ngµç×ÓÓÎÏ·

05

¿ÆÑÐÏ£Íû

»¯Ñ§Ñ§ÔºÀîÀÖ½ÌÊÚÍŶÓÔÚ´ß»¯»Çõ£°·»¯·´Ó³ÉÏÈ¡µÃÖ÷ҪϣÍû

¸å¼þȪԴ£º£º»¯Ñ§Ñ§Ôº ÔĶÁÁ¿£º£º

»Çõ£°·×÷ΪһÖÖÒ½Ò©ºÍũҩÖеÄÖ÷Òª½á¹¹»ùÍÅ£¬ÓÉÓÚÆä¹ãÆ×µÄÉúÎï»îÐÔ£¬Ò»Ö±ÊÇÒ©ÎïÑо¿ÖеÄÒ»¸öÈÈÃÅ¡£Ö»¹Ü¹Å°åµÄ»Çõ£ÂÈ»¯Ñ§ÏÖÔÚÈÔÊÇ×îͨÓõÄÖÆ±¸»Çõ£°·µÄÒªÁì¡£µ«»Çõ£ÂÈÒ×ÓÚË®½â²¢¾ßÓÐÒ»¶¨µÄÑõ»¯ÄÜÁ¦£¬Òò¶ø¶Ô¹ÙÄÜÍŵļæÈÝÐÔÓÐÏÞ£¬ÖÆÔ¼ÁËÆäÔÚÖØ´ó·Ö×ÓºóÆÚ¹ÙÄÜ»¯·½ÃæµÄÓ¦Óá£2014ÄêSharpless½ÌÊÚÌá³öÁËÁò·ú½»Á÷(SuFEx)µÄ¿´·¨£¬Ç¿µ÷ÁËÁò(VI)-·ú»¯Ñ§¼üµÄÎȹÌÐÔ¼°ÆäÔÚÌØ¶¨ÇéÐÎÏÂÌåÏÖ³öµÄ¸ß·´Ó³»îÐÔ¡£ÓÌÈç¡°CuAAcµã»÷»¯Ñ§¡±Ò»Ñù£¬Áò·ú½»Á÷»¯Ñ§ÔÚÒ©Îï·¢Ã÷£¬»¯Ñ§ÉúÎïѧºÍÖÊÁÏ¿ÆÑ§ÖÐÒ²¾ßÓÐÖ÷ÒªµÄ¼ÛÖµ¡£µ«×÷Ϊ´ËÀ໯ѧÖеÄÖ÷Òª³ÉÔ±Ö®Ò»£¬»Çõ£·úºÍ·ú»ÇËáõ¥Óë¼òÆÓ°·ÀàµÄ·´Ó³ÉÐδ»ñµÃÓÐÓõĽâ¾ö¡£Ö®Ç°´ËÀà·´Ó³ÐèÒª½èÖúÓÚµ±Á¿µÄCa(NTf2)2ÊÔ¼ÁÀ´ÊµÏÖ¡£ÓÉÓÚCa(NTf2)2¼ÛÇ®ÌÚ¹ó£¬Òò¶øÄÑÒÔÓ¦ÓÃÓÚ¹æÄ£ÖƱ¸¡£Í¬Ê±¸ÃÒªÁìҲȱ·¦Õë¶ÔµÍ»îÐԵĴóλ×èµ×ÎïµÄÑо¿¡£

