ngµç×ÓÓÎÏ·

05

¿ÆÑÐÏ£Íû

³ÂÐ¡Êæ¡¢¡¢¡¢ÑÈÙ¡¢¡¢¡¢Ìï¹ú±¦ÏàÖúÍŶÓÔÚ¿¹ÉúËØÄÍÒ©½ø»¯ÁìÓòÈ¡µÃÏ£Íû

¸å¼þȪԴ£ºÖÐɽҽѧԺ ±à¼­£ºÖ£Áú·É¡¢¡¢¡¢Íõ¶¬Ã· ÉóºË£ºÏÄçø ÔĶÁÁ¿£º

ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶£¨Í¨Ñ¶Ô±Ìï¹ú±¦£©¿¹ÉúËØµÄ·¢Ã÷ÊÇ20ÊÀ¼ÍҽѧʷÉÏ×îѤÀõijɼ¨Ö®Ò»¡£¡£¡£¡£¡£È»¶ø£¬£¬Ëæ×Å¿¹ÉúËØ´ó×ÚºÍÎÞÐòʹÓ㬣¬¿¹ÉúËØÄÍÒ©ÎÊÌâÔòÒѳÉΪ21ÊÀ¼ÍÈËÀ಻µÃ²»ÃæÁÙµÄÑÏËàÌôÕ½¡£¡£¡£¡£¡£¿£¿¹ÉúËØÄÍÒ©ÎÊÌâ²»µ«ÊÇÀ§ÈÅÁÙ´²µÄÒ»ºÆ½ÙÌ⣬£¬¡°³¬µÈÄÍҩϸ¾ú¡±µÄÒ»Ö±·ºÆð¸üÊÇÒýÆð¹«Öڵļ«´ó¿Ö»Å£¬£¬³ÉΪȫÇòÆÕ±é¹Ø×¢µÄ¹«¹²ÉúÎïÇå¾²ÎÊÌâ¡£¡£¡£¡£¡£´ÓÒÅ´«Ñ§½Ç¶È£¬£¬ÄÍÒ©ÐԵı¬·¢ÊÇϸ¾úΪӦ¶ÔÇéÐÎת±ä£¬£¬ÓÈÆäÊÇ¿¹ÉúËØÑ¡ÔñѹÁ¦Ï½ø»¯µÄ²úÆ·¡£¡£¡£¡£¡£ÔÚ½ø»¯Àú³ÌÖУ¬£¬¿¹ÉúËØÄÍÒ©»ùÒòµÄÿ¸öºËÜÕËáλµã¶¼¿ÉÄܱ¬·¢Í»±ä£¬£¬ÓÐЩͻ±äʹϸ¾ú·´¿¹ÉúËØ¸üÃô¸Ð£¬£¬ÓÐЩ»áµ¼Ö¸üÄÍÒ©¡£¡£¡£¡£¡£ÔÚ¿¹ÉúËØÑ¡ÔñѹÁ¦Ï£¬£¬¸üÄÍÒ©µÄÍ»±äÀàÐÍ»á¸üÈÝÒ×±»É¸Ñ¡³öÀ´£¬£¬²¢ÒýÆðÖð²½À©É¢ºÍÈö²¥¡£¡£¡£¡£¡£

2022Äê4ÔÂ29ÈÕ£¬£¬ngµç×ÓÓÎÏ·ÖÐɽҽѧԺ³ÂÐ¡Êæ½ÌÊÚ¡¢¡¢¡¢ÑÈÙ½ÌÊÚºÍÌï¹ú±¦½ÌÊÚÏàÖúÑо¿ÍŶÓÔÚMolecular Biology and EvolutionÔÚÏß½ÒÏþÌâΪ¡°Prediction of Antibiotic Resistance Evolution by Growth Measurement of All Proximal Mutants of Beta-Lactamase¡±µÄÑо¿ÂÛÎÄ¡£¡£¡£¡£¡£¸ÃÊÂÇéÒÔÁÙ´²ÆÕ±éÊ¢Ðеij¬¹ãÆ×¦Â-ÄÚõ£°·Ã¸ÄÍÒ©»ùÒòblaCTX-MΪÑо¿Ä£×Ó£¬£¬¹¹½¨Á˰üÀ¨blaCTX-MËùÓе¥µãÍ»±ä»ùÒòÐ͵Ĵ󳦸˾ú¿Ë¡ÎĿ⣬£¬Á¬Ïµ¸ßͨÁ¿²âÐòºÍÉñ¾­ÍøÂçÄ£×ÓʵÏÖÁ˶ÔÄÍÒ©»ùÒò½ø»¯µÄËÝÔ´ºÍǰհÐÔÔ¤²â¡£¡£¡£¡£¡£

