£¡£¡£È»¶ø£¬£¬Í¨¹ý¸Ä±ä¾ÞÊÉϸ°ûµÄ¹¦Ð§ÊôÐÔÀ´ÒÖÖÆÄÔ×äÖкóÉñ¾­Ñ×Ö¢µÄ·Ö×ÓÉúÎïѧ»úÖÆÉв»Ã÷È·¡£¡£¡£ÖµµÃ×¢ÖØµÄÊÇ£¬£¬FOXP3Êǵ÷ÀíÐÔTϸ°û(regulatory T cell, Treg)µÄÖ÷ÒªÃâÒßÒÖÖÆ×ªÂ¼Òò×Ó¡£¡£¡£åÇÀ´£¬£¬ÓÐÔ½À´Ô½¶àµÄÖ¤¾ÝÅú×¢£¬£¬FOXP3²¢²»ÊÜÏÞÓÚÔÚTϸ°ûÖеıí´ï£¬£¬ÆäÔÚ¾ÞÊÉϸ°ûÖÐÒàÓбí´ï¡£¡£¡£²Î¿¼FOXP3µÄ¹Å°å¹¦Ð§Óë×÷Ó㬣¬¸Ã·Ö×Ó¿ÉÄÜÊǵ÷Àí¾ÞÊÉϸ°ûÊôÐÔµÄÒªº¦½ÇÉ«¡£¡£¡£ÓÉ´Ë£¬£¬ÓÐÐëÒªÕö¿ªFOXP3ÔÚ¾ÞÊÉϸ°ûÖеĹ¦Ð§Ñо¿¡£¡£¡£

Ñо¿Í¨¹ý¹¹½¨ËèÏµÌØÒìÐÔFOXP3ÇóýСÊó(Lyz2 Cre-ERT2foxp3 fl/Y)¼°¶ÌÔÝÐÔ´óÄÔÖж¯Âö±ÕÈû(tMCAO)Ä£×ÓÑо¿ÁËFOXP3ÔÚAISÖоÞÊÉϸ°ûµÄ×÷Óᣡ£¡£¸ÃÑо¿±¨µÀÁËÔÚÖзçÄÔ¹£ËÀÖÜÎ§ÇøÓò±£´æFOXP3+¾ÞÊÉϸ°û¡£¡£¡£ÍŶÓͨ¹ýscRNAseqºÍ¶ÔFOXP3-ChIPµÄÆÊÎö£¬£¬·¢Ã÷FOXP3¾ßÓÐÕýÏòµ÷¿Ø¾ÞÊÉϸ°ûÍÌÊɺÍÍÌÊÉÎïÆÊÎö´úлµÄ¹¦Ð§¡£¡£¡£Óë¾ÞÊÉϸ°ûM1»òM2ÑÇȺ²î±ðµÄÊÇ£¬£¬FOXP3+¾ÞÊÉϸ°ûÌåÏÖ³öÔöÇ¿µÄ°ûÔá×÷ÓúͿ¹Ñ×ЧÂÊ¡£¡£¡£

