ngµç×ÓÓÎÏ·

03
Ê×Ò³ / ½Ìѧ¿ÆÑÐ / ÕýÎÄ

¹«¹²ÎÀÉúѧԺ£¨ÉîÛÚ£©Áõ˹Ñó¿ÎÌâ×éÕ¹ÏÖÈÑÉïÆÚѪС°å¼ÆÊý¼°ÑªÐ¡°åïÔÌ­Ö¢µÄÒªº¦ÒÅ´«»ùÒò

¸å¼þȪԴ£º£º£º¹«¹²ÎÀÉúѧԺ£¨ÉîÛÚ£© ±à¼­£º£º£ºÂ¬ì½Î¬ ÉóºË£º£º£ºËïÒ«±ó ÔĶÁÁ¿£º£º£º

ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶£¨Í¨Ñ¶Ô±Áõ˹Ñó£©ÈÑÉïÆÚÊÇÈËÀà·±ÑܵÄÒªº¦Ê±ÆÚ¡£¡£¸¾Å®ÔÚÔÐÆÚ»á±¬·¢Ò»ÏµÁÐÐÄÀíת±äÒÔÖ§³ÖÌ¥¶ùµÄÉú³¤ºÍ·¢Óý¡£¡£ÆäÖУ¬ £¬Ôи¾µÄѪС°å¼ÆÊý»áÖð½¥Ï½µ£¬ £¬ÁÙÅèʱµÖ´ï×îµÍÖµ£¬ £¬²úºóÖð½¥»Ö¸´ÖÁÔÐǰˮƽ¡£¡£ÈÑÉïÆÚѪС°åïÔÌ­Ö¢£¨GT£©ÊÇÈÑÉïÆÚ³£¼ûµÄÒ»ÖÖѪҺϵͳ¼²²¡, ÌåÏÖΪѪС°å¼ÆÊýСÓÚ150¡Á109/L¡£¡£È«ÇòÿÄêÓÐÁè¼Ý900ÍòµÄGT»¼Õß¡£¡£GT»¼Õß²úºó´ó³öѪµÄ·çÏÕ»®·ÖÊÇÕý³£Ôи¾µÄ2-3.7±¶¡£¡£ÑªÐ¡°å¼ÆÊýÊÇÒ»¸ö¸ß¶È¿ÉÒÅ´«µÄ±íÐÍ£¬ £¬ÔÚ²î±ðÈËȺÖÐÔ¤¼ÆÆäÒÅ´«Á¦Îª0.45-0.54¡£¡£ÁÙ´²ÉÏÊӲ쵽GT»¼ÕßÔÙ´ÎÈÑÉïʱ¸´·¢µÄ·çÏÕ±ÈÊÇÕý³£Ôи¾µÄ14.2±¶¡£¡£ÕâÌáÐÑÁËÒÅ´«ÒòËØÔÚÈÑÉïÆÚ¶ÔѪС°å¼ÆÊýµÄת±äºÍGTµÄ·¢²¡¿ÉÄܾßÓÐÖ÷Òª×÷Óᣡ£È»¶ø£¬ £¬ÓÉÓÚ×ã¹»¹¦Ð§µÄÒÅ´«Ñ§Ñо¿Éè¼ÆÈÔ±£´æ×ʽ𡢡¢¡¢ÎïÁ÷ºÍÒªÁìµÈ·½ÃæµÄÌôÕ½£¬ £¬Æù½ñΪֹÉÐÎÞÑо¿¶ÔÈÑÉïÆÚѪС°å¼ÆÊýºÍGTµÄÒÅ´«»ù´¡¾ÙÐÐÉîÈë̽ÌÖ¡£¡£

2024Äê4ÔÂ11ÈÕ£¬ £¬ngµç×ÓÓÎÏ·¹«¹²ÎÀÉúѧԺ£¨ÉîÛÚ£©Áõ˹Ñ󸱽ÌÊÚÍŶÓÁªºÏÉîÛÚÊÐÁú¸ÚÇø¸¾Ó×±£½¡ÔºÓëÉîÛÚÊб¦°²Çø¸¾Ó×±£½¡Ôº£¬ £¬ÔÚBloodÆÚ¿¯ÉϽÒÏþÁËÌâΪ¡°Genetic basis of pregnancy-associated decreased platelet counts and gestational thrombocytopenia¡±µÄÑо¿ÂÛÎÄ£¬ £¬Ê×´ÎÕ¹ÏÖÁËÈÑÉïÆÚѪС°å¼ÆÊýµÄת±äºÍGTµÄÒÅ´«»ù´¡¡£¡£

