ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶£¨Í¨Ñ¶Ô±Ð¤ÊË£©Ï¸°û×ÔÊÉÊÇÕæºËÉúÎïά³Öϸ°ûÄÚÇéÐÎÎÈ̬¡¢¡¢¡¢°ü¹ÜÓªÑøÄÜÁ¿³ÖÐø¹©Ó¦µÄÒªº¦ÉúÎïѧÀú³Ì£¬£¬£¬ÔÚµ÷¿ØÏ¸°ûÉú³¤·¢Óý¡¢¡¢¡¢ÉúÎïºÍ·ÇÉúÎïÄæ¾³ÏìÓ¦ÖÐʩչÖ÷Òª×÷Óᣡ£¡£Ï¸°ûÔÚÓªÑøÄÜÁ¿È±·¦Ê±ÓÕµ¼×ÔÊɱ¬·¢£¬£¬£¬ÕâÒ»Àú³ÌÊܵ½Ò»ÏµÁÐ×ÔÊÉÏà¹ØÂѰף¨ATGs£©µÄ¸ß¶Èµ÷¿Ø¡£¡£¡£ÆäÖУ¬£¬£¬ÂѰ׼¤Ã¸ATG1ºÍATG13ÔÚ×ÔÊÉÓÕµ¼Ê±±»¼¤»î£¬£¬£¬ÐγÉÒ»¸öATG1-ATG13ÂѰ׼¤Ã¸¸´ºÏÎ£¬£¬´Ó¶øÆô¶¯×ÔÊÉÌåµÄÐγɡ£¡£¡£½üÄêÀ´£¬£¬£¬·ºËØ-ÂѰ×øÌå½éµ¼×ÔÊÉÏà¹ØÂѰ×ÎȹÌÐÔµ÷¿Ø×ÔÊÉÌåÐγÉͨ·µÄÑо¿È¡µÃÁËÖ÷ҪϣÍû£¬£¬£¬¿ÉÊÇÆù½ñΪֹ£¬£¬£¬¹ØÓÚ×ÔÊÉÂѰ׵ÄÁ×ËữºÍ·ºËØ»¯µÄ½»»¥µ÷¿Ø»úÖÆ»¹²»ÇåÎú¡£¡£¡£
ngµç×ÓÓÎÏ·ÉúÃü¿ÆÑ§Ñ§ÔºÐ¤Ê˽ÌÊÚ¿ÎÌâ×é̫ͨ¹ý×ÓÒÅ´«Ñ§ºÍÉúÎﻯѧÆÊÎö£¬£¬£¬·¢Ã÷ÌÖÂÛ·Ö×Ó14-3-3¦ËºÍ14-3-3¦ÊÓë×ÔÊÉÂѰ׼¤Ã¸¸´ºÏÌå³ÉÔ±ATG1-ATG13ºÍE3·ºËØÅþÁ¬Ã¸SINATsµÈ»¥×÷ÐγÉÂѰ×Öʸ´ºÏÌ壬£¬£¬½éµ¼SINATs¶ÔATG13µÄ·ºËØ»¯½µ½â¡£¡£¡£ÉîÈëÑо¿Åú×¢£¬£¬£¬ATG13aÂѰ×ÖÊÉÏ18¸öË¿°±ËáºÍËÕ°±Ëá²Ð»ù¹ØÓÚÆäÁ×Ëữ¼°×ÔÊɽ鵼µÄÓªÑøÈ±ÏÝ¿¹ÐÔÖÁ¹ØÖ÷Òª¡£¡£¡£½øÒ»²½Ñо¿ÏÔʾ£¬£¬£¬14-3-3sÂѰ×ÓëÁ×ËữATG13aµÄ»¥×÷ÔöÇ¿£¬£¬£¬Ôö½øSINATs½éµ¼Á×ËữATG13·ºËØ»¯½µ½â£¬£¬£¬²¢ÒÖÖÆATG1-ATG13¼¤Ã¸¸´ºÏÌåµÄÐγɡ£¡£¡£ÓëÆäÐÄÀí¹¦Ð§Ò»Ö£¬£¬£¬ÄâÄϽæ14-3-3¦Ë 14-3-3¦Ê˫ͻ±äÌåÌåÏÖ³öÑÓ³ÙÐàÂõ¡¢¡¢¡¢¶ÔÓªÑøÈ±ÏݵĿ¹ÐÔÔöÇ¿¼°×ÔÊÉÌåÐγÉÔö¶àµÄ±íÐÍ¡£¡£¡£

14-3-3ÂѰ׵÷¿ØÖ²Îï×ÔÊÉÆðʼµÄģʽͼ
¸ÃÑо¿ÒÔ¡°14-3-3 proteins contribute to autophagy by modulating SINAT-mediated degradation of ATG13¡±ÎªÌ⣬£¬£¬ÓÚ9ÔÂ2ÈÕÔÚ¹ú¼ÊȨÍþÆÚ¿¯The Plant CellÔÚÏß½ÒÏþ¡£¡£¡£ÂÛÎÄÊ×´ÎÆÊÎöÁËÖ²Îï14-3-3¦ËºÍ14-3-3¦ÊÔö½øSINAT¼Ò×åÂѰ×ͨ¹ý½éµ¼Á×ËữATG13ÂѰ׵ķºËØ»¯ÐÞÊκÍÎȹÌÐÔ£¬£¬£¬´Ó¶øµ÷¿ØÖ²Îï×ÔÊÉÆðʼµÄ·Ö×Ó»úÖÆ£¬£¬£¬¾ßÓÐÖ÷ÒªµÄ¿ÆÑ§ÒâÒ壨Qi et al., Plant Cell, 2022£©¡£¡£¡£
