ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶£¨Í¨Ñ¶Ô±ÐÜÐ¥ÁÖ£©ÃâÒßÔ´ÐÔϸ°ûéæÃü£¨immunogenic cell death, ICD£©ÊÇÖ¸Ö×Áöϸ°ûÔÚÍâ½ç´Ì¼¤µÄ×÷ÓÃϽ鵼»úÌ屬·¢¿¹Ö×ÁöÃâÒßÏìÓ¦µÄÀú³Ì£¬£¬×îÔçÓÉGuido Kroemer¿ÎÌâ×éÔÚÑо¿Ýì»·À໯ÁÆÒ©Îï¶àÈá±ÈÐÇ´¦ÀíµÄϸ°ûÖз¢Ã÷¡£¡£¡£ÏÖÔÚ£¬£¬ÒÑÓаüÀ¨Ã×ÍÐÝìõ«¡¢¡¢°ÂɳÀû²¬µÈÁÙ´²Ê¹ÓõϝÁÆÒ©Îï±»·¢Ã÷¾ßÓÐICD»îÐÔ¡£¡£¡£ÓÉÓÚ¼æ¾ß¿¹Ö×Áöϸ°û¶¾ÐÔÓ뼤»î¿¹°©ÃâÒßµÄÄÜÁ¦£¬£¬ICDÒ©ÎïÕ¹ÏÖ³öÁ˸üºÃÁÙ´²Ó¦ÓÃÔ¶¾°¡£¡£¡£È»¶ø£¬£¬ICDÒ©Î↑·¢ÈÔÈ»ÃæÁÙÒÔϼ¸¸ö×è°£º£º£º£¨1£©¾ßÓÐICD»îÐԵĿ¹°©Ð¡·Ö×ÓÈÔÈ»½ÏÉÙ£»£»£¨2£©Ä¿½ñ¹ØÓÚICDÕ÷ÏóµÄ·Ö×Ó»úÀíÉв»Ã÷È·¡£¡£¡£
¿ËÈÕ£¬£¬ngµç×ÓÓÎϷҩѧԺ×ÞÌÏÌϽÌÊÚ¿ÎÌâ×éÓë¹ãÎ÷ʦ·¶´óѧÁººê½ÌÊÚ¿ÎÌâ×éÏàÖú£¬£¬Æ¾Ö¤ICDÓëÄÚÖÊÍøÓ¦¼¤µÄ½ÏÇ¿ÁªÏµ£¬£¬¾ò¿ÍÁ˳öÒ»¸ö»ùÓÚÈý¼ÛÒ¿µÄ¿¹°©½ðÊôÅäºÏÎ1a£©¾ßÓÐÓÅÒìµÄICD»îÐÔ¡£¡£¡£Ëæºó£¬£¬¶Ô¸Ã»¯ºÏÎïµÄË«µªÔÓ»·¿¨±öÅäÌå¾ÙÐÐÐÞÊΣ¬£¬ÒýÈëÁ˹âÇ׺ͱêÇ©Óëµþµª»ùÍÅ£¬£¬»ñµÃÁË¿ÉÓÃÓÚ»¯Ñ§ÂѰ×ÖÊ×éѧÑо¿µÄ̽Õë·Ö×Ó¡£¡£¡£¿£¿ÎÌâ×é½ø¶øÊ¹ÓøÃ̽ÕëץȡÁËһϵÁÐÂѰ×Öʰбꡣ¡£¡£

ͼ1. »¯Ñ§ÂѰ×ÖÊ×éѧչÏÖ½ðÊôÒ¿ÅäºÏÎïµÄ°ÐÂѰ×BiP
»ùÓÚÆäËüICDÏà¹ØÑо¿µÄÏßË÷£¬£¬ÍŶӳÉÔ±Ëø¶¨ÁËER stressµÄ½¹µãµ÷¿ØÂѰ×GRP78/BiP×÷ΪÑо¿¹¤¾ß£¬£¬Í¨¹ýһϵÁÐʵÑéÑéÖ¤ÁË1a¿ÉÒÔͨ¹ý½µµÍBiPÂѰ׵ÄÎȹÌÐÔ½ø¶øÒÖÖÆÆä»îÐÔ¡£¡£¡£¸üÓÐȤµÄÊÇ£¬£¬ÒÑÖªµÄICDÒ©ÎïÈçÃ×ÍÐÝìõ«¡¢¡¢°ÂɳÀû²¬µÈ¾ù¿É×÷ÓÃÓÚBiP£¬£¬Ô¤Ê¾ÁËÒÖÖÆ¸ÃÂѰ×ÔÚ¼¤»îICDÖеÄÖ÷Òª×÷Óᣡ£¡£×îºó¾ÓÉÉúÎïÐÅϢѧÆÊÎö·¢Ã÷BiPÔÚÈý·ÖÖ®Ò»ÒÔÉϵÄÖ×ÁöÀàÐÍÖи߱í´ï£¬£¬¾ßÓп¹Ö×Áö°ÐµãDZÁ¦¡£¡£¡£×ÛÉÏ£¬£¬±¾Ñо¿¿ªÕ¹ÁËÒ»¸öеÄICD·Ö×Ó²¢»ùÓÚ»¯Ñ§ÂѰ×ÖÊ×éѧµÈÊÖÒÕ·¢Ã÷ÁËBiPÂѰ×ÔÚICDÖеÄ×÷Óᣡ£¡£

ͼ2. ¶àÖÖICD¼¤»î·Ö×Ó¿ÉÒÔÒÖÖÆBiP»îÐÔ
¸ÃÑо¿Ð§¹û¿ËÈÕÒÔArticleÐÎʽ½ÒÏþÔÚJ. Am. Chem. Soc.ÉÏ£¬£¬ngµç×ÓÓÎϷΪµÚÒ»µ¥Î»£»£»ngµç×ÓÓÎϷҩѧԺ²©Ê¿ºóÐÜÐ¥ÁÖ¡¢¡¢¹ãÎ÷ʦ·¶´óѧ¸±½ÌÊڻƿ˱óÒÔ¼°ngµç×ÓÓÎϷҩѧԺ2019¼¶×¨ÒµË¶Ê¿Íõ԰ΪÂÛÎĵÄÅäºÏµÚÒ»×÷Õߣ»£»ngµç×ÓÓÎϷҩѧԺ×ÞÌÏÌϽÌÊÚÓë¹ãÎ÷ʦ·¶´óѧÁººê½ÌÊÚΪÅäºÏͨѶ×÷Õß¡£¡£¡£¸ÃÊÂÇé»ñµÃ¹ú¼Ò×ÔÈ»¿ÆÑ§»ù½ðÓÅÒìÇàÄê»ù½ðÏîÄ¿¡¢¡¢¹ú¼Ò×ÔÈ»¿ÆÑ§»ù½ðÇàÄê¿ÆÑ§»ù½ðÏîÄ¿¡¢¡¢Öйú²©Ê¿ºóÃæÉÏÏîÄ¿¡¢¡¢¹ã¶«Ê¡ÊÖÐÔ·Ö×ÓÓëÒ©Îï·¢Ã÷ÖØµãʵÑéÊÒ¡¢¡¢¹ã¶«Ê¡Öé½È˲ÅÍýÏëÇàÄê°Î¼âÈ˲𢡢¹ã¶«Ê¡×ÔÈ»¿ÆÑ§»ù½ð¡¢¡¢¹ãÖÝÊпƼ¼ÍýÏëµÈÏîĿ֧³Ö¡£¡£¡£
ÂÛÎÄÁ´½Ó£º£º£ºhttps://pubs.acs.org/doi/10.1021/jacs.2c02435