Ñо¿ÍŶÓʹÓûìÔÓÒýÎï¡¢¡¢¡¢ÒÔFusion PCRµÄÒªÁìÔÚÄÍÒ©»ùÒòÖÐÒýÈëÍ»±ä£¬£¬¹¹½¨°üÀ¨ËùÓе¥¼î»ùÍ»±äµÄµÈλ»ùÒò¿â£¬£¬Í¬Ê±Ã¿¸ö»ùÒòÐ;ù´øÓÐËæ»úµÄÌõÐÎÂë¡£¡£¡£¡£¡£ÎªÁËÈ·±£Í»±ä»ùÒòÐÍÔÚÿ¸öϸ°ûÖп½±´ÊýÒ»Ö£¬£¬×÷Õß½¨ÉèÁËÒ»Ì׸ßЧµÄÕûºÏϵͳ£¬£¬½«Í»±ä»ùÒòÐÍÕûºÏµ½´ó³¦¸Ë¾úMG1655µÄattHK022λµã£¬£¬×îÖÕ»ñµÃÁ˵Èλ»ùÒòÍ»±äÌå¿â£¬£¬²¢Í¨¹ýÈý´ú²âÐòÊÖÒÕ»ñµÃ»ùÒòÐÍÓëÌõÐÎÂëµÄ¶ÔÓ¦¹ØÏµ¡£¡£¡£¡£¡£Á¬ÏµÒ©ÎïɸѡºÍ¶þ´ú²âÐòÊÖÒÕ£¬£¬²â¶¨Ã¿¸ö»ùÒòÐÍÔÚ²î±ðÒ©ÎïŨ¶ÈϵÄÏà¶ÔÉú³¤Öµ£¨Relative growth£©£¬£¬²¢»æÖÆÁËÏìÓ¦µÄ˳Ӧ¶È¾°¹Û£¨Fitness landscape£©¡£¡£¡£¡£¡£ÓÐÒâ˼µÄÊÇ£¬£¬²¿·Öλµã£¬£¬ÈçP167¡¢¡¢¡¢L169¡¢¡¢¡¢E166£¬£¬±¬·¢Í»±ä½«ÏÔÖøÌá¸ß¾þ³¦¸Ë¾úµÄÏà¶ÔÉú³¤ÖµºÍMICÖµ£¬£¬¶øÕâЩͻ±äÌåµÄÖ÷Òª¸»¼¯ÔÚ³¬¹ãÆ×¦Â-ÄÚõ£°·Ã¸CTX-MµÄ»îÐÔÖÐÐÄ£¨Í¼1£©¡£¡£¡£¡£¡£

                                           

E8596D46A96F0E147EA2D5283C7_22635166_6F4A5

 

ͼ1. ¿¹ÉúËØÄÍÒ©»ùÒò½ø»¯Ë³Ó¦¶È¾°¹ÛµÄ½¨Éè


Ñо¿ÍŶӽøÒ»²½ÒÔ˳Ӧ¶È¾°¹ÛΪ»ù´¡£¬£¬»®·Ö½¨ÉèÁËǰհÐÔÔ¤²âÄ£×Ó£¨PEARP£©ºÍ»ØÊ×ÐÔËÝÔ´Ä£×Ó£¨PEARR£©¡£¡£¡£¡£¡£PEARPÄ£×Ó¿ÉÓÃÓÚÔ¤²âеÄÍ»±ä»ùÒòÐÍÊÇ·ñÄÍÒ©£¬£¬ÆäAUCΪ0.928¡£¡£¡£¡£¡£Ä£×ÓÔ¤²âΪÄÍÒ©µÄ»ùÒòÐÍ£¨°üÀ¨µ¥µã¡¢¡¢¡¢Ë«µã¡¢¡¢¡¢Èýµã¡¢¡¢¡¢ËĵãÍ»±ä»ùÒòÐÍ£©ÏÔÖø¸»¼¯ÓÚÁÙ´²ÊèÉ¢µ½µÄ»ùÒòÐÍ¡£¡£¡£¡£¡£PEARRÄ£×Ó¿ÉÓÃÓÚ»ØÊ×ÐÔÔ¤²âÄÍÒ©»ùÒòµÄ½ø»¯¹ì¼££¬£¬ÇÒÆäÔ¤²âµÄ½ø»¯¹ì¼£ÔÚSSWM£¨Strong-Selection-Weak-Mutation£©Ä£×ÓÏÂÓë×ÔÁ¦µÄÒ©ÃôʵÑéµÄЧ¹ûÏà·û£¨Í¼2£©¡£¡£¡£¡£¡£

9D67D86CE0BE6740AF21229B7E5_5A960CEE_43CD3


ͼ2£º¿¹ÉúËØÄÍÒ©»ùÒò½ø»¯µÄ»ØÊ×ÐÔËÝÔ´ºÍǰհÐÔÔ¤²âÄ£×Ó


×ÛÉÏËùÊö£¬£¬Ñо¿ÍŶӿª·¢µÄ¸ßͨÁ¿Æ½Ì¨¿ÉÓÃÓÚ¾«×¼Ô¤²â¿¹ÉúËØÄÍÒ©»ùÒòµÄ½ø»¯¹ì¼£¡£¡£¡¢¡¢¡¢¸¨Öú¿¹¾úÒ©ÎïÉè¼ÆºÍÖ¸µ¼Ò©ÎïʹÓ㬣¬ÎªÁÙ´²¿¹ÉúËØÄÍÒ©ÐÔ·À¿ØÌṩÓÐÁ¦Ö§³Ö¡£¡£¡£¡£¡£

ngµç×ÓÓÎÏ·ÖÐɽҽѧԺ¸±Ñо¿Ô±·ë˼Դ¡¢¡¢¡¢²©Ê¿Ñо¿ÉúÎâ׿ÐÒ¡¢¡¢¡¢ÁºÍñ·ÆÎªÂÛÎÄÅäºÏµÚÒ»×÷Õߣ¬£¬³ÂÐ¡Êæ½ÌÊÚ¡¢¡¢¡¢ÑÈÙ½ÌÊÚºÍÌï¹ú±¦½ÌÊÚΪÂÛÎÄͨѶ×÷Õß¡£¡£¡£¡£¡£

ÂÛÎÄÁ´½Ó£ºhttps://doi.org/10.1093/molbev/msac086


¡¾ÍøÕ¾µØÍ¼¡¿