ÖÚËùÖÜÖª£¬£¬DNAÊÇÖü´æºÍת´ïÒÅ´«ÐÅÏ¢µÄ³¡ºÏ£¬£¬ÊÇÐí¶à¼²²¡µÄÖ÷ÒªÒ©Îï°Ðµã¡£¡£¡£ÆäÖи»º¬ÄñàÑßʵĹѺËÜÕËá¿ÉÒÔ×Ô×é×°ÐγÉÁ½²ã»ò¶à²ãµÄµÄG-ËÄÁ´Ìå½á¹¹¡£¡£¡£G-ËÄÁ´ÌåDNA¿ÉÒÔÔÚÌØ¶¨µÄϸ°ûÇéÐκÍϸ°ûÖÜÆÚ×Ô×é×°ÐγÉÒÔÖ´ÐÐÌØ¶¨µÄÉúÎïѧÀú³Ì£¬£¬°üÀ¨DNA¸´ÖÆ¡¢¡¢»ùÒò±í´ï¡¢¡¢»ùÒò×éÎȹÌÐԺͶËÁ£ÉúÎïѧµÈ¡£¡£¡£ÎªÁ˽øÒ»²½ÆÊÎöG-ËÄÁ´ÌåDNAµÄ½á¹¹-¹¦Ð§¹ØÏµ¼°ÆäÔÚ°©Ö¢Õï¶ÏºÍÖÎÁÆÖеÄDZÔÚÓ¦Ó㬣¬ÆÈÇÐÐèÒª¿ªÕ¹¶ÔÌåÄÚG-ËÄÁ´ÌåDNAµÄ¿ÉÊӺͶ¨Á¿Ì½²âÒªÁì¡£¡£¡£È»¶øÓÉÓÚG-ËÄÁ´ÌåDNA¾ßÓнṹ¶à̬ÐÔµÈÒòËØ£¬£¬ÊµÊ±¶¨Á¿¼ì²âÌåÄÚG-ËÄÁ´ÌåDNA½á¹¹ÈÔÈ»¾ßÓÐÌôÕ½ÐÔ¡£¡£¡£

¿ËÈÕ£¬£¬ÎÒУ»¯Ñ§Ñ§ÔºÃ«×ÚÍò½ÌÊÚÍŶӱ¨µÀÁËÒ»ÖÖÈý²æÑôÀë×ÓÓ«¹â̽Õ루NBTE£©£¬£¬¸Ã̽Õë¶ÔG-ËÄÁ´Ìå¼°ÆäËûÍØÆË¹¹Ð͵ÄDNA¾ßÓвî±ðµÄÓ«¹âÏìÓ¦£¬£¬ÆäÖÐNBTEÓëG-ËÄÁ´ÌåÁ¬Ïµºó¾ßÓиü¸ßµÄÓ«¹âÁ¿×Ó²úÂʺÍÓ«¹âÊÙÃüÏìÓ¦¡£¡£¡£ÎªÁ˽øÒ»²½Ã÷È·NBTEÓëG-ËÄÁ´ÌåµÄÏ໥×÷Ó÷½Ê½£¬£¬Ñо¿ÍŶÓÓÃNMRµÄÒªÁìÆÊÎöÁËNBTEÓëÁ½ÖÖG-ËÄÁ´ÌåµÄ¸´ºÏÎïÈÜÒº½á¹¹¡£¡£¡£
»ùÓÚ¶ÔNBTEµÄÓ«¹âÊÙÃü³ÉÏñ(FLIM£©µÄ¹â×ÓÊýÆÊÎö£¬£¬Ñо¿ÍŶÓÀÖ³ÉʵÏÖÁ˶¨Á¿Ì½²â»îϸ°ûÖÐG-ËÄÁ´ÌåDNAµÄ°Ù·Öº¬Á¿¡£¡£¡£Ê¹ÓøÃÒªÁìÆÊÎöÁËÈý×鰩ϸ°ûºÍÕý³£Ï¸°ûÖеÄG-ËÄÁ´ÌåDNAµÄ°Ù·Öº¬Á¿£¬£¬·¢Ã÷°©Ï¸°ûÖÐG-ËÄÁ´ÌåDNAº¬Á¿ÊÇÕý³£Ï¸°ûµÄÔ¼Ëı¶£¬£¬ÕâÕ¹ÏÖÁ˸Ã̽ÕëÔÚ°©Ï¸°û¼ì²âÖеÄDZÔÚÓ¦Óᣡ£¡£¸ÄÏîÊÂÇéΪ¿ª·¢×¼È·µÄ̽ÕëÓÃÓÚ̽²â»îϸ°ûÖеÄG-ËÄÁ´Ìå½á¹¹ÌṩÁËÒ»ÖÖеÄÒªÁì¡£¡£¡£
Ñо¿Ð§¹û½üÆÚ½ÒÏþÔÚ»¯Ñ§¶¥¼¶ÆÚ¿¯¡¶µÂ¹úÓ¦Óû¯Ñ§¡·ÉÏ£¬£¬ÎÊÌâΪ¡°Quantitative Detection of G-Quadruplex DNA in Live Cells Based on Photon Counts and Complex Structure Discrimination¡±, Angew. Chem. Int. Ed. 2020, 59 (24), 9719¨C9726¡£¡£¡£ngµç×ÓÓÎÏ·ÔÚ¶Á²©Ê¿Ñо¿ÉúÁõÁøÒ˺ÍÔÚÕ¾²©Ê¿ºóÁõÎÄæÃΪÂÛÎĵĵÚÒ»×÷Õߣ¬£¬Ã«×ÚÍò½ÌÊÚΪͨѶ×÷Õß¡£¡£¡£
ÉÏÊöÑо¿ÊÂÇé»ñµÃÁ˹ú¼Ò×ÔÈ»¿ÆÑ§»ù½ð¡¢¡¢½ÌÓý²¿Á¢ÒìÍŶӡ¢¡¢¹ã¶«Ê¡¿Æ¼¼ÍýÏëÏîÄ¿ºÍÖÐÑë¸ßУ»ù´¡Ñо¿¾·ÑµÈÏîÄ¿µÄ×ÊÖú¡£¡£¡£
ÂÛÎÄÁ´½Ó£º£º£º https://doi.org/10.1002/anie.202002422