ÁöÄÚϸ¾úÔÚÖ×Áö±¬·¢ºÍתÒÆÖеÄ×÷ÓÃÈÕ½¥Êܵ½ÖØÊÓ¡£¡£¡£¾ßºËËó¸Ë¾ú£¨F. nucleatum£©ÊÇÒ»ÖÖ¸ïÀ¼ÊÏÒõÐÔÎÞÑ¿°ûרÐÔÑáÑõ¾ú£¬£¬£¬¸Ãϸ¾úÔÚ½áÖ±³¦°©£¨colorectal cancer, CRC£©»¼ÕßµÄÖ×Áö×éÖ¯ºÍ·à±ãÑù±¾Öи»¼¯£¬£¬£¬Òѱ»Ö¤ÊµÊÇ´ÙÖ±³¦°©¿ªÕ¹µÄDZÔÚÖ÷ҪΣÏÕÒòËØ¡£¡£¡£Ò©Ñ§ÔºÕŸï½ÌÊÚÍŶÓÇ°ÆÚÑо¿·¢Ã÷¸Ã¾úÊǼæÐÔ°ûÄÚ¾ú£¬£¬£¬ÄÜÔÚ¾ÞÊÉϸ°ûÖдæ»î²¢ÔöÖ³£¬£¬£¬ÊÇÊ׸ö±»±¨µÀµÄÑÏ¿áÑáÑõµÄ°ûÄÚ¾ú£¬£¬£¬¿ªÍØÁËÑÏ¿áÑáÑõ¾úËÞÖ÷ϸ°ûÄÚ´æ»îÑо¿µÄÐÂÁìÓò¡£¡£¡£
°ûÄÚ¾úѬȾ¿ÉÒԽ鵼ËÞÖ÷ϸ°ûÉø͸ÐÔÍâÃÚÌ壨exosome£©µÄ¸Ä±ä£¬£¬£¬ÍâÃÚÌåͨ¹ýÆäЯ´øµÄÂÑ°×ÖÊ¡¢¡¢¡¢ºËËá¡¢¡¢¡¢Ö¬ÖʺʹúлÎïµÈʩչϸ°û¼äͨѶ¹¦Ð§£¬£¬£¬¼ÓÈë¶àÖÖÐÄÀíºÍ²¡ÀíÀú³Ì¡£¡£¡£½üÄêÀ´£¬£¬£¬Ö×Áöϸ°ûÉø͸µÄÍâÃÚÌåÔÚ°©Ö¢ÖеÄ×÷Óñ»Ã÷È·Ï¢ÕùÎö£¬£¬£¬ÁöÄÚϸ¾úѬȾÐÔÍâÃÚÌåµÄÉø͸¼°Æä¶ÔÖ×ÁöµÄ×÷ÓÃÕÕ¾ÉÒ»ÐÂÁìÓò¡£¡£¡£
¿ËÈÕ£¬£¬£¬ngµç×ÓÓÎϷҩѧԺÕŸï½ÌÊÚÍŶÓÔھߺËËó¸Ë¾ú´Ù½áÖ±³¦°©×ªÒÆ»úÖƵÄÑо¿ÖÐÈ¡µÃÐÂÏ£Íû£¬£¬£¬¸ÃÏîÑо¿Í¨¹ý¶à×éѧÊÖÒÕÊֶη¢Ã÷£º£º¾ßºËËó¸Ë¾úѬȾCRCϸ°ûºó£¬£¬£¬ÓÕµ¼ËÞÖ÷ϸ°ûºó´ó×Ú±¬·¢miR-1246/92b-3p/27a-3pºÍCXCL16/RhoA/IL-8¸»¼¯µÄÍâÃÚÌ壬£¬£¬ÕâЩÖ×Áö¼æ¾ßѬȾÌØÒìÐÔµÄÍâÃÚÌ屻ת´ïµ½Î¢ÇéÐÎÖÐδѬȾµÄCRCϸ°ûÖУ¬£¬£¬Í¨¹ýmiRNAºÍÂѰ׶à¸ö°Ð·Ö×ӺͶà¸ö×÷ÓÃģʽÅäºÏ´Ó¶øÔö½øÁËÈ´Ö±³¦°©µÄתÒÆ¡£¡£¡£ÉÏÊöÑо¿¿ªÍØÁËÁöÄÚѬȾÐÔϸ°ûÌØÒìÐÔÍâÃÚÌåÕâÒ»ÐÂÁìÓòµÄÑо¿£¬£¬£¬ÎªÉîÈëÆÊÎöÖ°©ÐÔϸ¾ú-ËÞÖ÷Ï໥×÷Ó÷Ö×Ó»úÖÆÌṩÁËеĿ´·¨£¬£¬£¬ÌáÐÑÁ˾ߺËËó¸Ë¾úѬȾCRCϸ°ûȪԴµÄÍâÃÚÌå¿ÉÄÜÊÇÒ»ÖÖÖ÷ÒªµÄÖ°©ÒòËØÔö½øCRCµÄ¿ªÕ¹ºÍתÒÆ,²¢Ö¸³öÖ×ÁöÖÎÁÆÖÐÁöÄھߺËËó¸Ë¾úɨ³ýµÄÖ÷ÒªÐÔ£¬£¬£¬ÎªÁÙ´²½áÖ±³¦°©ÖÎÁÆÌṩÁËÓмÛÖµµÄ˼Ð÷¡£¡£¡£
ͼ1£º£º¾ßºËËó¸Ë¾úѬȾÐÔÍâÃÚÌå´ÙÖ×ÁöתÒÆģʽͼ£¨A schematic model of Fn-Ex functions in tumour metastasis£©
´ËÏîÑо¿Ð§¹û½üÆÚÒÔArticleÐÎʽÔÚÏß½ÒÏþÓÚ¹ú¼ÊÖøÃûѧÊõÆÚ¿¯Gut£¨IF=19.82£©ÉÏ£¬£¬£¬ÌâΪ¡°Exosomes derived from Fusobacterium nucleatum-infected colorectal cancer cells facilitate tumor metastasis by selectively carrying miR-1246/92b-3p/27a-3p and CXCL16¡±£¨doi.org/10.1136/gutjnl-2020-321187£©¡£¡£¡£
ngµç×ÓÓÎϷҩѧԺ²©Ê¿Éú¹ùËɺ×ΪµÚÒ»×÷Õߣ¬£¬£¬Ë¶Ê¿Éú³Â¿¡¡¢¡¢¡¢³Â·¼·¼ÎªµÚ¶þºÍµÚÈý×÷Õߣ¬£¬£¬ÕŸï½ÌÊÚΪͨѶ×÷Õß¡£¡£¡£±¾Ñо¿»ñµÃÁ˹ú¼Ò×ÔÈ»¿Æѧ»ù½ðµÄÖ§³Ö¼°ngµç×ÓÓÎÏ·Ö×Áö·ÀÖÎÖÐÐÄÁõÍòÀï½ÌÊÚ¿ÎÌâ×éµÄ×ÊÖú¡£¡£¡£
ÂÛÎÄÁ´½Ó£º£ºhttps://gut.bmj.com/content/early/2020/11/10/gutjnl-2020-321187
µØµã:¹ãÖÝÊÐиÛÎ÷·135ºÅ Óʱà:510275
µç»°: 020-84112828
ngµç×ÓÓÎÏ·°æȨËùÓÐ COPYRIGHT?1999-2022 , SUN YAT-SEN UNIVERSITY