ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶£¨Í¨Ñ¶Ô±³²êÍ£©ÒÔË«Á´DNAΪ°ÐµãµÄ˳²¬ÊÇÁÙ´²ÆÕ±éʹÓõĿ¹Ö×ÁöÒ©Î˳²¬ÄÍÒ©ÒѳÉΪ°©Ö¢ÖÎÁƵÄÒ»ºÆ½ÙÌ⣬¿ª·¢·ÇË«Á´DNAΪ°ÐµãµÄÐÂÐͲ¬À࿹Ö×ÁöÒ©ÎïÔÚսʤÖ×ÁöÄÍÒ©¡¢¡¢¡¢ÊµÏÖ¾«×¼ÖÎÁÆÖоßÓÐÁÉÀ«µÄÓ¦ÓÃÔ¶¾°¡£
¶ËÁ£ÊDZ£´æÓÚȾɫÌå×îºóµÄһС¶ÎDNA¨CÂѰ×Öʸ´ºÏÌ壬Óëϸ°ûÐàÂõÇ×½üÏà¹Ø¡£¶ËÁ£DNA¸»º¬ÄñàÑßʼî»ù£¨G£©£¬ÔÚÌØ¶¨Ìõ¼þ¿É±»ÓÕµ¼ÐγÉG¨CËÄÁ´Ì壬×èÖ¹¶ËÁ£Ã¸Ê¶±ð¶ËÁ£ÐòÁУ¬ÓÕµ¼¶ËÁ£¹¦Ð§ÔÓÂÒ£¬³ÉΪÖ÷ÒªµÄ¿¹Ö×Áö°Ðµã¡£Òѱ¨µÀµÄ¶ËÁ£G¨CËÄÁ´ÌåÎȹ̼ÁÑо¿¼¯ÖÐÓÚ·ÇÐÄÀíµÄÏ¡ÊÍÌõ¼þ£¬ÓÉÓÚϸ°ûºËÖгäÂúÁ˶àÖÖÉúÎï·Ö×Ó£¨×ÜŨ¶È¸ß´ï400 mg/mL£©£¬·ÇÐÄÀíµÄÏ¡ÊÍÌõ¼þÎÞ·¨ÕæÊµµØÄ£ÄâÕâÒ»ÉúÎï·Ö×ÓÓµ¼·ÇéÐΡ£ÏÖÓÐÑо¿Åú×¢£¬·Ö×ÓÓµ¼·ÇéÐζԶËÁ£G¨CËÄÁ´Ìå¹¹ÏóºÍÎȹÌÐÔÓÐÏÔ×ÅÓ°Ï죬ÈçÉÌÓÃG¨CËÄÁ´ÌåÎȹ̼ÁTMPyP4ÔÚ·Ö×ÓÓµ¼·Ìõ¼þÖÐËðʧÎȹÌG¨CËÄÁ´ÌåÒÔ¼°ÓÕµ¼¶ËÁ£¹¦Ð§ÔÓÂÒµÄÄÜÁ¦¡£

ͼ1. ÊÖÐÔîÉ-²¬Ë«ºËÅäºÏÎïÓÕµ¼Ë³²¬ÄÍÒ©Ö×Áöϸ°û¶ËÁ£¹¦Ð§ÔÓÂÒµÄ×÷ÓûúÀíʾÒâͼ
ngµç×ÓÓÎÏ·»¯Ñ§Ñ§Ôº³²êͽÌÊÚ¿ÎÌâ×éºã¾ÃÖÂÁ¦ÓÚ½ðÊôÅäºÏÎÖ×ÁöÑо¿£¬Í¨¹ý½ðÊôÅäºÏÎïµÄ½á¹¹ÐÞÊκ͹âÎïÀíÐÔ×Óµ÷¿Ø£¬ÊµÏÖÁ˶ÔÖ×Áöϸ°ûÄÚϸ°ûÆ÷µÄ°ÐÏò¸»¼¯ºÍÒªº¦ÂѰ׵ÄÑõ»¯ËðÉË£¬·¢Ã÷¶à¸öÄÜÓÐÓÃսʤÖ×ÁöÄÍÒ©ºÍÓÕµ¼ÃâÒßÔÐÔϸ°ûéæÃüµÄ·Ö×ÓÕïÁÆÊÔ¼Á¡££¨Nat. Chem., 2019, 11, 1041; Nat. Commun., 2020, 11, 3262; J. Am. Chem. Soc., 2022, 144, 4091; Angew. Chem. Int. Ed., 2015, 54, 14049; Angew. Chem. Int. Ed., 2017, 56, 14898; Angew. Chem. Int. Ed., 2019, 58, 14334; Angew. Chem. Int. Ed., 2020, 59, 3315; Angew. Chem. Int. Ed., 2020, 59, 20697; Angew. Chem. Int. Ed., 2021, 60, 4657; Angew. Chem. Int. Ed., 2022, 61, e202205429; Adv. Mater., 2022, 34, 2100245; PNAS, 2018, 115, 5664; PNAS, 2019, 116, 20296£©¡£
