ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶(ͨѶԱÕÂÖÇçù£©6ÔÂ9ÈÕ£¬Á¥ÊôµÚÒ»Ò½Ôº¾«×¼Ò½Ñ§Ñо¿ÔºÌƲßÑо¿Ô±ÍŶÓÁªºÏÉîÛÚÊжùͯҽԺ¡¢¡¢¹ãÖÝÖÐÒ½Ò©´óѧÍŶӿªÕ¹µÄÒ»ÏîÑо¿£¬Ñо¿Ê×´Î֤ʵ£¬·ÎÅݾÞÊÉϸ°û»áͨ¹ýʶ±ð´Ó³¦µÀ×ªÒÆµ½·Î²¿µÄ¹²ÉúÕæ¾ú£¬¼¤»î×ÔÉí´ÙÏËά»¯µÄ²¡Àí¹¦Ð§£¬ÎªÒÔºóÒÔ¹ÌÓÐÃâÒßϸ°ûºÍ¹²ÉúÕæ¾úΪ°Ðµã£¬ÖÎÁƺÍÔ¤·ÀÏËά»¯ÐÔ¼²²¡ÌṩÁË¿ÆÑ§ÒÀ¾Ý¡£Ïà¹ØÑо¿Ð§¹û½ÒÏþÓÚÃâÒßѧ¹ú¼Ê¶¥¼¶ÆÚ¿¯Immunity¡£
·ÎÏËά»¯ÊÇÒ»ÖÖÂýÐÔ¾ÙÐÐÐÔ¼²²¡£¬Ö÷ÒªÌØÕ÷ÊÇ·Î×éÖ¯½á¹¹±»ÆÆË𣬷μäÖÊ·ºÆðÏËάÑùÖØËÜ¡£Æä²¡ÀíÀú³Ìͨ³£ÌåÏÖΪ·Î¼äÖʳÉÏËάϸ°û³ÖÐø»î»¯£¬´ó×Ú½ºÔÂѰ׵Èϸ°ûÍâ»ùÖÊÒòËØ³Á»ý£¬×îÖÕµ¼Ö·ι¦Ð§Öð½¥Ëðʧ¡£
·ÎÏËά»¯µÄÓÕ·¢ÒòËØÓÐÐí¶à£¬°üÀ¨ÇéÐζ¾Îï̻¶¡¢¡¢×ÔÉíÃâÒßʧµ÷¡¢¡¢ÂýÐÔѬȾµÈ¡£ÏÖÔÚ£¬TGF-¦ÂÐźÅÓë½ðÊô»ùÖÊÂѰ×øµÈµ÷¿Ø»úÖÆÔÚ·ÎÏËά»¯ÖеÄ×÷ÓÃÒѱ»ÉîÈëÑо¿£¬µ«·ÎÄÚ¹²Éú΢ÉúÎïȺ£¬ÓÈÆäÊÇÕæ¾úȺÂäÔڸò¡ÖеļÓÈë»úÖÆÒ»Ö±²»ÎªÈËÖª¡£
Dectin-1£¨»ùÒòClec7a£©ÊôÓÚCÐÍÄý¼¯ËØÊÜÌå¼Ò×å³ÉÔ±£¬ÆÕ±é±í´ïÓÚ¾ÞÊÉϸ°û¡¢¡¢Ê÷ͻ״ϸ°ûµÈËèϵ¹ÌÓÐÃâÒßϸ°ûÍâò£¬Äܹ»Ê¶±ðÕæ¾úϸ°û±ÚÖеĦÂ-ÆÏ¾ÛÌÇ£¬½ø¶ø¼¤»îÏÂÓÎÃâÒßÐźÅͨ·¡£
ËäÈ»ËüÔÚËÞÖ÷¿¹Õæ¾ú·ÀÓùÖеÄ×÷ÓÃÒѱ»ÏµÍ³ÆÊÎö£¬µ«ÔÚÏËά»¯ÐÔ¼²²¡ÖпÉÄܱ£´æµÄµ÷¿Ø¹¦Ð§»¹²»ÇåÎú¡£
Ñо¿ÍŶÓÔÚÌØ·¢ÐÔ·ÎÏËά»¯»¼ÕߵķÎ×éÖ¯Ñù±¾ºÍ²©À´Ã¹ËØÓÕµ¼µÄ·ÎÏËά»¯Ð¡ÊóÄ£×ÓÖж¼ÊӲ쵽£¬Dectin-1µÄ±í´ïˮƽÏÔÖøÉϵ÷£¬ÇÒÖ÷ÒªÂþÑÜÔÚ·ÎÅݾÞÊÉϸ°ûȺÌåÖС£½øÒ»²½µÄÌåÄÚÍâʵÑé֤ʵ£¬Dectin-1»î»¯ºó£¬»á´Ùʹ¾ÞÊÉϸ°û´Ó¾²Ï¢ÐÍת±äΪ´ÙÏËά»¯±íÐÍ£¬Í¬Ê±ÅãͬTGF-¦ÂÓë½ðÊô»ùÖÊÂѰ×øµÄÉϵ÷£¬½ø¶øÔö½ø»ùÖÊÖØ¹¹ºÍ³ÉÏËάϸ°û»î»¯¡£