¸ÃÂÛÎÄÑо¿Êܵ½¹ú¼Ò×ÔÈ»¿ÆÑ§»ù½ðÇàÄê¿ÆÑ§»ù½ðÏîÄ¿¡¢¡¢¡¢¹ã¶«Ê¡ÖصãÁìÓòÑз¢ÍýÏëÏîÄ¿¡¢¡¢¡¢¹ã¶«Ê¡×ÔÈ»¿ÆÑ§»ù½ðÃæÉÏÏîÄ¿ºÍÁëÄÏÏÖ´úũҵ¿ÆÑ§ÓëÊÖÒչ㶫ʡʵÑéÊÒÏîÄ¿µÈ×ÊÖú¡£¡£¡£ÔÌØÆ¸Ñо¿Ô±Æë»ª£¨ÏÖÁëÄÏÏÖ´úũҵ¿ÆÑ§ÓëÊÖÒչ㶫ʡʵÑéÊÒÊׯ¸½ÌÊÚ£©¡¢¡¢¡¢½áҵ˶ʿÉúÀ×Ñ©ºÍÔÚ¶Á²©Ê¿ÉúÍõÑþΪÂÛÎĵÄÅäºÏµÚÒ»×÷Õߣ¬£¬£¬Ð¤Ê˽ÌÊÚΪÂÛÎĵÄ×ÔÁ¦Í¨Ñ¶×÷Õߣ¬£¬£¬Ïã¸ÛÖÐÎÄ´óѧ½ªÀïÎĽÌÊںͻªÄÏũҵ´óѧ³ðÈÙÁÁ½ÌÊÚ¼ÓÈëÁ˸ÃÂÛÎIJ¿·ÖÊÂÇé¡£¡£¡£
½üÄêÀ´£¬£¬£¬Ð¤Ê˽ÌÊÚ¿ÎÌâ×éÔÚÖ²Îï×ÔÊɵÄÐÄÀí¹¦Ð§¼°×ÔÊÉÌåÐγɻúÖÆÑо¿ÖÐÈ¡µÃÁËϵÁÐÑо¿Ð§¹û£¬£¬£¬·¢Ã÷ÁË×ÔÊÉͨ¹ýµ÷¿ØË®ÑîËá½éµ¼µÄ»îÐÔÑõƽºâ£¬£¬£¬¼ÓÈëÖ²ÎïµÍÑõÓ¦´ðµÄй¦Ð§£¨Chen et al., Autophagy, 2015£©£»Õ¹ÏÖÁË×ÔÊÉͨ¹ýµ÷¿Ø¹ýÑõ»¯ÎïøÌåÎȹÌÐÔ¼°»îÐÔÑõÎÈ̬£¬£¬£¬¼ÓÈëµ÷¿ØÆÏÌÑÌÇÐźÅÓ¦´ðºÍÖ²Îï¸ù·ÖÉú×éÖ¯»îÐԵķÖ×Ó»úÀí£¨Huang et al., Autophagy, 2019£©£»ÆÊÎöÁËTRAF1ÌÖÂÛ·Ö×ÓÂѰ׽鵼SINATs¶ÔATG6ºÍATG13ÂѰ׵ķºËØ»¯ºÍÎȹÌÐÔ£¬£¬£¬¶¯Ì¬µ÷¿ØÖ²Îï×ÔÊÉÌåÐγɵÄлúÖÆ£¨Qi et al., Plant Cell 2017; Qi et al., Plant Cell, 2020£©£»ÆÊÎöÁËÖ²Îï×ÔÊÉ¡¢¡¢¡¢ÂѰ×øÌåºÍÒºÅÝ·ÖÑ¡µÈÂѰ×ÖÊÖÊÁ¿¿ØÖÆÍ¨Â·»¥×÷£¬£¬£¬Í¨¹ýÓ°ÏìÒªº¦ÂѰ×FREE1ºÍVPS23aÎȹÌÐÔ£¬£¬£¬Ï¸Äåµ÷¿ØÍÑÂäËáÐźÅתµ¼µÄ·Ö×Ó»úÀí£¨Xia et al., Plant Cell, 2020£©¡£¡£¡£ÕâЩÑо¿Ð§¹ûΪÉîÈëÃ÷È·Ö²Îï×ÔÊɵÄÉúÎïѧ¹¦Ð§¼°Æäµ÷¿Ø»úÀíÌṩÁËÐÂÖ¤¾ÝºÍÐÂÊӽǣ¬£¬£¬»ñµÃÁ˹ú¼ÊÙÉÐеĹØ×¢ºÍÈϿɣ¬£¬£¬¶àƪÂÛÎÄ»ñÑ¡ÖØµãÍÆ¼ö»òESI¸ß±»ÒýÂÛÎÄ¡£¡£¡£
ÂÛÎÄÁ´½Ó£ºhttps://pubmed.ncbi.nlm.nih.gov/36053201/