ngµç×ÓÓÎÏ·

03
Ê×Ò³ / ½Ìѧ¿ÆÑÐ / ÕýÎÄ

ÉúÃü¿ÆÑ§Ñ§ÔºÂ½Ó¾ü½ÌÊÚÍŶÓÓëÁ¥ÊôÁùÔºÍõ»Ô½ÌÊÚÍŶÓÏàÖúÕ¹ÏÖ·øÉäÓÕµ¼µÄ³¦µÀ¾úȺºÍ´úлʧµ÷½éµ¼·ÅÉäÐÔÖ±³¦²¡µÄ·¢²¡»úÖÆ

¸å¼þȪԴ £º£ºÉúÃü¿ÆÑ§Ñ§Ôº ±à¼­ £º£ºÂ¬ì½Î¬ ÉóºË £º£ºËïÒ«±ó ÔĶÁÁ¿ £º£º

ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶£¨Í¨Ñ¶Ô±ÐÜÀöÄÈ£©·ÅÉäÐÔÖ±³¦²¡£ ¡£¨RP£©ÊÇÅèÇ»¶ñÐÔÖ×Áö£¨ÈçǰÏßÏÙ¡¢Ö±³¦ºÍ×Ó¹¬Ö×ÁöµÈ£©·ÅÉäÖÎÁƺóµÄ³£¼û¸±×÷Ó㬷¢²¡Âʸߣ¬¶øÁÙ´²ÉÏȱ·¦ÓÐÓõÄÖÎÁÆÒªÁì¡£ ¡£·øÉä»áµ¼Ö³¦µÀ¾úȺµÄʧµ÷£¬È»¶ø£¬RPÖмÓÈëËÞÖ÷-΢ÉúÎïȺÏ໥×÷ÓõĹ²´úл²úÆ·ºÍµ÷ÀíÍøÂçÌØÕ÷ÉÐδÆÊÎö¡£ ¡£

ÉúÃü¿ÆÑ§Ñ§ÔºÂ½Ó¾ü½ÌÊÚÍŶÓÓëÁ¥ÊôÁùÔºÍõ»Ô½ÌÊÚÍŶÓʹÓÃRPСÊóÄ£×ӺͶà×éѧսÂÔÀ´±íÕ÷³¦µÀ¾úȺ¼°Æä´úлÎïÓëËÞÖ÷ÃâÒßϵͳµÄÏ໥×÷Óã¬ÒÔÕ¹ÏÖ³¦µÀ¾úȺͨ¹ýÆä¹²´úл²úÆ·¼ÓÈë·øÉä±£»£»¤µÄ»úÖÆ¡£ ¡£´úл×éѧЧ¹ûÏÔʾ£¬RPСÊóºÍ·ÅÉäÖÎÁÆ»¼Õߵķà±ãºÍѪÇåÖ㦵À¹²´úлÎï3-ôÇ»ù¶¡Ëᣨ3HB£©Å¨¶ÈÏÔÖø½µµÍ£¬ÇÒÓë´ÙÑ×Òò×ÓIL6µÄ±í´ïˮƽ¸ºÏà¹Ø£»£»ÔÚ´Ë»ù´¡ÉÏ£¬Ñо¿ÍŶӽøÒ»²½ÆÊÎöÁË3HBÔÚ³¦µÀÑ×Ö¢ºÍ×éÖ¯ËðÉËÖÐʩչµÄ·øÉä±£»£»¤×÷Óü°Æä»úÖÆ£¬¼´3HBͨ¹ýϵ÷RPСÊóÖÐGÂѰ׿ÁªÊÜÌå43£¨GPR43£©½éµ¼µÄIL6±í´ï£¬ÏÔÖø¸ÄÉÆ·øÉäÓÕµ¼µÄËðÉË¡£ ¡£±ðµÄ£¬Î¢ÉúÎï×éÆÊÎöÏÔʾ£¬Óëδ¾­ÖÎÁƵıÈÕÕ×éÏà±È£¬·øÉä»áµ¼ÖÂRPСÊóºÍ·ÅÉäÖÎÁÆ»¼Õß³¦µÀÖÐDZÔÚÒæÉú¾úAkkermansia muciniphilaƷòÏÔÖøïÔÌ­£»£»Ð¡Êó¹àθA. muciniphilaÏÔÖøÔöÌí3HBŨ¶È£¬Ïµ÷GPR43ºÍIL6µÄ±í´ï£¬²¢¸ÄÉÆ·øÉäËðÉË¡£ ¡£ÒÔÉÏЧ¹ûÅú×¢£¬·øÉäÓÕµ¼µÄ³¦µÀ¾úȺºÍ´úлʧµ÷ÓëRPµÄ·¢²¡»úÖÆÓйØ£¬°ÐÏò¡°³¦µÀ-ÃâÒß¡±ÖáµÄ;¾¶¿ÉÏÔÖø¸ÄÉÆ·øÉäºó×éÖ¯ËðÉË¡£ ¡£¸ÃÑо¿ÎªÁÙ´²¼õÇá·øÉäÓÕµ¼µÄËðÉËÌṩÁËеÄÔ¤·ÀºÍÖÎÁÆÕ½ÂÔ¡£ ¡£

F766E78754F9094035CC89450E8_A061DE8D_B57D

¸ÃÑо¿ÓÚ2024Äê5ÔÂ14ÈÕÒÔ¡°Gut Microbiota-Derived 3-Hydroxybutyrate Blocks GPR43-Mediated IL6 Signaling to Ameliorate Radiation Proctopathy¡± ΪÌâÔÚAdvanced ScienceÉϽÒÏþ£¬ngµç×ÓÓÎÏ·ÉúÃü¿ÆÑ§Ñ§Ôº¸ðÕñ»Í¸±Ñо¿Ô±Îª¸ÃÎÄÕµĵÚÒ»×÷Õߣ¬Â½Ó¾ü½ÌÊÚ¡¢Íõ»³Ã÷¸±½ÌÊÚºÍÍõ»Ô½ÌÊÚΪ¸ÃÎÄÕµÄÅäºÏͨѶ×÷Õß¡£ ¡ £º£ÏàÖúÍŶӵijÉÔ±¶Ô¸ÃÎÄÕÂ×ö³öÁËТ˳¡£ ¡£

Ô­ÎÄÁ´½Ó £º£ºhttp://doi.org/10.1002/advs.202306217


¡¾ÍøÕ¾µØÍ¼¡¿