Ê×Ò³|ngµç×ÓÓÎÏ·Öйú¼¯ÍŹٷ½ÍøÕ¾

ͼ1 ¾ßÓйãÆ×ÊÊÓÃÐԵĴ߻¯»Çõ£°·»¯·´Ó³

×î½ü£¬ÎÒУ»£»£»¯Ñ§Ñ§ÔºÀîÀÖ½ÌÊÚÍŶӿª·¢ÁËÒ»ÖÖ¾ßÓйãÆ×ÊÊÓÃÐÔµÄË«×é·Ö´ß»¯ÏµÍ³£¬ÔÚ¹èÌí¼Ó¼Á±£´æÏ£¬1-ôÇ»ù±½²¢Èýßò£¨HOBt£©¿ÉÒÔ¸ßЧ´ß»¯»Çõ£·úºÍ·ú»ÇËáõ¥µÄ»Çõ£°·»¯·´Ó³¡£¸ÃÒªÁì·´Ó³´ß»¯¼ÁÓÃÁ¿µÍ£¬µ×Îï¹æÄ£¹ã£¬¹ÙÄÜÍżæÈÝÐԸߣ¬·´Ó³Ìõ¼þÎÂ˳£¬×èÖ¹ÁËÌÚ¹óµÄCa(NTf2)2ÊÔ¼ÁµÄʹÓá£Í¬Ê±£¬¸ÃÒªÁì¹ØÓÚ´óλ×èµÄ»Çõ£·ú»ò°·ÌØÊâÓÐÓ㬹ØÓÚ»îÐԽϵ͵ķҷ¼°·Ò²Í¬ÑùÊÊÓ᣹ØÓÚ¸ü¾ßÌôÕ½ÐԵķú»ÇËáõ¥À໯ºÏÎͬÑù¿ÉÒÔ»ñµÃÁîÈËÖª×ãµÄЧ¹û¡£±ðµÄ£¬¸Ã´ß»¯ÏµÍ³µÄÊÊÓÃÐÔ»¹¿ÉÒÔͨ¹ý·Å´óʵÑéÀ´½øÒ»²½Ö¤Êµ£º£ºÔÚÍò·ÖÖ®¶þµÄ´ß»¯¼ÁÓÃÁ¿Ï£¬½ö½öºÁ¿ËÁ¿µÄ´ß»¯¼Á¾Í¿ÉÒÔ»ñµÃÊýÊ®¿ËµÄ²úÆ·£¬²¢ÇÒ´ËÀú³ÌÎÞÐèÖù²ãÎö´¿»¯¡£

Ê×Ò³|ngµç×ÓÓÎÏ·Öйú¼¯ÍŹٷ½ÍøÕ¾

ͼ2 ¹ÇËèÏËά»¯ÐÂÒ©·Æ×¿ÌæÄᣨFedratinib£©µÄºÏ³Éй¤ÒÕ

ͬʱ£¬¸ÃÒªÁìÒ²¿ÉÓÃÓÚÒ©ÎïºÏ³É¹¤ÒÕµÄÉè¼Æ¡£ÀîÀÖ½ÌÊÚÍŶÓÒÔ»Çõ£·ú×÷ΪÖÐÐÄÌåÉè¼ÆÁËÒ»Ìõ¹ÇËèÏËά»¯Ò©Îï·Æ×¿ÌæÄᣨFedratinib£©¼°ÆäÑÜÉúÎïµÄȫкϳÉõè¾¶£¬ÎªÒ©ÎïºóÆÚ¹ÙÄÜ»¯ºÍÏȵ¼»¯ºÏÎïµÄɸѡÌṩÁËеÄ;¾¶¡£

¸ÃÑо¿Ð§¹û½ÒÏþÔÚAngewandte Chemie International EditionÉÏ¡£ÀîÀÖ½ÌÊÚ¿ÎÌâ×éµÄ²©Ê¿ÉúκÃ÷½Ü£¬Áº´ó³É²©Ê¿ºÍ¹ã¶«Ò©¿Æ´óѧ²ÜС»Ô²©Ê¿Îª¸ÃÂÛÎĵÄÅäºÏµÚÒ»×÷Õߣ¬ÀîÀÖ½ÌÊÚΪΨһͨѶ×÷Õß¡£¸ÃÊÂÇé»ñµÃÁ˹ú¼Ò×ÔÈ»¿ÆÑ§»ù½ð£¬¹ã¶«Ê¡×ÔÈ»¿ÆÑ§»ù½ðµÈÏîÄ¿µÄ×ÊÖú¡£

ÂÛÎÄÁ´½Ó£º£ºhttps://onlinelibrary.wiley.com/doi/10.1002/anie.202013976

¡¾ÍøÕ¾µØÍ¼¡¿