ΪÑо¿ÔÚAISÖÐFOXP3Òò×Óµ÷¿Ø¾ÞÊÉϸ°û¹¦Ð§µÄ»úÖÆ£¬£¬ÍŶÓͨ¹ýÃâÒß¹²³Áµí(IP)ÊèÉ¢³öÔ­´ú×÷ÓýµÄ¹ÇËèȪԴµÄ¾ÞÊÉϸ°ûÖеÄFOXP3Á¬ÏµÂѰ×£¬£¬¾ÙÐÐÁËÒºÏàÉ«Æ×-ÖÊÆ×(LC-MS)ÆÊÎöºÍGO-BPÆÊÎö¡£¡£¡£Ð§¹û·¢Ã÷£¬£¬ÔÚ¾²Ï¢¾ÞÊÉϸ°ûÖУ¬£¬FOXP3¿ÉÎȹ̶øÉÙÁ¿µØ±í´ï£¬£¬µ«»áͨ¹ýLC3Ïà¹ØÍÌÊÉ×÷ÓÃ(LAP)µÄ×ÔÊÉ»úÖÆÒ»Ö±½µ½â¡£¡£¡£Ò»µ©¾ÞÊÉϸ°ûÓöµ½×äÖÐÏà¹Ø´Ì¼¤£¬£¬¾Í»áÆô¶¯LAP£¬£¬¾ºÕùÐÔµØÕ¼ÓÐ×ÔÊÉ»úÖÆ£¬£¬µ¼ÖÂFOXP3´Ó×ÔÊɽµ½âÖÐÊͷųöÀ´£¬£¬²¢×ªÔ˵½Ï¸°ûºËÖУ¬£¬Éϵ÷ÍÌÊɺÍÍÌÊÉÎïÆÊÎö´úлÏà¹Ø»ùÒòµÄת¼¡£¡£¡£ÕâÅú×¢FOXP3ÐźÅÊÇÓÉÒ»¸öÖØ´ó·Ö×ÓÍøÂçÇÉÃϸÄ嵨¾ÙÐпØÖÆ£¬£¬²¢ÇÒ¸ÃÍøÂç¿ÉÒÔ¿ìËÙ΢µ÷¾ÞÊÉϸ°ûÔÚAISÖеĻ¡£¡£¡£


DFA936FB34433D42691C9BD2945_75480BF3_1C487

FOXP3ÔÚ¾ÞÊÉϸ°ûÖÐ×÷ÓûúÖÆÊ¾Òâͼ


±¾Ñо¿Ô­´´ÐԵزûÎöÁËFOXP3ÔÚAIS¹£ËÀÇøÖÜΧµÄ¾ÞÊÉϸ°ûÖбí´ï£¬£¬²¢¿ÉÕýÏòµ÷Àí¾ÞÊÉϸ°ûµÄÍÌÊɺͿ¹Ñ×¹¦Ð§¡£¡£¡£Ñо¿½øÒ»²½·¢Ã÷ÔÚAISÖУ¬£¬FOXP3ÔÚ¾ÞÊÉϸ°ûÖеĿìËÙ¼¤»îÓëLC3Ïà¹ØÍÌÊÉ×÷ÓÃÏà¹Ø¡£¡£¡£ÓÉ´ËÌá³ö£¬£¬FOXP3ÊÇÒ»¸ö¾ß±¸Ç±ÔÚÑо¿¼ÛÖµµÄ·Ö×Ӱб꣬£¬ÆäÔÚȱѪÄÔ×éÖ¯ÖоßÓÐÔöÇ¿¾ÞÊÉϸ°û°ûÔá×÷Ó㬣¬²¢¿ÉÔö½øÑ×Ö¢ÏûÍË´Ó¶ø¼õÇáÄÔËðÉ˲¢Ôö½ø×äÖлָ´£¬£¬ÎªAISµÄÖÎÁÆÌṩÁËеÄÀíÂÛ»ù´¡ºÍ¸ÉÔ¤Õ½ÂÔ¡£¡£¡£

¸ÃÂÛÎÄͨѶ×÷ÕßΪngµç×ÓÓÎÏ·Á¥ÊôµÚÈýÒ½ÔºÄÔ²¡ÖÐÐĽÕýÆë½ÌÊÚ¡¢ÁÙ´²ÃâÒßѧÖÐÐijÑÒ½ÌÊÚ¼°ngµç×ÓÓÎÏ·Ö×Áö·ÀÖÎÖÐÐÄÁõÇ¿½ÌÊÚ¡£¡£¡£µÚÒ»×÷ÕßΪngµç×ÓÓÎÏ·Á¥ÊôµÚÈýÒ½ÔºÄÔ²¡ÖÐÐIJÌε¸±Ñо¿Ô±¡¢Éñ¾­ÄڿƲ©Ê¿Ñо¿ÉúºúÃÎÑÕ¡£¡£¡£

ÂÛÎÄÁ´½Ó£º £ºhttps://doi.org/10.1080/15548627.2022.2116833

¡¾ÍøÕ¾µØÍ¼¡¿