·ÎÏËά»¯²¡È˺ÍСÊóµÄ·ÎÅݾÞÊÉϸ°ûͨ¹ýDectin-1ÐźÅת»¯Îª´ÙÏËά»¯ÐÔϸ°û
ΪÁËÕÒµ½Dectin-1µÄÉÏÓ줻îÒò×Ó£¬Ñо¿Ö°Ô±½ÓÄÉDectin-1FcÈÚºÏÂѰ×Á¬ÏµITS¸ßͨÁ¿²âÐòÊÖÒÕ£¬´Ó·Î²¿¹²ÉúÕæ¾úȺÖÐÀֳɸ»¼¯²¢×÷Óý³öÒ»ÖêDectin-1¸ßÇ׺ÍÐÔÕæ¾ú¡ª¡ª²à³ÝùÊô¡£
ÔÚ¶¯ÎïÄ£×ÓÖУ¬¸ÃÕæ¾úÔڷβ¿¶¨Ö²ºó£¬ÏÔÖø¼ÓÖØÁËÏËά»¯µÄ²¡ÀíÌØÕ÷£¬¶øÔÚDectin-1»ùÒòÇóýСÊóÖУ¬ÏËά»¯³Ì¶ÈÏÔ׿õÇᣬÕâ֤ʵÁËÆäÖ²¡»úÖÆÒÀÀµÓÚDectin-1½éµ¼µÄʶ±ðÀú³Ì¡£
ÔÚÐźŻúÖÆ·½Ã棬ֻ¹ÜCARD9±»ÒÔΪÊÇDectin-1µÄ¾µäÏÂÓÎÊÊÅä·Ö×Ó£¬µ«CARD9Çóý»òÆäÉÏÓÎDectin-2ÇóýµÄСÊóÄ£×Ó²¢Ã»ÓзºÆðÏËά»¯»º½âµÄÕ÷Ïó£¬ÕâÅú×¢±£´æCARD9·ÇÒÀÀµÐÔÐźÅͨ·¼ÓÈëÆäÖС£
½øÒ»²½Ñо¿·¢Ã÷£¬Raf1×÷ΪDectin-1¼¤»îµÄÒªº¦·Ö×Ó£¬ÒÖÖÆÆä¹¦Ð§¿ÉÒÔÓÐÓûº½âÏËά»¯³Ì¶È£¬ïÔ̽ºÔ³Á»ý¡£ÕâÒ²ÌáÐÑ£¬¡°Dectin-1¨CRaf1¡±Êǽ鵼²à³ÝùÊôÕæ¾úÖ²¡Ð§Ó¦µÄÖ÷ÒªÐźÅÖᣬ¶ø·Ç¡°Dectin-1¨CCARD9¡±¡£
¸ÃÑо¿²»µ«Ìî²¹ÁËÕæ¾úÐԷι²ÉúȺÔÚÏËά»¯²¡ÀíÖмÓÈë»úÖÆµÄÑо¿¿Õȱ£¬»¹Ê×´Î֤ʵ·ÎÅÝפÁôµÄ¾²Ï¢¾ÞÊÉϸ°û¿Éͨ¹ýDectin-1ÐźÅת»¯Îª´ÙÏËά»¯¾ÞÊÉϸ°û£¬ÕâÇ㸲ÁËÒÔÍùÆÕ±éÒÔΪ·ÎÅÝ´ÙÏËά»¯¾ÞÊÉϸ°ûÓÉÍâÖܵ¥ºËϸ°û½þÈó·Ö»¯¶øÀ´µÄÈÏÖª¡£
±ðµÄ£¬Õë¶ÔDectin-1¨CRaf1ÖáµÄ°ÐÏò¸ÉÔ¤Õ½ÂÔ£¬ÓÐÍûΪδÀ´·ÎÏËά»¯¼°ÆäËû΢ÉúÎï-ÃâÒß»¥×÷Ïà¹Ø¼²²¡ÌṩеÄÖÎÁÆË¼Ð÷¡£

ÂÛÎÄÁ´½Ó£º£º£ºhttps://www.cell.com/immunity/abstract/S1074-7613(25)00228-6