ngµç×ÓÓÎÏ·

05

¿ÆÑÐÏ£Íû

ÉúÃü¿ÆÑ§Ñ§Ôº´ÞöÁ¿ÎÌâ×éÕ¹ÏÖÑ¡ÔñÐÔ×ÔÊÉͨ¹ý½µ½âTBK1ά³ÖÃâÒ߯½ºâµÄлúÖÆ

¸å¼þȪԴ£º£º£ºÉúÃü¿ÆÑ§Ñ§Ôº ÔĶÁÁ¿£º£º£º

¹ÌÓÐÃâÒßÊÇËÞÖ÷·ÀÓùÈëÇÖ»úÌåµÄ²¡Ô­Î¢ÉúÎïµÄµÚÒ»µÀ·ÀÏß¡£¡£¡£Ñ¬È¾²¡¶¾ºó£¬£¬»úÌåͨ¹ýģʽʶ±ðÊÜÌåʶ±ð²¡¶¾µÄDNA»òRNA£¬£¬´Ó¶ø¿ìËÙÆô¶¯¹ÌÓÐÃâÒߺͿ¹²¡¶¾·´Ó³£¬£¬ÒÖÖÆ²¡¶¾µÄ¸´ÖÆ£¬£¬½ø¶øÓÐÓÃɨ³ýÈëÇֵIJ¡¶¾¡£¡£¡£ÔÚ¸Ð֪ΣÏÕÐźźó£¬£¬µ÷¿ØÏ¸°û¿¹²¡¶¾ÃâÒßµÄÒªº¦¼¤Ã¸TBK1£¨TANK-binding kinase 1£©±»¼¤»î£¬£¬²¢½øÒ»²½Á×Ëữת¼Òò×ÓIRF3£¬£¬Ê¹ÆäÈëºË£¬£¬ÓÕµ¼ÏÂÓÎ×ÌÈÅËØµÄ±¬·¢¡£¡£¡£TBK1ÊǹÌÓÐÃâÒßϸ°û¿¹²¡¶¾ÐźÅͨ·µÄÖÐÐĽڵ㣬£¬ÈôÊÇÆä»îÐÔ²»ÊÜ¿ØÖÆ£¬£¬¿ÉÄܵ¼ÖÂ×ÔÉíÃâÒß¼²²¡ºÍÂýÐÔÑ×Ö¢µÈ¼²²¡¡£¡£¡£¶àÖÖ·­ÒëºóÐÞÊμÓÈëTBK1»îÐԵĵ÷¿Ø£¬£¬°üÀ¨Á×Ëữ£¬£¬·ºËØ»¯£¬£¬SUMO»¯¼°ÒÒõ£»£»£»¯¡£¡£¡£´ÞöÁ½ÌÊÚÍŶÓÔøÕ¹ÏÖNLRP4-USP38ÖáÄܹ»µ÷¿ØTBK1ͨ¹ý·ºËØ-ÂѰ×øÌå;¾¶½µ½â£¨Nature Immunology 2012; Molecular Cell 2016£©£¬£¬È»¶ø£¬£¬ÊÇ·ñ±£´æÆäËûµÄ½µ½âϵͳ׼ȷµ÷¿ØTBK1µÄÎȹÌÐÔÏÖÔÚÉв»Ã÷È·¡£¡£¡£

ϸ°û×ÔÊÉÊÇÕæºËÉúÎïÌåÄڵĸ߶ÈÊØ¾ÉµÄ½µ½âϵͳ£¬£¬Äܹ»½µ½âϸ°ûÄÚÓꦵÄÂѰ×Ⱥ¼¯Îï¡¢¡¢ÀÏ»¯µÄϸ°ûÆ÷ºÍÇÖȾ»úÌåµÄ²¡Ô­Î¢ÉúÎïµÈ£¬£¬ÔÚά³Ö»úÌåÄÚÎÈ̬Àú³ÌÖÐʩչ²»¿É»òȱµÄ×÷Óᣡ£¡£Ï¸°û×ÔÊÉÄܹ»ÆÕ±éµØ¼ÓÈë¹ÌÓÐÃâÒßÀú³Ì£º£º£ºÒ»·½Ã棬£¬Ï¸°û×ÔÊÉ¿ÉÒÔÖ±½Ó½µ½âɨ³ýÈëÇֵIJ¡Ô­Î¢ÉúÎ£»£»ÁíÒ»·½Ã棬£¬Ñ¡ÔñÐÔ×ÔÊÉ¿ÉÒÔͨ¹ý½µ½â¿¹²¡¶¾ÃâÒßÍøÂçÖеĽ¹µã·Ö×Ó£¬£¬Î¬³ÖÃâÒß·´Ó³µÄÎÈ̬¡£¡£¡£ÓÐȤµÄÊÇTBK1ÔÚ×ÔÊÉÀú³ÌÖÐҲʩչÁËÖ÷ÒªµÄ×÷Ó㬣¬Ëü²»µ«¿ÉÒÔͨ¹ýÔö½øULK1¸´ºÏÌåµÄÐγÉÔö½ø×ÔÊÉ£»£»£»»¹¿ÉÒÔͨ¹ýµ÷Àí×ÔÊÉʶ±ðÊÜÌåµÄ»îÐÔ£¬£¬Ôö½øÑ¡ÔñÐÔ×ÔÊÉ¡£¡£¡£ÕâЩÑо¿ÌáÐÑTBK1¿ÉÄÜÔÚϸ°û×ÔÊɺͿ¹²¡¶¾ÃâÒßµÄcrosstalkÖÐʩչÖ÷Òª×÷Óᣡ£¡£

