ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶£¨Í¨Ñ¶Ô±ÕÅÓñçù£©¿¹ÉúËØµÄ·¢Ã÷ÊÇÈËÀàÀúÊ·ÉÏ×îÖ÷ÒªµÄÉúÎïҽѧ³É¼¨Ö®Ò»¡£¡£È»¶ø£¬¿¹ÉúËØµÄ´ó×ÚʹÓôÙʹ¿¹Î¢ÉúÎïÒ©ÎïÄÍÒ©ÐÔ£¨Antimicrobial resistance£¬AMR£©¿ìËÙÑÝ»¯¡£¡£Ã¿ÄêËÀÓÚAMRÏà¹Ø¼²²¡µÄÈËÊý¸ß´ïÊý°ÙÍò¡£¡£¿ª·¢ÐÂÐÍ¿¹ÉúËØÊÇÏÖÔÚÓ¦¶ÔAMRµÄÆÕ±éÕ½ÂÔ£¬µ«ÐÂÐÍ¿¹ÉúËØÑз¢ÖÜÆÚ³¤¡¢¡¢¡¢ÄѶȴó£¬Òò¶øØ½ÐèѰÕÒÐÂÒªÁìÒÔ×èÖ¹¿¹ÉúËØÄÍÒ©ÐÔ¡£¡£ÄÍÒ©ÐԵķºÆðºÍÈö²¥ÊÇ×ÔȻѡÔñµÄÀú³Ì£¬Ï¸¾úÃæÁÙÄæ¾³£¨È翹ÉúËØÑ¹Á¦£©ÍùÍùͨ¹ýÎþÉüÒ»²¿·Ö˳ӦÐÔ£¨Fitness£©À´»ñµÃË³Ó¦Äæ¾³µÄÉúÑÄÄÜÁ¦¡£¡£Ò»µ©ÍÑÀëÄæ¾³£¬ÕâЩ˳ӦÐԽϵ͵ľúÖê¿Ë¡ÈÝÒ×±»ÆäËûÓÅÊÆÈºÌåËùÈ¡´ú¡£¡£Óë´Ëͬʱ£¬È«ÇòÐí¶à¹ú¼Ò»òµØÇøÊÔͼͨ¹ýÍ£Óÿ¹ÉúÏòÀ´×èÖ¹ÄÍÒ©ÐÔµÄÈö²¥¡£¡£È»¶ø£¬½ûÓÿ¹ÉúËØÄÜ·ñÓÐÓýµµÍÄÍÒ©ÐÔµÄÈö²¥±£´æºÜ´óÕùÒ飬ÔõÑùÌáǰÆÀ¹À½û¿¹Õ½ÂÔµÄÓÐÓÃÐÔÊÇÄ¿½ñ¸ÃÁìÓòؽÐè½â¾öµÄÒªº¦ÎÊÌâ¡£¡£
¿ËÈÕ£¬ngµç×ÓÓÎÏ·ÑÈÙ½ÌÊÚÍŶӡ¢¡¢¡¢Ìï¹ú±¦½ÌÊÚÍŶӺͳÂÐ¡Êæ½ÌÊÚÏàÖúÍŶÓÔÚLancet MicrobeÔÚÏß½ÒÏþÌâΪ¡°Assessment of the reversibility of resistance in the absence of antibiotics and its relationship with the resistance gene¡¯s fitness cost: a genetic study with