ÕæºËϸ°ûȾɫÌåͨ³£»£»£»áÓÐÐòµÄÕÛµþ£¬£¬ÔÚ¿Õ¼äÉÏ»áÐγÉÓÐÐòµÄÈýά½á¹¹¡£¡ £¡£ÕâЩÈýά½á¹¹ÓÉ´óµ½Ð¡Ö÷Òª·ÖΪÇøÊÒÍÑÀ루compartments£©¡¢¡¢¡¢ÍØÆËÏà¹Ø½á¹¹Óò£¨Topological-Associated Domains,TADs£©ÒÔ¼°È¾É«ÖÊ»·×´½á¹¹£¨loops£©µÈ¡£¡ £¡£Ï¸°ûÔËÆøת±äÀú³ÌÖÐÍùÍùÅãͬ×ÅȾɫÌåÈýά½á¹¹µÄÇ¿ÁÒת±ä£¬£¬¶øÕâЩת±ä¹ØÓÚÍƶ¯Ï¸°ûÔËÆøת±äµÄ¾ÙÐÐÆðµ½Ö÷Òª×÷Óᣡ £¡£TADͨ³£±»ÒÔΪÊÇÒ»ÖÖÏà¶ÔÊؾɵĽṹ£¬£¬ÔÚ²î±ðÎïÖÖºÍͳһÎïÖֵIJî±ðϸ°ûÖ®¼äÇ÷ÓÚÎȹ̡£¡ £¡£È»¶ø½üÄêÀ´µÄÑо¿·¢Ã÷£¬£¬ÔÚϸ°û·Ö»¯µÄÀú³ÌÖУ¬£¬TADµÄÊýÄ¿ºÍ¾Þϸ¶¼»á±¬·¢×ª±ä£¬£¬Õâ˵Ã÷TADÔÚϸ°ûÔËÆøת±äÀú³ÌÖÐÓпÉÄܱ¬·¢ÁËÖØ×é¡£¡ £¡£Òò´Ë£¬£¬Ì½ÌÖTADÖØ×éÒòËؼ°ÆäºÍϸ°ûÔËÆøת»»Ö®¼äµÄ¹ØϵÓÈΪÖ÷Òª¡£¡ £¡£
5ÔÂ25ÈÕ£¬£¬ngµç×ÓÓÎÏ·ÖÐɽҽѧԺ¶¡¿¡¾üʵÑéÊÒÔÚCell Stem CellÉϽÒÏþÁËÌâΪ¡°Phase separation of OCT4 controls TAD reorganization to promote cell fate transitions¡± µÄÎÄÕ£¬£¬Ê×´ÎÆÊÎöÁËÒªº¦×ªÂ¼Òò×ÓOCT4ͨ¹ýÏàÊèÉ¢£¨phase separation£©»úÖƵ÷¿ØTADÖØ×éÒÔÍƶ¯Ìåϸ°ûÖرà³ÌµÄ¾ÙÐС£¡ £¡£¸ÃÑо¿ÊǵÚһƪÐðÊöÏàÊèÉ¢»úÖƵ÷¿ØȾɫÖʸ߼¶½á¹¹ÒÔÍƶ¯Ï¸°ûÔËÆøת±äµÄÎÄÕ¡£¡ £¡£
OCT4ÏàÊèɢͨ¹ýÓÕµ¼TADÖØ×éµ÷¿Øϸ°ûÔËÆø
ÔÚ¸ÃÏîÑо¿ÖУ¬£¬Ñо¿Ö°Ô±Ê×ÏȶÔÌåϸ°ûÖرà³Ì²î±ðʱÆÚ¾ÙÐÐÁËÈýά»ùÒò×éѧ¡¢¡¢¡¢ÂÑ°××éѧ¡¢¡¢¡¢×ªÂ¼×éѧºÍ±í¹Û×éѧµÈ¶à×éѧµÄËÄάÕûºÏÐÔÆÊÎö£¬£¬Í¨¹ýÕâЩÆÊÎö»ñµÃÁËÖرà³ÌÀú³ÌÖÐÒÔTADÖØ×éΪ½¹µãµÄȾɫÌåÈýά½á¹¹µÄת±äÌص㣻£»£»ÐðÊöÁËOCT4½éµ¼µÄȾɫÌå»·×´½á¹¹µÄ¶¯Ì¬×ª±äͨ¹ý¸Ä±äTAD½çÏßÉÏCTCFµÄÁ¬ÏµÒÔµ÷¿ØTADÖØ×éµÄлúÖÆ£»£»£»½øÒ»²½·¢Ã÷OCT4µÄÏàÊèÉ¢ÌØÕ÷¿Éµ÷¿ØTADÖØ×éºÍϸ°ûÔËÆøת±ä£»£»£»½ø¶ø·¢Ã÷£¬£¬Í¨¹ý²Ù¿ØTADÖØ×éºÍOCT4µÄÏàÊèÉ¢£¬£¬¿ÉÒÔµ÷¿Øϸ°ûÔËÆøת±ä£»£»£»×îÖÕͨ¹ý»ùÓÚTADÖØ×éµÄÐÂËã·¨ÅжϳöÁËÐÂÐÍϸ°ûÔËÆøµ÷¿ØÒò×Ó£¬£¬²¢¶ÔÕâЩÐÂÐÍϸ°ûÔËÆøµ÷¿ØÒò×Ó×öÁ˹¦Ð§ÑéÖ¤¡£¡ £¡£
¸ÃÂÛÎÄÊ״η¢Ã÷ÂÑ°×ÖÊÏàÊèÉ¢¡¢¡¢¡¢È¾É«ÖÊÈýά½á¹¹ºÍϸ°ûÔËÆøת±äÖ®¼äµÄµ÷¿Ø»úÖÆ£¬£¬½¨ÉèÁËͨ¹ý²Ù¿ØTADÖØ×é¡¢¡¢¡¢ºÍ¿ØÖÆÂÑ°×ÖÊÏàÊèÉ¢£¬£¬´Ó¶øµ÷¿Øϸ°ûÔËÆøµÄÐÂÒªÁ죬£¬Ò²¿ª·¢ÁË»ùÓÚȾɫÖÊÈýά½á¹¹¾«×¼Ô¤²âϸ°ûÔËÆøµ÷¿ØÒò×ÓµÄÐÂËã·¨¡£¡ £¡£
ngµç×ÓÓÎÏ·ÖÐɽҽѧԺÑо¿Ô±Íõ¼Ñ²©Ê¿ÎªÂÛÎĵÚÒ»×÷Õߣ¬£¬ËÄ´¨´óѧ»ªÎ÷Ò½ÔºÓÚºÆÅ첩ʿ¡¢¡¢¡¢ÖÐɽҽѧԺ²©Ê¿Ñо¿ÉúÂíٻΪ¸ÃÂÛÎÄÅäºÏµÚÒ»×÷Õߣ¬£¬ÖÐɽҽѧԺ¶¡¿¡¾ü½ÌÊÚΪÂÛÎÄΨһͨѶ×÷Õß¡£¡ £¡£
ÂÛÎÄÁ´½Ó£ºhttps://www.cell.com/cell-stem-cell/fulltext/S1934-5909(21)00181-8
µØµã:¹ãÖÝÊÐиÛÎ÷·135ºÅ Óʱà:510275
µç»°: 020-84112828
ngµç×ÓÓÎÏ·°æȨËùÓÐ COPYRIGHT?1999-2022 , SUN YAT-SEN UNIVERSITY