´ÞöÁ½ÌÊÚÍŶӷ¢Ã÷£¬£¬NEDD4Äܹ»ÏÔÖøÒÖÖÆ¿¹²¡¶¾ÃâÒß·´Ó³¼°Ôö½ø²¡¶¾¸´ÖÆ¡£¡£¡£NEDD4ÔÚ²¡¶¾Ñ¬È¾ÖÐÁ¬ÏµTBK1£¬£¬²¢ÏÔÖøÔö½øTBK1µÄ½µ½â£¬£¬¿ÉÊÇÔÚÎÞ²¡¶¾ÇÖȾʱ£¬£¬NEDD4²»Ó°ÏìTBK1µÄÎȹÌÐÔ¡£¡£¡£½øÒ»²½Ñо¿·¢Ã÷ÕâÊÇÓÉÓÚNEDD4Ö÷Òª°ÐÏòÁ×ËữµÄTBK1£¨p-TBK1£©£¬£¬²¢´Ùʹp-TBK1±¬·¢×ÔÊɽµ½â¡£¡£¡£µ±TBK1µÄÁ×Ëữλµã£¨S172£©Í»±äºó£¬£¬NEDD4²»ÔÙÄܹ»ÓëÖ®Á¬Ïµ²¢Ôö½øÆä±¬·¢×ÔÊɽµ½â¡£¡£¡£NEDD4´Ùʹ¼¤»îµÄTBK1ÔÚK344λµã±¬·¢K27ÀàÐ͵ķºËØ»¯ÐÞÊΡ£¡£¡£Ñ¡ÔñÐÔ×ÔÊÉʶ±ðÊÜÌåNDP52ͨ¹ýK27ÀàÐ͵ķºËØÁ´Ê¶±ðTBK1²¢½«ÆäÔËËÍÖÁ×ÔÊÉÈÜøÌåÖоÙÐнµ½â¡£¡£¡£ÒÔÍùµÄÑо¿Åú×¢ÔÚ²¡¶¾ÇÖȾµÄÔçÆÚ£¬£¬TBK1»á±¬·¢K48ÀàÐ͵ķºËØÐÞÊΣ¬£¬½ø¶øÍ¨¹ý·ºËØ-ÂѰ×øÌå;¾¶½µ½â¡£¡£¡£¸ÃÑо¿½øÒ»²½Õ¹ÏÖÔÚ²¡¶¾ÇÖȾµÄºóÆÚ£¬£¬¼¤»îµÄTBK1Ö÷Òª±¬·¢K27ÀàÐ͵ķºËØÐÞÊΣ¬£¬Ê¹µÃTBK1ͨ¹ýÑ¡ÔñÐÔ×ÔÊɽµ½â;¾¶½øÒ»²½½µ½â£¬£¬·ÀÖ¹TBK1±»Ì«¹ý¼¤»î¡£¡£¡£Òò´Ë£¬£¬NEDD4½éµ¼µÄTBK1µÄ×ÔÊɽµ½â¹ØÓÚά³Ö¿¹²¡¶¾ÃâÒ߯½ºâ¾ßÓÐÖ÷ÒªµÄ×÷Óᣡ£¡£

Ê×Ò³|ngµç×ÓÓÎÏ·Öйú¼¯ÍŹٷ½ÍøÕ¾

NEDD4½éµ¼µÄÑ¡ÔñÐÔ×ÔÊÉͨ¹ý½µ½âTBK1ά³ÖÃâÒ߯½ºâµÄÊÂÇéģʽͼ

¸ÃÑо¿Ð§¹û¡°Selective autophagy controls the stability of TBK1 via NEDD4 to balance host defense¡±½ÒÏþÔÚCell Death & DifferentiationÔÓÖ¾ÉÏ¡£¡£¡£¸ÃÑо¿Õ¹ÏÖÁËNEDD4ͨ¹ý½éµ¼Á×ËữµÄTBK1±¬·¢K27ÀàÐ͵ķºËØ»¯ÐÞÊΣ¬£¬½ø¶øÊ¹Æä±»»õÎïÊÜÌåNDP52ʶ±ð²¢ÔËÊäÖÁ×ÔÊÉÈÜøÌåÖнµ½â£¬£¬´Ó¶ø·ÀÖ¹TBK1Ì«¹ý¼¤»î£¬£¬Î¬³Ö»úÌåÃâÒ߯½ºâµÄлúÖÆ¡£¡£¡£

ngµç×ÓÓÎÏ·ÉúÃü¿ÆÑ§Ñ§Ôº´ÞöÁ½ÌÊÚΪ¸ÃÂÛÎĵÄͨѶ×÷Õߣ¬£¬Ð»Î°ºì²©Ê¿ÎªÂÛÎĵÚÒ»×÷Õß¡£¡£¡£¸ÃÑо¿»ñµÃ¹ú¼Ò×ÔÈ»¿ÆÑ§»ù½ðµÈÏîÄ¿×ÊÖú¡£¡£¡£

ÂÛÎÄÁ´½Ó£º£º£ºhttps://doi.org/10.1038/s41418-021-00833-9

¡¾ÍøÕ¾µØÍ¼¡¿