mcr-1¡±µÄÑо¿ÂÛÎÄ¡£¡£¸ÃÑо¿¾Û½¹¶àÕ³¾úËØÄÍÒ©»ùÒòmcr-1£¬Ê×´ÎÌá³ö¼Ù˵£º£º£ºµ±Ï¸¾úÄÍÒ©»ùÒòͬʱÇкÏÁ½´óÌõ¼þʱ£¬½û¿¹Õ½ÂÔ½«ÄÜÓÐÓýµµÍÄÍÒ©ÐÔµÄÈö²¥¡£¡£ÕâÁ½´óÌõ¼þ°üÀ¨£º£º£º1£©ÄÍÒ©»ùÒò¾ßÓÐǿ˳ӦÐÔ¼ÛÇ®£»£»2£©ÄÍÒ©»ùÒò½ü¶ËÍ»±äÌåÖв»º¬£¨»òÉÙ¼û£©±£´æÄÍÒ©ÐÔÇÒ˳ӦÐÔ¼ÛÇ®µÍµÄÍ»±äÌ壨costless-resistant variants£©¡£¡£
Ñо¿Ö°Ô±Ê×Ïȹ¹½¨ÁËmcr-1»ùÒòÔ¼15,000ÖÖÍ»±äÌåµÄÖÊÁ£ÎĿ⣬²¢½«ÆäתÈë´ó³¦¸Ë¾úÊÜÌå¾úÖС£¡£½«Ð¯´øÓÐÒ°ÉúÐÍmcr-1¡¢¡¢¡¢mcr-1Í»±äÌåÎÄ¿âºÍÎÞ¹¦Ð§mcr-1£¨±ÈÕÕ£©µÄ´ó³¦¸Ë¾ú¾úÖê¿Ë¡»ìÏý£¬ÖÃÓÚ²î±ðŨ¶È¶àÕ³¾úËØ×÷Óý»ùÖоÙÐлìÏý×÷Óý£¬²¢Ê¹ÓÃÉî¶È²âÐòÊÖÒÕÆÊÎö»ìÏý×÷Óý²î±ðʱ¼äµãÖÖÖÖÍ»±äÌ寵ÊýµÄת±ä£¬ÅÌËãËüÃÇÏà¹ØÓÚ±ÈÕÕ¾úµÄÏà¶ÔÉú³¤ËÙÂÊ¡£¡£Ð§¹ûÏÔʾ£¬ÔÚÎÞ¶àÕ³¾úËØÇéÐÎÖУ¬Ò°ÉúÐÍmcr-1ÑôÐԴ󳦸˾úµÄÏà¶ÔÉú³¤ËÙÂÊϽµÁË73.8%£¬ÌáÐÑÒ°ÉúÐÍmcr-1»ùÒò¾ßÓкÜÇ¿µÄ˳ӦÐÔ¼ÛÇ®¡£¡£Í¬Ê±£¬µ¥µãÍ»±äÌåÖУ¬ÎÞ˳ӦÐÔ¼ÛÇ®»òµÍ˳ӦÐÔ¼ÛÇ®µÄÍ»±äÌåºÜÊǺ£º£ÓÐÊý£¨Ô¼0.1%£¬3/3449£¬ÏÂͼ£©£»£»×ÝÈ»ÄÉÈë½ø»¯ÉϸüÄѱ¬·¢µÄ¶àµãÍ»±äÌ壬ÎÞ˳ӦÐÔ¼ÛÇ®»òµÍ˳ӦÐÔ¼ÛÇ®µÄÍ»±äÌå±ÈÀýÒ²ºÜµÍ£¨Ô¼0.3%£¬43/14741£¬ÏÂͼ£©¡£¡£ÒÔÉÏЧ¹û˵Ã÷mcr-1»ùÒòȷʵÇкϽû¿¹Õ½ÂÔ×àЧµÄÁ½´óÌõ¼þ¡£¡£

