ngµç×ÓÓÎÏ·

05

¿ÆÑÐÏ£Íû

ngµç×ÓÓÎÏ·Ö×Áö·ÀÖÎÖÐÐÄÖìТ·å½ÌÊÚÍŶӷ¢Ã÷µ÷¿ØÉñ¾­Ä¸Ï¸°ûÁö·Ö»¯µÄÖ÷Òª»úÖÆºÍабê

ÔĶÁÁ¿£º£º£º

10ÔÂ27ÈÕ£¬£¬ngµç×ÓÓÎÏ·Áö·ÀÖÎÖÐÐÄÖìТ·å½ÌÊÚÍŶÓÔÚ¡¶Nature Communications¡·ÔÓÖ¾ÉϽÒÏþÌâΪ¡°CaMKII-mediated Beclin 1 phosphorylation regulates autophagy that promotes degradation of Id and neuroblastoma cell differentiation¡±£¨ÎÄÕÂÁ´½Ó£º£º£ºhttps://www.nature.com/articles/s41467-017-01272-2£©µÄÑо¿ÂÛÎÄ£¬£¬Õ¹ÏÖÁ˸Ƶ÷ÂѰ׼¤Ã¸CaMKII½éµ¼Beclin 1Á×Ëữ½øÒ»²½Ôö½øÆä±¬·¢K63ÐÍ·ºËØ»¯²¢¼¤»î×ÔÊÉ£¬£¬´Ó¶ø¼ÓËÙ·Ö»¯ÒÖÖÆÂѰ×Id1ºÍId2µÄ½µ½â£¬£¬µ¼ÖÂÉñ¾­Ä¸Ï¸°ûÁö·Ö»¯¡£

Ê×Ò³|ngµç×ÓÓÎÏ·Öйú¼¯ÍŹٷ½ÍøÕ¾

Éñ¾­Ä¸Ï¸°ûÁöÊǶùͯ×î³£¼ûµÄ­ÍâÖ×Áö£¬£¬Ô¼Õ¼¶ùͯÖ×ÁöµÄ6-10%£¬£¬Õ¼¶ùͯÖ×ÁöéæÃüµÄ15%¡£Éñ¾­Ä¸Ï¸°ûÁö¾ßÓи߶Èδ·Ö»¯µÄÌØÕ÷£¬£¬¹ØÓÚ¸ßΣÐÍ»¼¶ùµÄÖÎÁÆÏ£Íû»ºÂý£¬£¬ÐèҪѰÕÒÔ½·¢ÓÐÓõÄÖÎÁÆÕ½ÂÔ¡£×ÔÊÉÊÇϸ°ûÔÚÎïÖÊÄÜÁ¿È±·¦»òÍâÇéÐÎѹÁ¦Ï£¬£¬ÉúÎï´ó·Ö×Ó»òϸ°ûÆ÷¾­Ë«²ãĤ½á¹¹ÄÒÅݰü¹ü²¢±»´ó×Ú½µ½âµÄÀú³Ì¡£×ÔÊÉÓë¶ñÐÔÖ×Áö±¬·¢¿ªÕ¹µÄ¹ØÏµÊǽüÄêÀ´Ñ§½çËù¹Ø×¢µÄÈÈÃÅÎÊÌâ¡£×ÔÊÉÔÚϸ°û·Ö»¯ÖеÄ×÷ÓÃÏÊΪ±¨µÀ£¬£¬ÖìТ·å½ÌÊÚÑо¿ÍŶӷ¢Ã÷¸Æµ÷ÂѰ׼¤Ã¸CaMKII¿ÉÒÔÖ±½ÓÁ×ËữBeclin 1µÄË¿°±Ëá90λµã£¬£¬²¢Ôö½øºóÕß±¬·¢K63ÐÍ·ºËØ»¯½ø¶ø¼¤»î×ÔÊÉ£¬£¬Í¬Ê±£¬£¬CaMKIIÒ²¿ÉÒÔÁ×Ëữ·Ö»¯ÒÖÖÆÂѰ×Id1ºÍId2£¬£¬Á×ËữµÄIdÂѰ׽ø¶øÓë·ºËØÅþÁ¬Ã¸TRAF6Á¬Ïµ£¬£¬Ôö½øIdÂѰ׵ÄK63ÐÍ·ºËØ»¯£¬£¬·ºËØ»¯µÄId1ºÍId2ͨ¹ýÓë×ÔÊÉÊÜÌåP62µÄÁ¬Ïµ±»´øÈëµ½×ÔÊÉÌåÖнµ½â¡£IdÂѰ׵Ľµ½âÔö½øÁËÉñ¾­Ä¸Ï¸°ûÁöϸ°û·Ö»¯£¬£¬´Ó¶øµÖ´ïÒÖÖÆÖ×ÁöµÄÄ¿µÄ¡£

ÕâÒ»Ñо¿Õ¹ÏÖÁËCaMKII¼¤»îµ½IdÂѰ׵Ä×ÔÊÉÐÔ½µ½â½ø¶øµ÷¿ØÏ¸°û·Ö»¯µÄ·Ö×Ó»úÖÆ£¬£¬ÎªÁÙ´²ÉÏÉñ¾­Ä¸Ï¸°ûÁö°ÐÏòÖÎÁÆÌṩÁËеİбê¡£

¸ÃÑо¿ÊÂÇéµÄµÚÒ»×÷ÕßΪngµç×ÓÓÎÏ·Ö×Áö·ÀÖÎÖÐÐÄÀîÐù²©Ê¿¡¢ÎâÏþçù²©Ê¿¡¢µËÈØ¸±Ñо¿Ô±£¬£¬Í¨Ñ¶×÷ÕßÊÇÖìТ·å½ÌÊÚ¡£¸ÃÏîÄ¿»ñµÃÁ˹ú¼Ò×ÔÈ»¿ÆÑ§»ù½ð¡¢973ÍýÏëÒÔ¼°»ªÄÏÖ×Áöѧ¹ú¼ÒÖØµãʵÑéÊҵȻù½ðºÍµ¥Î»µÄÖ§³Ö¡£

¡¾ÍøÕ¾µØÍ¼¡¿