ngµç×ÓÓÎÏ·

03
Ê×Ò³ / ½Ìѧ¿ÆÑÐ / ÕýÎÄ

¶Î¾§¾§¿ÎÌâ×éÕ¹ÏÖµ¥Ï¸°ûˮƽлúÖÆ

¸å¼þȪԴ£º£ºÖÐɽҽѧԺ ±à¼­£º£ºÎâÁ¢¼á ÉóºË£º£ºËïÒ«±ó É󶨣º£º»ÆÑÞ ÔĶÁÁ¿£º£º

ngµç×ÓÓÎÏ·ÐÂÎÅÍø£¨Í¨Ñ¶Ô± ÕÅÓñçù£©¿ËÈÕ£¬£¬£¬Éñ¾­¿ÆѧÖÐÐÄÑÕ¹âÃÀ¡¢¡¢¶Î¾§¾§¿ÎÌâ×éÊ×´ÎÔÚÌåÄÚµ¥Ï¸°ûˮƽÉÏÕ¹ÏÖÁËGABAARsÓëNMDARÖ®¼ä±£´æÌØÒìÐÔ¹¦Ð§ñîºÏ£¬£¬£¬ÎªÃ÷È·Ð˷ܨCÒÖÖÆƽºâÌṩÁËÈ«ÐÂÊӽǣ¬£¬£¬Ïà¹ØЧ¹û½ÒÏþÓÚ¡¶EMBO reports¡·£¨¡¶Å·ÖÞ·Ö×ÓÉúÎïѧѧ»á±¨¸æ¡·£©¡£¡£¡£¶Î¾§¾§¸±½ÌÊÚΪ¸ÃÂÛÎĵĵÚÒ»×÷Õß¼æͨѶ×÷Õß¡£¡£¡£

GABAAÊÜÌ壨GABAARs£©ÊÇÖÐÊàÉñ¾­ÏµÍ³Ö÷ÒªµÄÒÖÖÆÐÔÉñ¾­µÝÖÊÊÜÌ壬£¬£¬ÔÚά³ÖÉñ¾­ÍøÂçÐ˷ܨCÒÖÖÆƽºâ£¨E/I balance£©¼°Õý³£ÄÔ¹¦Ð§ÖÐÊ©Õ¹½¹µã×÷Óᣡ£¡£È»¶ø£¬£¬£¬GABAARsÔÚµ¥Ï¸°ûˮƽÉÏÔõÑùµ÷¿ØÐË·ÜÐÔÍ»´¥¹¦Ð§£¬£¬£¬Æä·Ö×Ó»úÖƲ¢²»ÇåÎú¡£¡£¡£

ÔÚ¸ÃÑо¿ÖУ¬£¬£¬¿ÎÌâ×é½ÓÄÉCRISPR-Cas9ÊÖÒÕͬʱÇóýСÊóº£ÂíCA1׶ÌåÉñ¾­ÔªÖÐGABAARµÄ¦Â1¡¢¡¢¦Â2¡¢¡¢¦Â3ÑÇ»ù»ùÒò£¨GABRB1-3£©£¬£¬£¬ÊµÏÖµ¥¸öϸ°ûˮƽµÄGABAAR¹¦Ð§µÄĬȻ¡£¡£¡£È«Ï¸°ûĤƬǯ¼Í¼ÏÔʾ£¬£¬£¬È±Ê§GABAARs²¢²»Ó°ÏìAMPAR½éµ¼µÄÍ»´¥×ª´ï£¬£¬£¬È´ÏÔÖø½µµÍÁËNMDAR½éµ¼µÄÍ»´¥µçÁ÷£¬£¬£¬²¢Ê¹NMDARÒÀÀµµÄ³¤Ê±³ÌÔöÇ¿£¨LTP£©ÍêÈ«Ëðʧ£¬£¬£¬Í¬Ê±ÅãͬСÊó¿Õ¼äÓ°ÏóÄÜÁ¦ÏÔÖøϽµ¡£¡£¡£»£»£»ùÒò¹¦Ð§Õü¾ÈʵÑé֤ʵ£¬£¬£¬NMDAR¹¦Ð§ÒÀÀµÓÚÌض¨ÑÇÐ͵ÄGABAAR£¬£¬£¬²¢Êܵ½Éñ¾­Ôª×ÔÉíÐË·ÜÐÔϸÄåµ÷¿Ø¡£¡£¡£½øÒ»²½µÄÒ©Àíѧ¸ÉÔ¤Åú×¢£¬£¬£¬»Ö¸´ NMDAR ¹¦Ð§¿ÉÄæת GABAARȱʧµ¼Ö嵀 LTP ÕÏ°­¼°¿Õ¼äÓ°ÏóȱÏÝ£¬£¬£¬´Ó¶øÕ¹ÏÖÁË GABAARÊÜÌåÓë NMDAR ¹¦Ð§¼äµÄÌØÒìÐÔñîºÏ»úÖÆ¡£¡£¡£

¹Å°å¿´·¨ÒÔΪ£¬£¬£¬Ð˷ܨCÒÖÖÆƽºâÖ÷ÒªÒÀÀµÓÚAMPAR½éµ¼µÄÐË·ÜÐÔÍ»´¥×ª´ïÓëGABAAR½éµ¼µÄÒÖÖÆÐÔÍ»´¥×ª´ïÖ®¼äµÄÏ໥µ÷Àí¡£¡£¡£È»¶ø£¬£¬£¬½üÆÚÑо¿·¢Ã÷£¬£¬£¬GABAÄÜÒÖÖÆÐÔת´ïµÄÏ÷Èõ²¢²»×ÜÊÇÅãͬAMPAR½éµ¼µÄÐË·ÜÐÔת´ïϽµ£¬£¬£¬Õâ¶ÔE/IƽºâÒÀÀµAMPARÓëGABAARÏ໥Эµ÷µÄ¾­µäÍ»´¥ÎÈ̬¿ÉËÜÐÔ£¨Homeostatic plasticity£©ÀíÂÛÌá³öÁËÌôÕ½¡£¡£¡£±¾Ñо¿ÔÚµ¥Ï¸°ûˮƽÉÏÕ¹ÏÖÁËÒ»¸öȫеĻúÖÆ¡ª¡ªGABAAR¿ÉͨÏ꾡°û×ÔÖ÷·½Ê½ÌØÒìÐÔµ÷¿ØNMDAR½éµ¼µÄÍ»´¥×ª´ïÓë¿ÉËÜÐÔ£¬£¬£¬´Ó¶øÐγÉÒ»ÖÖ»ùÓÚÍ»´¥NMDAR¨CGABAAR¹¦Ð§ñîºÏµÄÆæÒìE/IƽºâÐÎʽ¡£¡£¡£¼øÓÚNMDAR¼°E/IƽºâÔÚѧϰ¡¢¡¢Ó°Ï󼰸߼¶ÈÏÖª¹¦Ð§ÖеĽ¹µã×÷Ó㬣¬£¬ÕâÒ»»úÖÆÔÚÒÔÈÏÖªÕÏ°­ÎªÖ÷ÒªÌØÕ÷µÄ¶àÖÖÉñ¾­ÏµÍ³¼²²¡ÖпÉÄܾßÓÐÖ÷ÒªµÄ²¡ÀíѧÓëÖÎÁÆѧÒâÒå¡£¡£¡£

ÂÛÎÄÁ´½Ó£º£º https://doi.org/10.1038/s44319-025-00538-x

¡¾ÍøÕ¾µØͼ¡¿