¿ËÈÕ£¬¿ÎÌâ×éÉè¼ÆºÏ³ÉÁ˲¬ÅäºÏÎPt£©¡¢¡¢¡¢ÊÖÐÔîÉÅäºÏÎ¦¤-Ru£¬¦«-Ru£©ÒÔ¼°ÊÖÐÔîÉ-²¬Ë«ºËÅäºÏÎ¦¤-RuPt£¬¦«-RuPt£©¡£¸ÃϵÁÐÅäºÏÎï¶ÔÈ˶ËÁ£DNAÐòÁоßÓиßÑ¡ÔñÐÔ£¬ÔÚ·ÇÐÄÀíµÄÏ¡ÈÜÒºÌõ¼þÖоù¿É¸ßЧÓÕµ¼²¢Îȹ̶ËÁ£G¨CËÄÁ´Ì壻£»µ«ÔÚ·Ö×ÓÓµ¼·Ìõ¼þÏ£¬½öÓÐË«ºËÅäºÏÎ捻-RuPtºÍ¦«-RuPt±£´æÎȹ̶ËÁ£G¨CËÄÁ´ÌåÄÜÁ¦¡£·Ö×Ó¶Ô½ÓÄ£Äâ֤ʵ·Ö×ÓÓµ¼·Ìõ¼þÏ£¬¦¤-RuPtºÍ¦«-RuPtͨ¹ý¾²µç×÷ÓÃÓë¶ËÁ£G¨CËÄÁ´ÌåÁ¬Ïµ¡£Ê¹ÓÃÉúÎïËØ±ê¼ÇµÄDNA Cage¸ºÔئ¤-RuPtºÍ¦«-RuPt£¬ÊµÏÖÖ×Áöϸ°û°ÐÏòÐÔ¼°Ï¸°ûºË¸»¼¯¡£¾ÓÉ2Ìì1´Îβ²¿¾²Âö×¢Éä¸øÒ©£¬Á¬Ðø16ÌìµÄÖÎÁƺ󣬦¤-RuPt@biotin-DNA cageºÍ¦«-RuPt@biotin-DNA cageÔÚÂãÊóÄÍÒ©Ö×ÁöÄ£×ÓÖÐÌåÏÖ³öÁ˺ÜÊÇÓÅÒìµÄ¿¹Ö×Áö»îÐÔ¡£
Ïà¹ØÐ§¹ûÒÔ¡°Chiral RuII-PtII Complexes Inducing Telomere Dysfunction against Cisplatin-Resistant Cancer Cells¡±ÎªÌ⣬½ÒÏþÔÚAngewandte Chemie International Edition£¬ngµç×ÓÓÎÏ·ÐÜ¿²©Ê¿ºÍÅ·Ñô³Ë²©Ê¿Îª¸ÃÎÄÕµÄÅäºÏµÚÒ»×÷Õߣ¬³ÂÓí¸±½ÌÊÚ£¨ngµç×ÓÓÎÏ·£©¡¢¡¢¡¢Íò¼á½ÌÊÚ£¨»ªÖÐʦ·¶´óѧ£©¡¢¡¢¡¢³²êͽÌÊÚ£¨ngµç×ÓÓÎÏ·£©ÎªÅäºÏͨѶ×÷Õß¡£
¸ÃÊÂÇé»ñµÃ¹ú¼Ò×ÔÈ»¿ÆÑ§»ù½ð¡¢¡¢¡¢ºþÄÏÊ¡¿Æ¼¼Á¢ÒìÍýÏë¡¢¡¢¡¢ÉúÎïÎÞ»úÓëºÏ³É»¯Ñ§½ÌÓý²¿ÖصãʵÑéÊҺ͹㶫ʡÏû»¯ÏµÍ³¶ñÐÔÖ×Áö·ÀÖÎÑо¿ÖصãʵÑéÊҵĴóÁ¦Ö§³Ö¡£
ÂÛÎÄÁ´½Ó£º£ºhttps://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202204866