Ϊ½øÒ»²½Ã÷È·ÉÏÊöÕ÷Ïó£¬Ñо¿Ö°Ô±ÆÊÎöÁË´øÓÐÌáǰÖÕÖ¹ÃÜÂë×ÓµÄÍ»±äÌå¡£¡£Ð§¹ûÅú×¢£¬ÓÉÓÚMCR-1´ÓN¶Ëµ½C¶ËÒÀ´ÎΪ¿çĤ½á¹¹Óò¡¢¡¢¡¢ÅþÁ¬½á¹¹ÓòºÍ´ß»¯½á¹¹Óò£¬¶øMCR-1¿¹ÐÔµÄά³ÖÒÀÀµÓÚÆä±àÂëµÄÍêÕû´ß»¯½á¹¹Óò£¬¶øË³Ó¦ÐÔ¼ÛÇ®ÔòÖ»ÐèÒªÍêÕûµÄ¿çĤ½á¹¹ÓòºÍÅþÁ¬ÇøÓò£¬Òò´ËÎÞÒåÍ»±äÎÞ·¨ÔÚÏû³ý˳ӦÐÔ¼ÛÇ®µÄͬʱ±£´æÄÍÒ©ÐÔ¡£¡£
×îºó£¬ÎªÁËÑéÖ¤ÕæÊµÌìÏÂÖÐMCR-1˳ӦÐÔ¼ÛÇ®ÓëÆäÊ¢ÐÐÂÊת±äÖ®¼äµÄ¹ØÏµ¡£¡£Ñо¿Ö°Ô±Í¨¹ý½ÏÁ¿ÎÒ¹ú½ûÓöàÕ³¾úËØ×÷ΪËÇÁÏÌí¼Ó¼ÁµÄÕþ²ßʵÑéÒÔÀ´£¬×¡Ôº»¼ÕßÖÐmcr-1Ê¢ÐÐÂʵĶ¯Ì¬×ª±ä£¬Ê¹ÓÃÄâºÏȺÌåÒÅ´«Ñ§Ä£×Ó£¬ÒÀ¾ÝÕæÊµÌìÏÂÖÐmcr-1µÄÏûÍËËÙÂʹÀËãÆä˳ӦÐÔ¼ÛÇ®¡£¡£Ð§¹ûÏÔʾ£¬ÕæÊµÌìϵÄÊý¾Ý£¨Éú³¤ËÙÂʱÈÎÞmcr-1¾úÖêÂý76.2%¡£¡£Í¼Öкڵ㣩ÓëÉÏÊöÔÚʵÑéÊÒ»ñµÃµÄÊý¾Ý£¨Éú³¤ËÙÂʱȱÈÕÕ¾úÂý73.8%¡£¡£Í¼ÖкìÉ«ÐéÏߣ©ºÜÊÇÎǺϡ£¡£

×ÛÉÏËùÊö£¬¸ÃÑо¿ÆÊÎöÔÚûÓжàÕ³¾úËØ¿¹ÐÔÑ¡ÔñѹÁ¦ÏÂmcr-1Ê¢ÐÐÂÊ»áϽµ£¬ÇÒ¿ÉÒÔ»ùÓÚȺÌåÒÅ´«Ñ§Ä£×Ó¹ÀËãmcr-1Ê¢ÐÐÂÊϽµµÄËÙÂÊ¡£¡£Í¬Ê±£¬¸ÃÑо¿»¹Õ¹ÏÖµ±ÄÍÒ©»ùÒò¾ßÓнϸßÇÒÎÞ·¨±»¼òÆÓÍ»±äÏû³ýµÄ˳ӦÐÔ¼ÛǮʱ£¬¿ÉÒÔͨ¹ýÏÞÖÆÏìÓ¦¿¹ÉúËØµÄʹÓÃÀ´¿ØÖÆÉõÖÁÄæ×ªÄÍÒ©ÐÔ£¨ÈçÏÂͼ£©¡£¡£¸ÃÂÛÎÄÑо¿Ð§¹ûΪ×èÖ¹ÄÍÒ©ÐÔµÄÈö²¥¼°Ïà¹ØÕþ²ßµÄÖÆ¶©ÌṩÁËÐÂ˼Ð÷¡£¡£

ngµç×ÓÓÎÏ·ÑÈÙ½ÌÊÚ¡¢¡¢¡¢Ìï¹ú±¦½ÌÊںͳÂÐ¡Êæ½ÌÊÚΪÅäºÏͨѶ×÷Õߣ¬ÍŶӳÉÔ±¹ùè÷åûͬÑâ¡¢¡¢¡¢·ë˼Դ¸±½ÌÊÚ¡¢¡¢¡¢ÁºÂ¶½à²©Ê¿ºÍÎâ׿ÐÒ²©Ê¿ÎªÎÄÕµIJ¢ÁеÚÒ»×÷Õß¡£¡£
ÂÛÎÄÁ´½Ó£º£º£ºhttps://doi.org/10.1016/S2666-5247(24)00052-1