11995C53B15D45DFC29FA786F70_148B741F_211F2

Ñо¿Éè¼ÆºÍÖ÷ҪЧ¹û¸ÅÊö

¸ÃÑо¿»ùÓÚÍŶÓǰÆÚÕë¶Ô³¬µÍÉî¶È·ÇÇÖÈëÐÔ²úǰ¼ì²â£¨NIPT£©²âÐòÊý¾Ý¿ª·¢µÄÒÅ´«Ñ§ÆÊÎöÒªÁ죬 £¬¶Ô100186ÃûÖйúÔи¾¿ªÕ¹ÁËÕë¶ÔÈÑÉïÏà¹ØµÄÎå¸öʱÆÚ£¨ÔÐÔçÆÚ¡¢¡¢¡¢ÔÐÖÐÆÚ¡¢¡¢¡¢ÔÐÍíÆÚ£¬ £¬ÁÙÅèºÍ²úºóÆÚ£©µÄѪС°å¼ÆÊý¡¢¡¢¡¢GT£¨ÑªÐ¡°å¼ÆÊý<150¡Á109/L£©ºÍÖØ¶ÈGT£¨ÑªÐ¡°å¼ÆÊý<100¡Á109/L£©µÈÐÔ×´µÄÒÅ´«Ñ§Ñо¿¡£¡£Í¨¹ýÈ«»ùÒò×鹨ÁªÆÊÎö£¨GWAS£©ÒªÁ죬 £¬Õ¹ÏÖÁËPEAR1ºÍCBL»ùÒò×ùÔÚÔÐÔç¡¢¡¢¡¢ÖС¢¡¢¡¢ÍíÆÚ¶ÔѪС°å¼ÆÊý¾ßÓÐʱ¼äÌØÒìµÄÒÅ´«Ð§Ó¦£¬ £¬²¢ÇÒÔÚPEAR1ºÍTUBB1Á½¸ö»ùÒò×ùÖз¢Ã÷ÁËÓëGTºÍÖØ¶ÈGT±£´æÇ¿ÏÔÖø¹ØÁªµÄµÈλ»ùÒòÐźÅ¡£¡£

ÍŶӾݴËÌá³öÁ˶ÔGT·¢²¡»úÖÆµÄ¼ÙÉ裺£º£ºÐ¯´øPEAR1ºÍTUBB1»ùÒò×ùÌØ¶¨»ùÒòÍ»±äµÄÔи¾ÔÚÔÐǰѪС°å¼ÆÊýƽ¾ùÆ«µÍ¡£¡£Ð¯´øÌض¨PEAR1»ùÒòÍ»±äµÄÔи¾ÈÑÉïÆÚѪС°å¼ÆÊýϽµËÙÂʸü¿ì£¬ £¬×îÖÕÔöÌíÁËGTµÄ·çÏÕ¡£¡£ÕâЩ·¢Ã÷Ϊ½øÒ»²½Ñо¿GTµÈÈÑÉïÏà¹ØÑªÐ¡°å¼ÆÊýÒì³£µÄ¼²²¡ÌṩÁËп´·¨£¬ £¬Ò²ÎªÊ¹ÓÃÃϵ¶ûËæ»ú»¯µÈÒªÁìÉîÈë̽ÌÖGT¶Ô³öÉúϳ¡µÄÒò¹ûÓ°ÏìºÍÉúÎï»úÖÆµÓÚ¨ÁË»ù´¡¡£¡£»£»ùÓÚÉÏÊöGWASÆÊÎö¹¹½¨¶à»ùÒò·çÏÕÆÀ·Ö£¨PRS£©ÓÃÓÚÔ¤²âGT·¢²¡£¬ £¬ÓÐÍû¶ÔGT¾ÙÐÐÔÐǰ·çÏÕÆÀ¹À£¬ £¬Ìá¸ß¸¾Å®ÈÑÉïÆÚ¿µ½¡Ë®Æ½¡£¡£

ngµç×ÓÓÎÏ·¹«¹²ÎÀÉúѧԺ£¨ÉîÛÚ£©Áõ˹Ñ󸱽ÌÊÚÓëÉîÛÚÊÐÁú¸ÚÇø¸¾Ó×±£½¡ÔºÎº·ïÏ㲩ʿ¡¢¡¢¡¢ÉîÛÚÊб¦°²Çø¸¾Ó×±£½¡ÔºÐÜÀñ¿í²©Ê¿Îª±¾ÂÛÎÄÅäºÏͨѶ×÷Õߣ¬ £¬ngµç×ÓÓÎÏ·¹«¹²ÎÀÉúѧԺ£¨ÉîÛÚ£©Ë¶Ê¿Ñо¿ÉúÑî×Óæº¡¢¡¢¡¢ÉîÛÚÊÐÁú¸ÚÇø¸¾Ó×±£½¡ÔººúÁÁ¸±Ö÷ÈÎÖ÷¹Ü¼¼Ê¦ºÍÉîÛÚÊб¦°²Çø¸¾Ó×±£½¡ÔºÕ罨ÐÂÖ÷¹Ü¼¼Ê¦ÎªÂÛÎÄÅäºÏµÚÒ»×÷Õß¡£¡£¸ÃÑо¿»ñµÃÁ˹ú¼Ò×ÔÈ»¿ÆÑ§»ù½ð¡¢¡¢¡¢¹ã¶«Ê¡ÓëÉîÛÚÊлù´¡Ñо¿»ù½ðµÄ×ÊÖú¡£¡£

ÂÛÎÄÁ´½Ó£º£º£ºhttps://doi.org/10.1182/blood.2023021925

¡¾ÍøÕ¾µØÍ¼¡¿